在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Proteinase-activated receptor 3 (F2RL2)-VLPs

  • 中文名稱:
    Recombinant Human Proteinase-activated receptor 3 (F2RL2)-VLPs
  • 貨號:
    CSB-MP007926HU
  • 規(guī)格:
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    (PAR-3)(Coagulation factor II receptor-like 2)(Thrombin receptor-like 2)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Mammalian cell
  • 表達區(qū)域:
    39-374aa
  • 氨基酸序列
    TFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
  • 基因功能參考文獻:
    1. PAR3 is essential in thrombin stimulated insulin secretion. PMID: 26742564
    2. TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS-Thr-495 with minimal phosphorylation of eNOS-Ser-1177 with no change in nitric oxide production. PMID: 26729042
    3. These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR activation, such as the activation of vascular-protective Tie2 by noncanonical PAR3 activation. PMID: 25320242
    4. In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin, leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav. PMID: 24699825
    5. Elevated expression of PAR-3, but not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients. PMID: 23739922
    6. A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C cytoprotective effects. PMID: 23788139
    7. PAR-3 receptors interact with thrombin and increase heme oxygenase-1 expression in synovial fibroblasts. PMID: 22541814
    8. Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR, whereas transcriptional control involves nuclear factor of activated T cells (NFAT). PMID: 21596928
    9. FXa bound in a punctate manner to thrombi under shear, while thrombin and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi PMID: 20454680
    10. genetic polymorphism is associated with peripheral arterial disease severity PMID: 20390230
    11. A novel role is identified for PAR3 in thrombin signaling. PMID: 20442298
    12. Down-regulation of connexin and par-3 signals early anaplasia and malignant change in rectal cancer. PMID: 19513616
    13. upregulated thrombin generation and inhibition of fibrinolysis, occurred in one-third of the Stem cell transplant patients associating with the development of Graft versus host disease PMID: 19718071
    14. Lower plasma levels of thrombin-antithrombin complex correlate to higher recanalisation rates after ischaemic stroke PMID: 19806263
    15. PAR-3 is expressed in human SMC and triggers intracellular calcium signaling. PMID: 14515192
    16. expression of PAR3 mRNA and protein in cells undergoing megakaryocytic maturation suggests a developmental role for PAR3; regulation of PAR3 expression appears to be specifically coupled to the protein kinase C system. PMID: 15504554
    17. a Na-independent Cl-/HCO3- exchange mechanism mediates the recovery of pHi from alkalosis in platelets and that thrombin activates this exchanger by a direct regulatory pathway PMID: 15850610
    18. The changes in levels of blood coagulation factor ii in folic acid deficient rats are reversed by treatment with folic acid. PMID: 16046705
    19. F2R genetic variants may influence the natural history of CHD in patients at high risk of cardiovascular events. PMID: 17347481
    20. PAR-3 is able to signal autonomously to induce IL-8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses PMID: 18264801
    21. Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. PMID: 18836030
    22. This study demonstrates that the anticoagulant profile of thrombin often caused by a mutation of the thrombin scaffold finds its likely molecular origin in the stabilization of the inactive E* form. PMID: 19473969
    23. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. PMID: 19586901

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.
  • 數(shù)據庫鏈接:

    HGNC: 3539

    OMIM: 601919

    KEGG: hsa:2151

    STRING: 9606.ENSP00000296641

    UniGene: Hs.42502



主站蜘蛛池模板: 18精品久久久无码午夜福利| 好爽又高潮了毛片免费下载| 国产午夜亚洲精品午夜鲁丝片| 精品女同一区二区三区免费站| 少妇白浆呻吟爽| 97色伦午夜国产亚洲精品| 999久久久免费精品国产| 亚洲精品国产一区二区| 99re热这里只有精品视频| 久久精品国产99久久丝袜蜜桃| 中文成人无码精品久久久动漫| 护士被强女千到高潮视频| 久久亚洲中文字幕无码| 色天天天综合色天天| 日韩av无码一区二区三区无码 | 国产色在线 | 国产| 久久天天躁狠狠躁夜夜2020老熟妇 | 色99久久久久高潮综合影院| 九九热爱视频精品视频| 玩弄少妇高潮ⅹxxxyw| 精品无码中文字幕在线| 午夜免费啪视频在线观看区 | 久久久亚洲精品av无码| 99久久99久久久精品齐齐| 成人午夜高潮a∨猛片| 孕妇怀孕高潮潮喷视频孕妇 | 一本一本久久a久久综合精品| 中文字幕资源网| 亚洲熟妇av日韩熟妇在线| 亚洲伊人久久综合成人| 婷婷成人五月综合激情| 天天摸日日摸狠狠添| 国产成人精品.视频| 国语自产视频在线| 无码人妻丝袜在线视频| 亚洲国产精品一区第二页| 国产精品白丝久久av网站| 亚洲精品网站在线观看你懂的| 欧美日韩在线视频| 天天爱天天做天天爽夜夜揉| 亚洲欧美日韩成人一区在线|