在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human E3 ubiquitin-protein ligase RNF128 (RNF128)

  • 中文名稱:
    人RNF128重組蛋白
  • 貨號:
    CSB-CF837448HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    RNF128
  • Uniprot No.:
  • 別名:
    RNF128; E3 ubiquitin-protein ligase RNF128; Gene related to anergy in lymphocytes protein; GRAIL; RING finger protein 128; RING-type E3 ubiquitin transferase RNF128
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達(dá)區(qū)域:
    39-428
  • 氨基酸序列
    AEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNP HTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPM SHPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFII TAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCA VCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSL QVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSV AVDVIPHVDNPTFEEDETPNQETAVREIKS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
  • 基因功能參考文獻(xiàn):
    1. results show that expression of GRAIL is uniquely regulated by the specific miRNA in intestinal mucosa, and suggest that GRAIL may associate with the pathophysiology of Crohn's disease PMID: 24356810
    2. study shows that Grail has a novel, p53-dependent role in regulating the cell cycle and apoptosis PMID: 23370271
    3. Forced expression of GRAIL in a T cell line from a T-cell receptor transgenic mouse is sufficient for conversion of these cells to a regulatory phenotype. PMID: 17259178
    4. Inhibition of T cell activation is not due to apoptosis or disruption of proximal T- cell receptor signaling, but is associated with up-regulation of GRAIL in CD4+ T cells, with modest effects on other E3 ubiquitin ligases. PMID: 17475842
    5. GRAIL expression was significantly higher in patients with ulcerative colitis in remission than in patients with active disease and in healthy volunteers. PMID: 18467499
    6. GRAIL captures and then ubiquitinates transmembrane proteins across the cell membrane PMID: 18713730
    7. endogenous GRAIL regulates general cell cycle and proliferation of primary naive CD4 T cells. PMID: 19414743
    8. GRAIL can down-modulate the expression of CD83 antigen on CD4 T cells. PMID: 19542455

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 21153

    OMIM: 300439

    KEGG: hsa:79589

    STRING: 9606.ENSP00000255499

    UniGene: Hs.496542



主站蜘蛛池模板: 人人超碰人人超级碰国| 国产 一二三四五六| 国产精品无码一区二区三区 | 亚洲熟女久久色| 人妻 偷拍 无码 中文字幕| 狠狠色噜噜狠狠狠888米奇| 国产a在亚洲线播放| 国产精品亚洲一区二区在线观看| 亚洲国产av天码精品果冻传媒| 人妻丰满熟妇av无码区动漫| 欧美极品少妇无套实战| 欧美丰满熟妇xxxxx| 国产精品亚洲精品一区二区| 99亚洲精品自拍av成人| 超碰免费公开| 精品人伦一区二区三区潘金莲 | 97在线成人国产在线视频| 50岁熟妇的呻吟声对白| 亚洲国产精品综合久久20| 又污又爽又黄的网站| 一个色综合国产色综合| 国产女厕所盗摄老师厕所嘘嘘| 免费无码一区二区三区a片百度| 欧美乱色伦图片区| 久久精品国产亚洲a片高清不卡| 成人影院永久免费观看网址| 欧美日韩不卡合集视频| 亚洲成av人片在线观看| 久久国产精品萌白酱免费| 久久综合色老色| 九九久久精品无码专区| 亚洲日韩久热中文字幕| 亚洲国产精品无码一区二区三区| 国产精品自在拍在线拍| 国模少妇一区二区三区| 中文字幕无码精品三级在线电影| 亚洲成年轻人电影网站www| 国产成人久久婷婷精品流白浆| 色狠狠av一区二区三区| 97色伦午夜国产亚洲精品| 日韩丰满少妇无码内射|