在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Melatonin-related receptor (GPR50)

  • 中文名稱:
    人GPR50重組蛋白
  • 貨號:
    CSB-CF622668HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    GPR50; Melatonin-related receptor; G protein-coupled receptor 50; H9
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-617
  • 氨基酸序列
    MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMF VIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNEN FRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEE TPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKP VSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGH HVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELS ASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDY HDVVVIDVEDDPDEMAV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Does not bind melatonin.
  • 基因功能參考文獻:
    1. GPR50 is a TbetaRI co-receptor with potential impact on cancer development PMID: 29572483
    2. Pre-eclampsia (PE) plasma IgG1 anti-Epstein-Barr virus nuclear antigen 1 (EBNA-1) antibody cross-reacts with placental protein G protein-coupled receptor 50 (GPR50). PMID: 27181993
    3. The results provide deeper insight into the functional evolution of GPR50 in mammals at the molecular level PMID: 25730005
    4. There was only weak female-specific association between GPR50 variants in late-life depression. No significant associations were observed in men. PMID: 25798330
    5. study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 in females. PMID: 21565467
    6. Positive expression of melatonin receptor can be found in human hypertrophic scar and normal skin, but it is higher in scar. PMID: 20737950
    7. we found 2 polymorphisms in the GPR50 receptor of patients with adolescent idiopathic scoliosis, but they were not present at a highly significant frequency when compared with controls PMID: 20733416
    8. Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus. PMID: 20210849
    9. This is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus. PMID: 20371266
    10. Results identify neurite outgrowth inhibitor NOGO-A as an interacting partner of GPR50 and found an enrichment of both Gpr50 and neuronal Nogo-A at the synapse. PMID: 19699797
    11. Polymorphisms in GPR50 were compared in bipolar affective disorder (BD), major depressive disorder (MDD), schizophrenia (SCZ) and controls. GPR50(Delta502-505) or a variant is a sex-specific risk factor for susceptibility to BD and SCZ. PMID: 15452587
    12. Results describe sequence variants in the melatonin-related receptor gene (GPR50) that associate with circulating triglyceride and HDL levels. PMID: 16436372
    13. GPR50, an orphan GPCR, heterodimerizes constitutively and specifically with MT(1) and MT(2) melatonin receptors PMID: 16778767
    14. No evidence for an association for this gene with mood disorders in a Hungarian population. PMID: 18075476

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Hypothalamus and pituitary.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4506

    OMIM: 300207

    KEGG: hsa:9248

    STRING: 9606.ENSP00000218316

    UniGene: Hs.567390



主站蜘蛛池模板: 亚洲高清国产拍精品26u| 正在播放的国产a一片| 国产99青草视频在线播放视| 国产精品玖玖玖在线| 在线看亚洲十八禁网站| 蜜桃视频网站| 四虎亚洲精品无码| 丰满的少妇被猛烈进入白浆| 天天av天天翘天天综合网| 欧美成人家庭影院| 久久久久国色av免费看图片| 亚洲欧美国产va在线播放 | 波多野结衣网站| 翘臀后进少妇大白嫩屁股| 久久久橹橹橹久久久久| 隔壁人妻偷人bd中字| 特级无码毛片免费视频播放▽| 国产孩cao大人xxxx| 99在线精品视频观看免费| 国产精品自产拍在线观看| 久久久精品区二区三区免费| 亚洲国产精品无码专区成人| 大黑人交xxxx18视频| av无码一区二区三区| 中文无码成人免费视频在线观看| 狠狠久久精品中文字幕无码| 午夜无码国产理论在线| 亚洲午夜爱爱香蕉片| 国产亚洲精品ae86| 极品少妇被弄得高潮不断| 青青草视频在线观看| 免费夜色污私人影院在线观看| 十八禁啪啪无遮挡网站| 国产精品无码嫩草地址更新| 精品少妇人妻av无码久久| 动漫精品专区一区二区三区不卡| 无码三级中文字幕在线观看| 凹凸在线无码免费视频| 女人爽到高潮潮喷18禁网站| 五月色婷婷丁香无码三级| 国产亚洲精品精品国产亚洲综合|