在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Thyrotropin-releasing hormone receptor (TRHR)

  • 中文名稱:
    人TRHR重組蛋白
  • 貨號:
    CSB-CF024441HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    TRHR; Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-398
  • 氨基酸序列
    MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
  • 基因功能參考文獻:
    1. These results demonstrate for the first time that not only agonist binding but also abundance of some signaling proteins may strongly affect TRH receptor dynamics in the plasma membrane PMID: 29137494
    2. a unique missense TRHR defect identified in a consanguineous family is associated with central hypothyroidism in homozygotes and hyperthyrotropinemia in heterozygotes, suggesting compensatory elevation of TSH with reduced biopotency; the I131T mutation decreases TRH binding and TRHR-Gq coupling and signaling PMID: 28419241
    3. rs16892496 polymorphism in the TRHR gene may play a role in FFM variation. PMID: 23543262
    4. The precoupling of receptors with their cognate G-proteins can contribute to faster G-protein activation and subsequent signal transfer into the cell interior. PMID: 22240728
    5. Data show that interactions of TRHR with GRKs and phosphatases are determined not simply by the amino acid sequences of the substrates, but by regions outside the cytoplasmic tails. PMID: 20345371
    6. A mutation in thyrotropin-releasing hormone receptor almost completely prevented receptor phosphorylation. PMID: 19906838
    7. TRH receptor in adenoma cells plays an important role in the paradoxical GH response to TRH administration in GH cell adenomas. PMID: 14599121
    8. after agonist-driven receptor internalization, the plasma membrane is replenished with younger receptors, arising either from an intracellular pool or preferential recycling of younger receptors. PMID: 15117874
    9. Controlled dimerization of the TRH receptor potentiates hormone-induced receptor trafficking. PMID: 16020481
    10. TRHR gene is an important gene for LBM variation. PMID: 19268274
    11. analysis of the effect of subcellular trafficking of the TRH receptor PMID: 19541745

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:

    HGNC: 12299

    OMIM: 188545

    KEGG: hsa:7201

    STRING: 9606.ENSP00000309818

    UniGene: Hs.3022



主站蜘蛛池模板: 亚洲精品入口一区二区乱麻豆精品| 久久先锋男人av资源网站| 日韩欧无码一二三区免费不卡| a级大胆欧美人体大胆666| 国产在线一区二区香蕉 在线| 狠狠的干性视频| 正在播放重口老熟女露脸| 亚洲欧洲日本无在线码| 国语高潮无遮挡无码免费看| 日本一区不卡高清更新二区| 国产av一区二区三区| 国产精品国产三级国产aⅴ下载 | 国产制服丝袜亚洲高清| 国产啪视频1000部免费| 中文字幕亚韩| 久久aⅴ无码av高潮av喷吹| 亚洲午夜成人精品无码app| √天堂中文最新版在线中文| 国产成a人亚洲精品无码久久网 | 国产天美传媒性色av出轨| 成人国产一区二区精品小说| 里番本子纯肉侵犯肉全彩无码| 无码人妻精品一区二| 99视频国产精品免费观看| 嫩草伊人久久精品少妇av| 国产熟妇高潮叫床视频播放| 国产高清不卡无码视频| 顶级欧美熟妇高潮xxxxx| 亚洲精品一区久久久久一品av| 成人h动漫精品一区二区| 国产麻豆精品精东影业av网站 | 国产熟妇久久777777| 中文人妻av久久人妻18| 国产成人亚洲综合色婷婷秒播| 激情欧美成人久久综合| 亚洲久悠悠色悠在线播放| 日日摸日日碰夜夜爽免费| 精品国产福利拍拍拍| 一区二区乱子伦在线播放| 少妇与子乱在线观看| 正在播放国产真实露脸高清|