在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF128 Antibody

RNF128 Antibody

  • 中文名稱：
    RNF128兔多克隆抗體
  • 貨號：
    CSB-PA837448LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: RNF128 antibody at 12µg/ml + Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 47, 45 kDa
      Observed band size: 47 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA837448LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RNF128 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF128
  • 別名：
    RNF128; E3 ubiquitin-protein ligase RNF128; Gene related to anergy in lymphocytes protein; GRAIL; RING finger protein 128; RING-type E3 ubiquitin transferase RNF128
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF128 protein (229-400AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，RNF128 Antibody (CSB-PA837448LA01HU)，的標記方式是Non-conjugated。對于RNF128 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA837448LB01HU RNF128 Antibody, HRP conjugated ELISA
    FITC CSB-PA837448LC01HU RNF128 Antibody, FITC conjugated
    Biotin CSB-PA837448LD01HU RNF128 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
  • 基因功能參考文獻：
    1. results show that expression of GRAIL is uniquely regulated by the specific miRNA in intestinal mucosa, and suggest that GRAIL may associate with the pathophysiology of Crohn's disease PMID: 24356810
    2. study shows that Grail has a novel, p53-dependent role in regulating the cell cycle and apoptosis PMID: 23370271
    3. Forced expression of GRAIL in a T cell line from a T-cell receptor transgenic mouse is sufficient for conversion of these cells to a regulatory phenotype. PMID: 17259178
    4. Inhibition of T cell activation is not due to apoptosis or disruption of proximal T- cell receptor signaling, but is associated with up-regulation of GRAIL in CD4+ T cells, with modest effects on other E3 ubiquitin ligases. PMID: 17475842
    5. GRAIL expression was significantly higher in patients with ulcerative colitis in remission than in patients with active disease and in healthy volunteers. PMID: 18467499
    6. GRAIL captures and then ubiquitinates transmembrane proteins across the cell membrane PMID: 18713730
    7. endogenous GRAIL regulates general cell cycle and proliferation of primary naive CD4 T cells. PMID: 19414743
    8. GRAIL can down-modulate the expression of CD83 antigen on CD4 T cells. PMID: 19542455

    顯示更多

    收起更多

  • 亞細胞定位：
    Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region.
  • 數據庫鏈接：

    HGNC: 21153

    OMIM: 300439

    KEGG: hsa:79589

    STRING: 9606.ENSP00000255499

    UniGene: Hs.496542



主站蜘蛛池模板： 99精品国产福利在线观看| 欧洲女人性开放免费网站| 国模无码一区二区三区不卡| 亚洲aⅴ天堂av天堂无码app| 99久久精品6在线播放| 国产精品国产三级国av在线观看 | 无码国产玉足脚交极品播放| 久久99精品国产99久久6| 国产成人啪精品视频网站午夜| 小宝极品内射国产在线| 熟女内射v888av| 极品少妇hdxx麻豆hdxx| 综合在线 亚洲 成人 欧美| 99久久免费国产精品四虎| 日本三级带日本三级带黄| 亚洲欧洲精品成人久久曰影片| 亚洲日韩国产av无码无码精品| 竹菊影视欧美日韩一区二区三区四区五区 | 亚洲韩国日本高清一区| 中文字幕日韩人妻不卡一区| 一本加勒比hezyo无码人妻| 亚洲日韩乱码久久久久久| 琪琪电影午夜理论片八戒八戒| 国产成人午夜福利在线小电影| 国产啪精品视频网站免| 亚洲a无码综合a国产av中文| 成 人 色 网 站免费观看| 色婷婷久久综合中文久久一本| 中文人妻熟妇乱又伦精品| 亚洲国产成人久久精品99| 欧美日韩亚洲精品瑜伽裤| 久久精品国产亚洲精品| 五月丁香综合缴情六月小说| 人人澡人人妻人人爽人人蜜桃麻豆| 日本熟人妻中文字幕在线| 国产av一区最新精品| 婷婷色婷婷开心五月| 成人免费视频在线观看地区免下载 | 欧美成人高清视频a在线看| 国产涩涩视频在线观看| 成人区人妻精品一区二区三区|