在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Thyrotropin-releasing hormone receptor (TRHR)

  • 中文名稱:
    人TRHR重組蛋白
  • 貨號:
    CSB-CF024441HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    TRHR; Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-398
  • 氨基酸序列
    MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
  • 基因功能參考文獻:
    1. These results demonstrate for the first time that not only agonist binding but also abundance of some signaling proteins may strongly affect TRH receptor dynamics in the plasma membrane PMID: 29137494
    2. a unique missense TRHR defect identified in a consanguineous family is associated with central hypothyroidism in homozygotes and hyperthyrotropinemia in heterozygotes, suggesting compensatory elevation of TSH with reduced biopotency; the I131T mutation decreases TRH binding and TRHR-Gq coupling and signaling PMID: 28419241
    3. rs16892496 polymorphism in the TRHR gene may play a role in FFM variation. PMID: 23543262
    4. The precoupling of receptors with their cognate G-proteins can contribute to faster G-protein activation and subsequent signal transfer into the cell interior. PMID: 22240728
    5. Data show that interactions of TRHR with GRKs and phosphatases are determined not simply by the amino acid sequences of the substrates, but by regions outside the cytoplasmic tails. PMID: 20345371
    6. A mutation in thyrotropin-releasing hormone receptor almost completely prevented receptor phosphorylation. PMID: 19906838
    7. TRH receptor in adenoma cells plays an important role in the paradoxical GH response to TRH administration in GH cell adenomas. PMID: 14599121
    8. after agonist-driven receptor internalization, the plasma membrane is replenished with younger receptors, arising either from an intracellular pool or preferential recycling of younger receptors. PMID: 15117874
    9. Controlled dimerization of the TRH receptor potentiates hormone-induced receptor trafficking. PMID: 16020481
    10. TRHR gene is an important gene for LBM variation. PMID: 19268274
    11. analysis of the effect of subcellular trafficking of the TRH receptor PMID: 19541745

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:

    HGNC: 12299

    OMIM: 188545

    KEGG: hsa:7201

    STRING: 9606.ENSP00000309818

    UniGene: Hs.3022



主站蜘蛛池模板: 农村欧美丰满熟妇xxxx| 国产男女性潮高清免费网站| 日本免费一区二区三区最新| 国产一区二区精品久久| 大肉大捧一进一出视频出来呀| 久久www免费人成_看片| 挺进邻居丰满少妇的身体| 国产成人欧美日韩在线电影| 免费国产线观看免费观看| 免费观看又污又黄的网站| 免费久久人人爽人人爽av| 精品www日韩熟女人妻| 丰满爆乳在线播放| 日韩精品无码人成视频| 精品动漫一区二区无遮挡| 久久这里精品国产99丫e6| 老太婆性杂交视频| 亚洲爆乳无码专区www| 亚洲精品无码高潮喷水a片软| av无码av在线a∨天堂毛片| 精品无码国产自产拍在线观看| 狠狠色噜噜狠狠狠7777奇米| 精品久久久久久久免费人妻| 国产爆乳无码视频在线观看 | 亚洲日本va中文字幕| 国产亚洲视频在线播放香蕉| 成人无码专区免费播放三区| 性欧美丰满熟妇xxxx性| 黄页网址大全免费观看| www插插插无码视频网站| 激情综合色五月六月婷婷| 亚洲sm另类一区二区三区| 人体内射精一区二区三区| 97久久国产亚洲精品超碰热| 少妇高潮太爽了在线观看| 久久久av男人的天堂| 少妇无码av无码专区线y| 无码熟妇人妻av在线电影| 成人av片无码免费网站| 日韩加勒比一本无码精品| 麻豆精品传媒一二三区艾秋|