在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human V-set and transmembrane domain-containing protein 1 (VSTM1)

  • 中文名稱:
    人VSTM1重組蛋白
  • 貨號:
    CSB-CF747633HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    VSTM1; UNQ3033/PRO9835; V-set and transmembrane domain-containing protein 1; Signal inhibitory receptor on leukocytes-1; SIRL-1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    17-236
  • 氨基酸序列
    YEDEKKNEKPPKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVLRKVNDSGYKQEQSSAE NEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQLVVTDKHDELEAPSMKTDTRTI FVAIFSCISILLLFLSVFIIYRCSQHSSSSEESTKRTSHSKLPEQEAAEADLSNMERVSL STADPQGVTYAELSTSALSEAASDTTQEPPGSHEYAALKV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).; Inhibitory immune receptor involved in the regulation of phagocytes.
  • 基因功能參考文獻:
    1. VSTM1 rs612529T is associated with a complete demethylation of the VSTM1 promoter and allele-specific upregulation of SIRL-1 expression in monocytes. PMID: 28219444
    2. findings show that SIRL-1 attenuates neutrophil extracellular traps (NET) release by neutrophils in response to distinct triggers, including opsonized Staphylococcus aureus and inflammatory danger signals; define SIRL-1 as an intervention point of benefit to suppress neutrophil extracellular trap formation in disease while preserving intracellular antimicrobial defense PMID: 27016607
    3. VSTM1-v2 might be a biomarker of rheumatoid arthritis (RA) and a novel factor in the pathogenesis of RA. PMID: 26760041
    4. we report a potential leukocyte differentiation antigen gene VSTM1 (V-set and transmembrane domain-containing 1) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation PMID: 25887911
    5. Signaling via the inhibitory receptor SIRL-1 was induced by ligation with anti-SIRL-1 specific antibodies. PMID: 24205237
    6. SIRL-1 negatively regulates the oxidative burst in human phagocytes. PMID: 23436183
    7. Signal inhibitory receptor on leukocytes-1 is a member of immunoglobulin superfamily ITIM; expressed by myeloid but not lymphoid cells; requires both of its ITIMs for full inhibition of Fc epsilon receptor type I-mediated mast cell degranulation. PMID: 20375307

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 2]: Secreted.
  • 組織特異性:
    Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells.
  • 數據庫鏈接:

    HGNC: 29455

    KEGG: hsa:284415

    UniGene: Hs.444431



主站蜘蛛池模板: 激情综合色综合啪啪五月丁香搜索| 婷婷丁香社区| 无码少妇a片一区二区三区| 免费精品国偷自产在线在线| 欧美亚洲色欲色一欲www| 久久久中日ab精品综合| 久久精品国产丝袜人妻| 日本亲近相奷中文字幕| 忘忧草日本在线播放www| 蜜桃少妇av久久久久久久| 天天av天天翘天天综合网| 巨胸美乳无码人妻视频| 一区二区精品视频日本| 婷婷伊人久久大香线蕉av| 99国精品午夜福利视频不卡| 欧美熟妇另类久久久久久不卡| 国产三区在线成人av| 日本一区二区三区免费播放视频站| 亚洲欧美不卡视频在线播放| 日韩 欧美 动漫 国产 制服| 久久婷婷五月综合97色直播 | 无遮挡国产高潮视频免费观看 | 欧美欧洲成本大片免费| 在线视频网站www色| 成人伊人亚洲人综合网站| 亚洲色偷偷偷网站色偷一区 | 一本久久知道综合久久| 波多野结衣一区二区三区高清av| 一本大道久久东京热av| 人妻无码系列一区二区三区 | 豆国产95在线 | 亚洲| 久久久亚洲精华液精华液精华液 | 成人午夜高潮a∨猛片| 97久章草在线视频播放| 亚洲丰满熟妇在线播放电影全集| 少妇人妻邻居| 亚洲gv天堂gv无码男同| 精品无码成人片一区二区| 无码h黄肉3d动漫在线观看| 国产精品18久久久| 色欲天天天无码视频|