在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MMP16 Antibody

MMP16 Antibody

  • 中文名稱：
    MMP16兔多克隆抗體
  • 貨號：
    CSB-PA598539
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA598539(MMP16 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MMP16
  • 別名：
    MMP16; C8orf57; MMPX2; Matrix metalloproteinase-16; MMP-16; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human MMP16
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
  • 基因功能參考文獻：
    1. Overexpression of MMP2 and MMP16 in endometrial cancerous tissues corresponded to down-regulation of miR-377, miR-382 and miR-410, while decreased expression of TIMP2 was associated with miR-200b up-regulation. PMID: 28871006
    2. MMP16 was highly expressed and correlated with poor prognosis in gastric cancer patients by promoting proliferation and invasion of gastric cancer cells PMID: 27340864
    3. the present findings indicate that MT3-MMP is down-regulated in ESCC, which correlates to lymph node metastasis and poor survival of patients with this disease. PMID: 27292876
    4. more severe intervertebral disc degeneration is correlated with higher matrix metallopeptidase 16 PMID: 27227700
    5. results suggest that miR-145 functions as a tumor metastasis suppressor gene by down-regulating MMP16 and may be a potential target in osteosarcoma treatment PMID: 26605780
    6. the results support a role for MMP16 in promoting invasive properties of the meningioma tumours PMID: 24989599
    7. These results demonstrate that the MT3-MMP promoter is frequently hypermethylated in colorectal cancer and that downregulation of MT3-MMP may be important for cell migration in colorectal cancer. PMID: 26002729
    8. MMP16 is a putative indicator of adverse melanoma prognosis. PMID: 25808867
    9. Expression of MMP-16 in HTB9 and T24 cells increases following transforming growth factorbeta1 treatment. PMID: 25017509
    10. E2F1 acts as a transcriptional activator for MMPs and directly enhances MMP transcription by binding to E2F1 binding sequences in the promoter, or indirectly activates MMPs (MMP-9 and MMP-16)through enhanced Sp1 and NF-kappa B PMID: 24755270
    11. Matrix metalloproteinase 16 (MMP16) was a downstream target of miR-146b-5p. PMID: 21823013
    12. The overexpression of miR-146b-5p in glioblastoma cell lines led to MMP16 mRNA silencing, MMP2 inactivation, and the inhibition of tumour cell migration and invasion. PMID: 23796692
    13. Data show that MMP16 is regulated by miR-146a in spontaneously differentiated Caco-2 cells. PMID: 22348245
    14. MT3-MMP is a matrix-dependent modifier of the invasive tumor cell functions during melanoma progression PMID: 22164270
    15. Results report the structure of the catalytic domain (cd) of the membrane-type matrix metalloproteinase MT3-MMP/MMP-16 in complex with the hydroxamic acid inhibitor batimastat. PMID: 14741217
    16. MT3-MMP is not only important in matrix degradation but also may affect the function of focal adhesions through FAK cleavage. PMID: 15044209
    17. Type-3 metalloproteinases, are identified as the triggering agents that independently confer cancer cells with the ability to proteolytically efface the BM scaffolding, initiate the assembly of invasive pseudopodia, and propagate transmigration. PMID: 16983145
    18. Chondroitin-4-sulfate, which is expressed on tumour cell surface, can function to bind to pro-MMP-2 and facilitate its activation by MT3-MMP-expressing tumour cells to enhance invasion and metastasis PMID: 17217338
    19. We have demonstrated the expression of MT3-MMP in hepatocellular carcinoma tissues (HCC) and that the expression in HCC significantly correlates with capsular invasion. PMID: 17419254
    20. MMP16 polymorphisms appear to influence not only the pulmonary expression and function of MMP16 but also the risk of bronchopulmonary dysplasia PMID: 18784838
    21. miR-146b is involved in glioma cell migration and invasion by targeting MMP16; implicating miR-146b as a metastasis-inhibiting miRNA in glioma PMID: 19265686

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform Long]: Cell membrane; Single-pass type I membrane protein; Extracellular side. Note=Localized at the cell surface of melanoma cells.; [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.
  • 蛋白家族：
    Peptidase M10A family
  • 組織特異性：
    Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7162

    OMIM: 602262

    KEGG: hsa:4325

    STRING: 9606.ENSP00000286614

    UniGene: Hs.492187



主站蜘蛛池模板： 欧美午夜成人片在线观看| 精品国产一区二区三区av片 | 精品国产va久久久久久久冰| 五月av综合av国产av| 久久亚洲一区二区三区四区五区 | 久久综合a∨色老头免费观看| 日韩中文亚洲欧美视频二| 国产成人精品日本亚洲专区61| 国产精品亚洲一区二区在线观看| 蜜臀久久99精品久久久久久做爰| 国产欧美国日产高清| 亚洲熟妇av一区二区三区漫画| 欧美性生交xxxxx久久久| 日本在线a一区视频| 韩日综合成人中文字幕| 久久久久亚洲精品无码网址| 国产亚洲精品97在线视频一| 丰满少妇被粗大猛烈进人高清| 乱码国产丰满人妻www| 欧美三级韩国三级日本三斤| 丝袜高跟麻麻浓精受孕人妻| 熟女丝袜潮喷内裤视频网站| 少妇仑乱a毛片| 日本高清www午色夜com| 国产v综合v亚洲欧| 好疼太大了太粗太长了视频| 十八18禁国产精品www | 欧美国产精品久久久乱码| 极品少妇高潮到爽| 女人裸体做爰免费视频| 一本一道av中文字幕无码| 欧美丰满美乳xxⅹ高潮www | 精品人妻一区二区三区四区| 中文字幕+乱码+中文乱码www| 国产亚洲欧洲aⅴ综合一区| 少妇饥渴xxhd麻豆xxhd骆驼| 无遮挡激情视频国产在线观看| 国产av巨作丝袜秘书| 国产亚洲精品精品精品| 国产一区二区野外| 亚洲男男无套gv大学生|