在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Matrix metalloproteinase-16 (MMP16)

  • 中文名稱:
    人MMP16重組蛋白
  • 貨號:
    CSB-CF014663HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    MMP16
  • Uniprot No.:
  • 別名:
    MMP16; C8orf57; MMPX2; Matrix metalloproteinase-16; MMP-16; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達(dá)區(qū)域:
    120-607
  • 氨基酸序列
    YALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
  • 基因功能參考文獻(xiàn):
    1. Overexpression of MMP2 and MMP16 in endometrial cancerous tissues corresponded to down-regulation of miR-377, miR-382 and miR-410, while decreased expression of TIMP2 was associated with miR-200b up-regulation. PMID: 28871006
    2. MMP16 was highly expressed and correlated with poor prognosis in gastric cancer patients by promoting proliferation and invasion of gastric cancer cells PMID: 27340864
    3. the present findings indicate that MT3-MMP is down-regulated in ESCC, which correlates to lymph node metastasis and poor survival of patients with this disease. PMID: 27292876
    4. more severe intervertebral disc degeneration is correlated with higher matrix metallopeptidase 16 PMID: 27227700
    5. results suggest that miR-145 functions as a tumor metastasis suppressor gene by down-regulating MMP16 and may be a potential target in osteosarcoma treatment PMID: 26605780
    6. the results support a role for MMP16 in promoting invasive properties of the meningioma tumours PMID: 24989599
    7. These results demonstrate that the MT3-MMP promoter is frequently hypermethylated in colorectal cancer and that downregulation of MT3-MMP may be important for cell migration in colorectal cancer. PMID: 26002729
    8. MMP16 is a putative indicator of adverse melanoma prognosis. PMID: 25808867
    9. Expression of MMP-16 in HTB9 and T24 cells increases following transforming growth factorbeta1 treatment. PMID: 25017509
    10. E2F1 acts as a transcriptional activator for MMPs and directly enhances MMP transcription by binding to E2F1 binding sequences in the promoter, or indirectly activates MMPs (MMP-9 and MMP-16)through enhanced Sp1 and NF-kappa B PMID: 24755270
    11. Matrix metalloproteinase 16 (MMP16) was a downstream target of miR-146b-5p. PMID: 21823013
    12. The overexpression of miR-146b-5p in glioblastoma cell lines led to MMP16 mRNA silencing, MMP2 inactivation, and the inhibition of tumour cell migration and invasion. PMID: 23796692
    13. Data show that MMP16 is regulated by miR-146a in spontaneously differentiated Caco-2 cells. PMID: 22348245
    14. MT3-MMP is a matrix-dependent modifier of the invasive tumor cell functions during melanoma progression PMID: 22164270
    15. Results report the structure of the catalytic domain (cd) of the membrane-type matrix metalloproteinase MT3-MMP/MMP-16 in complex with the hydroxamic acid inhibitor batimastat. PMID: 14741217
    16. MT3-MMP is not only important in matrix degradation but also may affect the function of focal adhesions through FAK cleavage. PMID: 15044209
    17. Type-3 metalloproteinases, are identified as the triggering agents that independently confer cancer cells with the ability to proteolytically efface the BM scaffolding, initiate the assembly of invasive pseudopodia, and propagate transmigration. PMID: 16983145
    18. Chondroitin-4-sulfate, which is expressed on tumour cell surface, can function to bind to pro-MMP-2 and facilitate its activation by MT3-MMP-expressing tumour cells to enhance invasion and metastasis PMID: 17217338
    19. We have demonstrated the expression of MT3-MMP in hepatocellular carcinoma tissues (HCC) and that the expression in HCC significantly correlates with capsular invasion. PMID: 17419254
    20. MMP16 polymorphisms appear to influence not only the pulmonary expression and function of MMP16 but also the risk of bronchopulmonary dysplasia PMID: 18784838
    21. miR-146b is involved in glioma cell migration and invasion by targeting MMP16; implicating miR-146b as a metastasis-inhibiting miRNA in glioma PMID: 19265686

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform Long]: Cell membrane; Single-pass type I membrane protein; Extracellular side. Note=Localized at the cell surface of melanoma cells.; [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.
  • 蛋白家族:
    Peptidase M10A family
  • 組織特異性:
    Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7162

    OMIM: 602262

    KEGG: hsa:4325

    STRING: 9606.ENSP00000286614

    UniGene: Hs.492187



主站蜘蛛池模板: 激情人妻另类人妻伦| 中文字幕精品亚洲无线码vr| 人妻三级日本三级日本三级极| 久久精品久久久久观看99水蜜桃 | 天天看片视频免费观看| 人妻少妇无码精品专区| 欧美性猛交xxxx乱大交蜜桃| 国产免费久久精品99久久| 亚洲偷自拍国综合| 中文字幕av伊人av无码av狼人| 免费无码肉片在线观看| 国产亚洲精品久久久久久无几年桃| 在线人人车操人人看视频| 成 人影片 免费观看在线| 日本黄页网站免费大全| 一区二区乱子伦在线播放| 日韩精品无码中文字幕一区二区| 国产1卡二卡3卡四卡乱码视频| 女人夜夜春精品a片| 国精品人妻无码一区二区三区喝尿| 狠狠精品久久久无码中文字幕| 激情国产av做激情国产爱| 97精品国产手机| 亚洲欧美日韩中文无线码| 国产精品久免费的黄牛仔短裤| 国产在线精品一区在线观看| 国产精品99久久久精品无码| 日日拍夜夜嗷嗷叫|日日摸| 最新无码a∨在线观看| 成年男女免费视频网站| 久久9精品区-无套内射无码| 欧洲精品va无码一区二区三区| 一本久久精品一区二区| 人妻少妇被粗大爽9797pw| 日本高清色www网站色噜噜噜| 国产在线视频主播区| 中文字幕色av一区二区三区| 99热成人精品国产免费| 无套熟女av呻吟在线观看| 欧美人与动牲交a欧美| 爆乳高潮喷水无码正在播放 |