在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PTTG1IP Antibody

  • 中文名稱:
    PTTG1IP兔多克隆抗體
  • 貨號:
    CSB-PA180177
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from RAW264.7 cells, using PTTG antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using PTTG antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PTTG1IP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PTTG1IP
  • 別名:
    PTTG1IP; C21orf1; C21orf3; Pituitary tumor-transforming gene 1 protein-interacting protein; Pituitary tumor-transforming gene protein-binding factor; PBF; PTTG-binding factor
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide(116-165aa) derived from Human PTTG1IP.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    May facilitate PTTG1 nuclear translocation.
  • 基因功能參考文獻:
    1. Nnegative pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) immunoexpression predicted a 1.5-fold risk of breast cancer death. PMID: 29078751
    2. data reveal new insight into PBF function and confirm that, rather than being oncogenic, mutations in PBF are likely to be passenger effects, with overexpression of PBF the more important etiological event in human cancer PMID: 28676500
    3. PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2. PMID: 27709636
    4. Findings indicate that PBF and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome. PMID: 28504713
    5. Unique role for PBF in regulating CTTN function to promote endocrine cell invasion and migration. PMID: 27603901
    6. these results demonstrate an emerging role for PBF in colorectal tumorigenesis through regulating p53 activity, with implications for PBF as a prognostic indicator for invasive tumors. PMID: 25408419
    7. These findings indicate that miR-584 suppresses glioma cell growth by negatively regulating the expression of PTTG1IP, suggesting that miR-584 has a tumor suppressive role in human glioma pathogenesis. PMID: 25674221
    8. protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are rare compared with other tumor types PMID: 24506068
    9. Data from mutant recombinant proteins suggest that proto-oncogene PBF is a phosphoprotein and highlight importance of tyrosine residue Y174 in both endocytosis of PBF and its interaction/co-localization with NIS/SLC5A5 (sodium-iodide symporter). PMID: 23678037
    10. PBF expression may be a promising biomarker for prognostic and therapeutic purposes in papillary thyroid carcinoma patients. PMID: 22888961
    11. Authors identified pituitary tumor-transforming gene 1 (PTTG1) binding factor (PBF) as a target of miR-122 and demonstrated that hepatitis B virus replication causes an obvious increase in PBF levels. PMID: 23221562
    12. The present study provides the first epidemiological evidence that functional regulatory variants of PTTG1IP were associated with the risk of ER-positive breast cancer, further supporting its relevance as one proto-oncogene in breast cancer. PMID: 22404099
    13. overexpression of PBF causes thyroid cell proliferation, macrofollicular lesions, and hyperplasia, as well as repression of the critical therapeutic route for radioiodide uptake PMID: 21844185
    14. PBF's role in endocrine cancer is discussed. [review] PMID: 21129230
    15. PTTG expression was higher in malignant cells than in primary astrocytes, whereas PTTG-binding factor was not in astrocytoma PMID: 15178645
    16. overexpression of PTTG and PBF in differentiated thyroid cancer has profound implications for activity of the NIS gene, and hence significantly impacts upon the efficacy of radioiodine treatment. PMID: 17297475

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus.
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 13524

    OMIM: 603784

    KEGG: hsa:754

    STRING: 9606.ENSP00000328325

    UniGene: Hs.474010



主站蜘蛛池模板: 色老久久精品偷偷鲁| 国产精品久久无码一区| 国产午国产午夜精华 免费| 男女野外做爰全过程69影院| 人妻少妇伦在线麻豆m电影| 亚洲色无码中文字幕在线| 狂野欧美激情性xxxx| 久久婷婷五月综合色欧美| 孕妇怀孕高潮潮喷视频孕妇| 久久天天躁狠狠躁夜夜躁app| 色妞色综合久久夜夜| 艳妇臀荡乳欲伦交换在线播放| 天天做av天天爱天天爽| 亚洲第一a在线观看网站| 中文亚洲欧美日韩无线码| 伊人色综合久久天天小片| 中日韩精品无码一区二区三区| √天堂中文最新版在线中文| 国产精品久线在线观看| 久久精品国产久精国产一老狼| 成人午夜无码精品免费看| 一区二区在线 | 国| 超碰97久久国产精品牛牛| 国产熟睡乱子伦午夜视频| 肉感饱满中年熟妇日本| 国产亚洲va在线电影| 亚洲一区二区| 国产成人精品日本亚洲77上位| 成人无码视频在线观看大全| 久久精品国产只有精品96| 国产日韩成人内射视频| 少妇做爰免费视看片| 国产偷窥熟精品视频| 久久99国产精品久久99| 久久精品午夜福利| 色一情一区二| 久在线视视频在线观看| 国模冰莲自慰肥美胞极品人体图| 国产伦子沙发午休系列资源曝光| 中国少妇内射xxxhd| 激情欧美成人久久综合|