在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Melatonin-related receptor (GPR50)

  • 中文名稱:
    人GPR50重組蛋白
  • 貨號:
    CSB-CF622668HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    GPR50; Melatonin-related receptor; G protein-coupled receptor 50; H9
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-617
  • 氨基酸序列
    MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMF VIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNEN FRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEE TPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKP VSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGH HVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELS ASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDY HDVVVIDVEDDPDEMAV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Does not bind melatonin.
  • 基因功能參考文獻:
    1. GPR50 is a TbetaRI co-receptor with potential impact on cancer development PMID: 29572483
    2. Pre-eclampsia (PE) plasma IgG1 anti-Epstein-Barr virus nuclear antigen 1 (EBNA-1) antibody cross-reacts with placental protein G protein-coupled receptor 50 (GPR50). PMID: 27181993
    3. The results provide deeper insight into the functional evolution of GPR50 in mammals at the molecular level PMID: 25730005
    4. There was only weak female-specific association between GPR50 variants in late-life depression. No significant associations were observed in men. PMID: 25798330
    5. study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 in females. PMID: 21565467
    6. Positive expression of melatonin receptor can be found in human hypertrophic scar and normal skin, but it is higher in scar. PMID: 20737950
    7. we found 2 polymorphisms in the GPR50 receptor of patients with adolescent idiopathic scoliosis, but they were not present at a highly significant frequency when compared with controls PMID: 20733416
    8. Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus. PMID: 20210849
    9. This is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus. PMID: 20371266
    10. Results identify neurite outgrowth inhibitor NOGO-A as an interacting partner of GPR50 and found an enrichment of both Gpr50 and neuronal Nogo-A at the synapse. PMID: 19699797
    11. Polymorphisms in GPR50 were compared in bipolar affective disorder (BD), major depressive disorder (MDD), schizophrenia (SCZ) and controls. GPR50(Delta502-505) or a variant is a sex-specific risk factor for susceptibility to BD and SCZ. PMID: 15452587
    12. Results describe sequence variants in the melatonin-related receptor gene (GPR50) that associate with circulating triglyceride and HDL levels. PMID: 16436372
    13. GPR50, an orphan GPCR, heterodimerizes constitutively and specifically with MT(1) and MT(2) melatonin receptors PMID: 16778767
    14. No evidence for an association for this gene with mood disorders in a Hungarian population. PMID: 18075476

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Hypothalamus and pituitary.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4506

    OMIM: 300207

    KEGG: hsa:9248

    STRING: 9606.ENSP00000218316

    UniGene: Hs.567390



主站蜘蛛池模板: 午夜无码国产理论在线| 99精品热这里只有精品| 大陆国产乱人伦| 亚洲欧洲日产国码无码| 法国伦理少妇愉情| 国产成人一区二区三区别| 国产亚洲产品影视在线产品| 在线视频国产网址你懂的| 精品久久久中文字幕人妻| 业余 自由 性别 成熟偷窥| 宅男666在线永久免费观看| 青乐娱精品视频一国产分类| 少妇的丰满人妻hd高清| 国产激情电影综合在线看| 搡老女人老妇女老熟妇| 成人影片麻豆国产影片免费观看 | 国产98在线 | 免费| 国产成人av一区二区三区在线观看| 久久国产欧美日韩精品| 丰满多毛的大隂户毛茸茸| 日本国产成人国产在线播放 | 亚洲一区二区三区国产精品无码 | 亚洲国产福利一区二区三区| 欧美成人精品三级网站| 国产午夜亚洲精品不卡| 国产视频亚洲精品视频| 国内精品伊人久久久久av影院| 99久久久无码国产精品不卡| 国产人妻精品一区二区三区| 久久久欧美精品激情| 97夜夜澡人人双人人人喊| 99久热re在线精品99 6热视频| 日韩精品一区二区三区中文 | 欧美xxxxx精品| 麻豆精产国品| 亚洲理论在线a中文字幕| 精品无码国产日韩制服丝袜| 亚洲国产精品美女久久久久| 夜夜躁狠狠躁2021| a狠狠久久蜜臀婷色中文网| 免费的av网站手机版|