在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Mitochondrial thiamine pyrophosphate carrier (SLC25A19)-VLPs

  • 中文名稱:
    Recombinant Human Mitochondrial thiamine pyrophosphate carrier (SLC25A19)-VLPs
  • 貨號:
    CSB-MP864025HU
  • 規(guī)格:
  • 其他:

產(chǎn)品詳情

  • 基因名:
    SLC25A19
  • Uniprot No.:
  • 別名:
    (Mitochondrial uncoupling protein 1)(Solute carrier family 25 member 19)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 表達區(qū)域:
    1-320aa
  • 氨基酸序列
    MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCNVFHCMNRTASQR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.
  • 基因功能參考文獻:
    1. Pancreatic acinar cells Mitochondrial Thiamin Pyrophosphate uptake process is adaptively regulated by the prevailing thiamin level and this regulation is exerted at the level of transcription of the SLC25A19 gene and involves transcription factor binding affinity/epigenetic mechanisms. PMID: 28729247
    2. Among 6 residues predicted by the docking model ( Thr(29), Arg(30), Ile(33), Ser(34), Asp(37) and Phe(298)), only Ile(33), Ser(34) and Asp(37) were critical for function. Ser(34) did not affect translation/stability. Ile(33) and Asp(37) mutants decreased this parameter andwere expressed less in mitochondria. A polar residue was needed at position 34. His(137) and Lys(291) are needed for delivery to mitochondria. PMID: 27188525
    3. Chronic alcohol exposure negatively impacts pancreatic mitochondrial thiamin pyrophosphate transport, and this effect is exerted, at least in part, at the level of Slc25a19 transcription and appears to involve an epigenetic mechanism. PMID: 26316591
    4. These findings demonstrate that the genes involved in dictating thiamine homeostasis, such as SLC19A2, SLC25A19 and TPK-1, were significantly up-regulated in clinical tissues and breast cancer cell lines. PMID: 23642734
    5. Characterization of the SLC25A19 promoter and demonstration of an essential role for NF-Y in its basal activity. PMID: 23872534
    6. mutant protein lacks the normal transport activity, implying that failed deoxynucleotide transport across the inner mitochondrial membrane causes Amiah microcephaly (MCPHA) PMID: 12185364
    7. mitochondria of Slc25a19(-/-) and Amish lethal microcephaly cells have undetectable and markedly reduced thiamine pyrophosphate content, respectively PMID: 17035501
    8. We review the evidence that the function of the SLC25A19 gene product, previously identified as the mitochondrial deoxyribonucleotide carrier (DNC), is actually the transport of thiamine pyrophosphate.[review] PMID: 18280798
    9. a pathogenic missense mutation in the SLC25A19 gene was identifiedin 4 patients who suffered from recurrent episodes of flaccid paralysis and encephalopathy associated with bilateral striatal necrosis and chronic progressive polyneuropathy PMID: 19798730

    顯示更多

    收起更多

  • 相關疾病:
    Microcephaly, Amish type (MCPHA); Thiamine metabolism dysfunction syndrome 4, bilateral striatal degeneration and progressive polyneuropathy type (THMD4)
  • 亞細胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性:
    Expressed in all tissues examined except for placenta. Highest levels in colon, kidney, lung, testis, spleen, and brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14409

    OMIM: 606521

    KEGG: hsa:60386

    STRING: 9606.ENSP00000319574

    UniGene: Hs.514470



主站蜘蛛池模板: 最新亚洲中文av在线不卡| 国产成人精品三级麻豆| 乱人伦人妻中文字幕无码| 人人爽人人爽人人爽人人片av| 国产99久一区二区三区a片| 纯肉无遮挡无码日本动漫| 无码人妻丰满熟妇区五十路在线| 国产精品自在线一区| 亚洲精品无码不卡在线播放| 国产猛烈高潮尖叫视频免费| 3d动漫精品啪啪一区二区| 人妻少妇精品专区性色av| 成人麻豆亚洲综合无码精品| 潮喷大喷水系列无码| 亚洲国产精品成人久久蜜臀| 久久久久久久极品内射| 大乳丰满人妻中文字幕日本电影 | 业余 自由 性别 成熟视频 视频| 欧美日韩精品无码一本二本三本色| 国产在线无码播放不卡视频| 色婷婷亚洲一区二区综合| 国产伦精品免编号公布| 日韩精品久久久久久久电影蜜臀| 97久久超碰国产精品最新| 亚洲成av 人片在线观看无码 | 22222se男人的天堂| 精品无码久久久久久国产| 国产亚洲精aa在线观看不卡| 国产精品亚洲a∨天堂| 亚洲国产成人无码av在线| 人妻少妇精品无码专区二区| 女人被狂爆到高潮免费视频| 欧美精欧美乱码一二三四区| 日韩内射美女人妻一区二区三区| 精品免费久久久久久久| 国产白浆喷水在线视频| 丁香狠狠色婷婷久久综合| 99久久精品国产第一页| 国产又黄又爽又猛免费视频播放| 人妻丝袜av先锋影音先| 99久久国产成人免费网站|