在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Sarcospan (SSPN)

  • 中文名稱:
    人SSPN重組蛋白
  • 貨號:
    CSB-CF622786HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    SSPN
  • Uniprot No.:
  • 別名:
    SSPN; KRAG; Sarcospan; K-ras oncogene-associated protein; Kirsten-ras-associated protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-243
  • 氨基酸序列
    MGKNKQPRGQQRQGGPPAADAAGPDDMEPKKGTGAPKECGEEEPRTCCGCRFPLLLALLQ LALGIAVTVVGFLMASISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFS MKLLYFLLSALGLTVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRD VTDCTSVTGTFKLFLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQ QKI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.
  • 基因功能參考文獻:
    1. Our data suggest TWIST1 and SSPN to be the functionally relevant androgenetic alopecia genes at the 7p21.1 and 12p12.1 risk loci, respectively. PMID: 27060448
    2. When human SSPN is expressed at three-fold levels in mdx mice, this increase in adhesion complex abundance improves muscle membrane stability, preventing many of the histopathological changes associated with Duchenne muscular dystrophy PMID: 27798107
    3. Analysis of sarcospan as a candidate gene for congenital fibrosis of the extraocular muscles type 1. PMID: 11180757
    4. Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene. PMID: 11956653
    5. Sarcospan plays an important mechanical role in stabilizing the dystrophin-glycoprotein complex. PMID: 17311848
    6. crystal structure of Imp beta (127-876) in complex SPN1 (1-65) at 2.8-A resolution reveals that Imp beta adopts an open conformation, which is unique for a functional Imp beta/cargo complex, and resembles the conformation of the Imp beta/RanGTP complex PMID: 18028944
    7. decreased expression of sarcospan at the Fukuyama congenital muscular dystrophy myofiber surfaces. PMID: 18830929
    8. Human SSPN in transgegnic mice directly interacts with utrophin-glycoprotein comlpex and functions to stabilize utrophin protein without increasing utrophin transcription. PMID: 18981229

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 組織特異性:
    Isoform 1 is expressed exclusively in heart and skeletal muscle. Isoform 2 is expressed in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon and spleen.
  • 數據庫鏈接:

    HGNC: 11322

    OMIM: 601599

    KEGG: hsa:8082

    STRING: 9606.ENSP00000242729

    UniGene: Hs.183428



主站蜘蛛池模板: 超碰曰口干天天种夜夜爽| 男人j桶进女人p无遮挡免费观看| 欧美丰满熟妇xx猛交| 久久激情五月丁香伊人 | 亚洲国产成人精品无码区99| 夜夜爽一区二区三区精品| 国产精品进线69影院| 久久精品亚洲乱码伦伦中文| 亚洲欧美中文日韩v在线97| 后入到高潮免费观看| 少妇挑战三个黑人惨叫4p国语| 免费精品国偷自产在线在线| 夜夜澡天天碰人人爱av| 免费做爰猛烈吃奶摸视频在线观看| 久久精品国产精品亚洲色婷婷 | 天天拍夜夜添久久精品| 一本清日本在线视频精品| 久久久久亚洲精品中文字幕| 精品国产sm最大网免费站| 日本成本人片视频免费| 天天爽天天狠久久久综合麻豆| 亚洲欧洲日韩综合久久| 免费久久人人爽人人爽av| 成人国产mv免费视频| 日韩av高潮喷水在线观看| 免费拍拍拍网站| 中文字幕aⅴ人妻一区二区| 女乱高潮久久久久久爽爽| 九九久久精品国产波多野结衣| 99精品久久精品一区二区| 国产免费丝袜调教视频| 国产日产欧产精品精品ai| 大狠狠大臿蕉香蕉大视频| 无码办公室丝袜ol中文字幕| 亚洲一区av无码少妇电影| 亚洲一码二码三码精华液| 亚洲国产天堂久久综合网| 久久av高清无码| 成人伊人亚洲人综合网站| 狠狠噜狠狠狠狠丁香五月| 亚洲国产av精品一区二区蜜芽 |