在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP)

  • 中文名稱:
    人PTTG1IP重組蛋白
  • 貨號:
    CSB-CF019075HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    PTTG1IP
  • Uniprot No.:
  • 別名:
    PTTG1IP; C21orf1; C21orf3; Pituitary tumor-transforming gene 1 protein-interacting protein; Pituitary tumor-transforming gene protein-binding factor; PBF; PTTG-binding factor
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    33-180
  • 氨基酸序列
    QEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    May facilitate PTTG1 nuclear translocation.
  • 基因功能參考文獻:
    1. Nnegative pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) immunoexpression predicted a 1.5-fold risk of breast cancer death. PMID: 29078751
    2. data reveal new insight into PBF function and confirm that, rather than being oncogenic, mutations in PBF are likely to be passenger effects, with overexpression of PBF the more important etiological event in human cancer PMID: 28676500
    3. PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2. PMID: 27709636
    4. Findings indicate that PBF and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome. PMID: 28504713
    5. Unique role for PBF in regulating CTTN function to promote endocrine cell invasion and migration. PMID: 27603901
    6. these results demonstrate an emerging role for PBF in colorectal tumorigenesis through regulating p53 activity, with implications for PBF as a prognostic indicator for invasive tumors. PMID: 25408419
    7. These findings indicate that miR-584 suppresses glioma cell growth by negatively regulating the expression of PTTG1IP, suggesting that miR-584 has a tumor suppressive role in human glioma pathogenesis. PMID: 25674221
    8. protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are rare compared with other tumor types PMID: 24506068
    9. Data from mutant recombinant proteins suggest that proto-oncogene PBF is a phosphoprotein and highlight importance of tyrosine residue Y174 in both endocytosis of PBF and its interaction/co-localization with NIS/SLC5A5 (sodium-iodide symporter). PMID: 23678037
    10. PBF expression may be a promising biomarker for prognostic and therapeutic purposes in papillary thyroid carcinoma patients. PMID: 22888961
    11. Authors identified pituitary tumor-transforming gene 1 (PTTG1) binding factor (PBF) as a target of miR-122 and demonstrated that hepatitis B virus replication causes an obvious increase in PBF levels. PMID: 23221562
    12. The present study provides the first epidemiological evidence that functional regulatory variants of PTTG1IP were associated with the risk of ER-positive breast cancer, further supporting its relevance as one proto-oncogene in breast cancer. PMID: 22404099
    13. overexpression of PBF causes thyroid cell proliferation, macrofollicular lesions, and hyperplasia, as well as repression of the critical therapeutic route for radioiodide uptake PMID: 21844185
    14. PBF's role in endocrine cancer is discussed. [review] PMID: 21129230
    15. PTTG expression was higher in malignant cells than in primary astrocytes, whereas PTTG-binding factor was not in astrocytoma PMID: 15178645
    16. overexpression of PTTG and PBF in differentiated thyroid cancer has profound implications for activity of the NIS gene, and hence significantly impacts upon the efficacy of radioiodine treatment. PMID: 17297475

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 13524

    OMIM: 603784

    KEGG: hsa:754

    STRING: 9606.ENSP00000328325

    UniGene: Hs.474010



主站蜘蛛池模板: 国产精品久久久久久久9999| 亚洲乱亚洲乱妇24p| 国产99久久久国产精品免费看| 少妇被粗大的猛进69视频| 中国精品偷拍区偷拍无码| 乱码午夜-极国产极内射| 五月婷婷激情第四季| 伊人久久大香线蕉综合bd高清| 日本三级在线播放线观看视频| 亚洲国产婷婷综合在线精品| 大胆欧美熟妇xxbbwwbw高潮了| 久久欧美与黑人双交男男| 娇小萝被两个黑人用半米长| 男女车车的车车网站w98免费| 婷婷五月综合丁香在线| 无码精品人妻一区二区三区98| 中文字字幕在线成人av电影| 中文亚洲欧美日韩无线码| 97se亚洲国产综合在线| 中文在线а√在线天堂中文| 久久国产精品日本波多野结衣| 男人边吃奶边做好爽免费视频| 丰满少妇熟乱xxxxx视频| 狼人无码精华av午夜精品| 国产精品乱码一区二区三 | 亚洲αv无码一区二区三区四区| 一本一道久久综合久久| 英语老师丝袜娇喘好爽视频| 亚洲欧洲中文日韩久久av乱码| 久久精品女人天堂av| 色v99在线影院| 亚洲无线码中文字幕在线| 久久久亚洲精品成人| 中文在线最新版天堂| 久久综合精品无码av一区二区三区| 亚洲 欧美 动漫 少妇 自拍| 国产精品美女久久久久av超清| 天天摸夜夜摸夜夜狠狠摸 | 天天综合网天天综合色| 暖暖 在线 日本 免费 中文| 国产成人无码免费视频97|