在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human V-set and transmembrane domain-containing protein 1 (VSTM1)

  • 中文名稱:
    人VSTM1重組蛋白
  • 貨號:
    CSB-CF747633HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    VSTM1; UNQ3033/PRO9835; V-set and transmembrane domain-containing protein 1; Signal inhibitory receptor on leukocytes-1; SIRL-1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    17-236
  • 氨基酸序列
    YEDEKKNEKPPKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVLRKVNDSGYKQEQSSAE NEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQLVVTDKHDELEAPSMKTDTRTI FVAIFSCISILLLFLSVFIIYRCSQHSSSSEESTKRTSHSKLPEQEAAEADLSNMERVSL STADPQGVTYAELSTSALSEAASDTTQEPPGSHEYAALKV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).; Inhibitory immune receptor involved in the regulation of phagocytes.
  • 基因功能參考文獻:
    1. VSTM1 rs612529T is associated with a complete demethylation of the VSTM1 promoter and allele-specific upregulation of SIRL-1 expression in monocytes. PMID: 28219444
    2. findings show that SIRL-1 attenuates neutrophil extracellular traps (NET) release by neutrophils in response to distinct triggers, including opsonized Staphylococcus aureus and inflammatory danger signals; define SIRL-1 as an intervention point of benefit to suppress neutrophil extracellular trap formation in disease while preserving intracellular antimicrobial defense PMID: 27016607
    3. VSTM1-v2 might be a biomarker of rheumatoid arthritis (RA) and a novel factor in the pathogenesis of RA. PMID: 26760041
    4. we report a potential leukocyte differentiation antigen gene VSTM1 (V-set and transmembrane domain-containing 1) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation PMID: 25887911
    5. Signaling via the inhibitory receptor SIRL-1 was induced by ligation with anti-SIRL-1 specific antibodies. PMID: 24205237
    6. SIRL-1 negatively regulates the oxidative burst in human phagocytes. PMID: 23436183
    7. Signal inhibitory receptor on leukocytes-1 is a member of immunoglobulin superfamily ITIM; expressed by myeloid but not lymphoid cells; requires both of its ITIMs for full inhibition of Fc epsilon receptor type I-mediated mast cell degranulation. PMID: 20375307

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 2]: Secreted.
  • 組織特異性:
    Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells.
  • 數據庫鏈接:

    HGNC: 29455

    KEGG: hsa:284415

    UniGene: Hs.444431



主站蜘蛛池模板: 狠狠做久久深爱婷婷| 香蕉免费一区二区三区| 日韩一卡二卡三卡四卡免费观在线| 国产亚洲精品电影网站在线观看 | 任你躁x7x7x7x7在线观看| 国产午夜福利100集发布| 制服 丝袜 亚洲 中文 综合 | 色婷婷亚洲一区二区综合| 后入内射国产一区二区| 高h猛烈失禁潮喷无码视频| 亚洲暴爽av人人爽日日碰| 6080亚洲人久久精品| 亚洲色欧美色2019在线| 国产精品自在线拍国产| 无码熟妇人妻av在线影片免费| 日本中文一区二区三区亚洲| 18禁美女裸体免费网站| 日韩插啊免费视频在线观看| 午夜131美女爱做视频| 茄子视频国产在线观看| 中文字幕日韩精品一区二区三区| 午夜精品电影你懂的| 久久被窝亚洲精品爽爽爽| 色噜噜一区二区三区| 日本老熟妇乱| 99精品国产丝袜在线拍国语| 精品久久久中文字幕人妻| 中文字幕在线日亚州9| 亚洲国产精品国自产拍电影| 亚洲国产成人久久综合碰碰| 国产日产人妻精品精品| 精品一区二区三区无码免费视频| 亚洲a∨精品永久无码| 麻豆国产av超爽剧情系列| 中文字幕一区二区人妻| 色噜噜亚洲男人的天堂| 国产第一页浮力影院草草| 无码成人一区二区三区| 久久综合伊人九色综合| 午夜dy888国产精品影院| 情侣作爱视频网站|