在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Erlin-1 (ERLIN1)-VLPs

  • 中文名稱:
    人ERLIN1重組蛋白
  • 貨號:
    CSB-MP007790HU
  • 規格:
  • 其他:

產品詳情

  • 基因名:
    ERLIN1
  • Uniprot No.:
  • 別名:
    ERLIN1; C10orf69; KE04; KEO4; SPFH1; Erlin-1; Endoplasmic reticulum lipid raft-associated protein 1; Protein KE04; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1; SPFH domain-containing protein 1
  • 種屬:
    Homo sapiens (Human)
  • 來源:
    Mammalian cell
  • 表達區域:
    1-348aa
  • 氨基酸序列
    MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIRTGRESSLPSKEALEPSGENVIQNKESTG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it’s possible to develop.
  • 產品提供形式:
    Lyophilized powder
    Note: We will default ship it in lyophilized form with normal bule ice packs. However, if you request to ship in liquid form, it needs to be shipped with dry ice, please communicate with us in advance and extra fees for dry ice and dry ice box will be charged.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.; (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production.
  • 基因功能參考文獻:
    1. Erlin-1 and the related erlin-2 were found to selectively bind cholesterol. Knockdown of the proteins by RNAi in cultured cells resulted in high levels of cholesterol and fatty acid biosynthesis in the presence of cholesterol sufficiency. PMID: 24217618
    2. Here we show that the multimeric ER proteins erlins-1 and -2 are additional sterol regulatory element binding protein regulators. PMID: 24217618
    3. Our findings suggest ERLIN1-CHUK-CWF19L1 variants are associated with early stage of fatty liver accumulation to hepatic inflammation. PMID: 23477746
    4. Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. PMID: 16835267
    5. Results suggest that this novel SPFH1/2 complex is a recognition factor that targets IP(3)Rs and perhaps other substrates for ERAD. PMID: 19240031
    6. m3 receptor-expressing HeLa cells are a valuable system for studying IP(3) receptor ERAD, and suggest that the SPFH1/2 complex is a factor that selectively mediates the ERAD of activated IP(3) receptors. PMID: 19751772

    顯示更多

    收起更多

  • 相關疾病:
    Spastic paraplegia 62, autosomal recessive (SPG62)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
  • 蛋白家族:
    Band 7/mec-2 family
  • 組織特異性:
    Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.
  • 數據庫鏈接:

    HGNC: 16947

    OMIM: 611604

    KEGG: hsa:10613

    STRING: 9606.ENSP00000384900

    UniGene: Hs.150087



主站蜘蛛池模板: 三级在线看中文字幕完整版| 久久九九久精品国产免费直播| 性生交大片免费看女人按摩| 日韩免费无码一区二区视频| 麻豆av字幕无码中文| 粗大的内捧猛烈进出看视频| 熟妇高潮精品一区二区三区| 日韩成人无码一区二区三区| 狠狠色噜噜狠狠色综合久| 欧美精品1卡二卡三卡四卡 | 国产3p露脸普通话对白| 欧美疯狂性受xxxxx另类| 天天摸日日摸爽爽狠狠| 国产午夜福利精品一区| 欧美无遮挡很黄裸交视频| 国产精品视频免费播放| 18禁勿入网站入口永久| 国产成人a在线观看视频| 国产精品美女久久久网站| 国产 麻豆 日韩 欧美 久久| 国产av一区二区三区无码野战| 男女做爰无遮挡性视频| 麻豆av一区二区三区| 精品无人乱码一区二区三区的特点| 99精品丰满人妻无码a片| 欧美人与动牲交免费观看| 国产真实乱对白精彩久久老熟妇女| 国内精品视频自在一区| 亚洲中字幕日产av片在线| 99国产精品久久久久久久成人热| 亚洲欧美一区二区三区在线| 2020国产亚洲美女精品久久久| 色欲久久久中文字幕综合网| 中出人妻中文字幕无码| 亚洲欧美日韩二三区在线| 影音先锋啪啪av资源网站| 国产熟妇久久777777| 国产成人综合久久精品推下载| 国产一区精选播放022| 亚洲愉拍自拍欧美精品| 色婷婷久久一区二区三区麻豆|