在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Claudin-11 (CLDN11)

In Stock
  • 中文名稱:
    Recombinant Human Claudin-11(CLDN11)
  • 貨號:
    CSB-CF005492HU
  • 規格:
    ¥9720
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    CLDN11
  • Uniprot No.:
  • 別名:
    (Oligodendrocyte-specific protein)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    in vitro E.coli expression system
  • 分子量:
    23.5 kDa
  • 表達區域:
    1-207aa
  • 氨基酸序列
    MVATCLQVVGFVTSFVGWIGVIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYYTAGSSSPTHAKSAHV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻:
    1. expression of claudin-11 in cutaneous squamous cell carcinoma (cSCC) cells depended on the activity of p38delta MAPK; knock-down of claudin-11 enhanced cSCC cell invasion PMID: 27992079
    2. Authors demonstrated that CLDN11 promoter hypermethylation is a frequent event in LSCC, and contributes to metastasis and progression of LSCC. PMID: 28743857
    3. The expression of claudin-11, -23 was remarkably downregulated in gastric cancer. PMID: 28350854
    4. Claudin-11 might represent the essential component of the blood-testis barrier in human. PMID: 27486954
    5. the expression of miR-99b was inversely correlated with CLDN11 levels . These findings suggest that a high level of miR-99b expression is an independent prognostic factor and correlates with poor survival of patients with Hepatocellular carcinoma (HCC) PMID: 26134929
    6. CLDN11 is an epigenetic biomarker for malignancy in dysplastic nevus and melanoma. PMID: 24999589
    7. these data suggest that cancer cells may induce CLDN11 overexpression and subsequent collective migration of peritumoral CAFs via TGF-beta secretion. PMID: 24268521
    8. The expression of claudin-11 was up regulated in gastric cancer tissue. PMID: 23919729
    9. The spatial organization of claudin-11 and connexin-43 is altered in men with primary seminiferous tubule failure. PMID: 23706332
    10. disorganization of claudin-11 expression in Sertoli cells might be one of the factors involved in the impairment of spermatogenesis. PMID: 22951003
    11. Treatment with 3-deazaneplanocin A, an inhibitor of H3K27 methyltransferase, attenuated CLDN11 induction by serum stimulation in parallel with sustained miR-1275 expression PMID: 22736761
    12. claudin-11 may have a role in preventing cancer progression and may serve as a therapeutic target in reducing metastasis PMID: 21468549
    13. late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the blood testis barrier in the human testis PMID: 20850723
    14. Claudins 11,expression in meningiomas. PMID: 20546350
    15. hypermethylation of CLDN11, leading to downregulated expression, contributes to gastric carcinogenesis by increasing cellular motility and invasiveness PMID: 19956721
    16. Contribution of the tight junction protein CLDN11 to barrier function in endothelial cells is novel and may reflect hemodynamic requirements of the corpus cavernosum. PMID: 19622796
    17. Data demonstrate that in rhesus monkeys immune responses directed at human OSP are encephalitogenic, leading to inflammatory responses throughout the central nervous system and to selective demyelination of the optic nerve. PMID: 18412169
    18. the disruption of the blood-testis barrier is related to a dysfunction of claudin-11 and not to a failure of its expression. PMID: 19241088

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Claudin family
  • 數據庫鏈接:

    HGNC: 8514

    OMIM: 601326

    KEGG: hsa:5010

    STRING: 9606.ENSP00000064724

    UniGene: Hs.31595



主站蜘蛛池模板: 国产在不卡免费一区二区三| 久久99精品久久久大学生| 婷婷国产成人精品视频| 中国xxxx做受视频| 日本wv一本一道久久香蕉| 亚洲熟女av乱码在线观看漫画| 人人澡人人妻人人爽人人蜜桃| 国产精品丝袜一区二区三区| 国产成人精品综合久久久久| 国产欧美日韩一区2区| 国产精品无码a∨果冻传媒| 国产成人亚洲精品无码青青草原| 狠狠色噜噜狠狠狠888米奇| 国产成人久久精品二区三区 | 国产熟妇高潮叫床视频播放| 人妻精品久久久久中文字幕| 99热亚洲色精品国产88| 日本无码一区二区三区不卡免费| 国产乱色国产精品播放视频| 成人午夜视频精品一区| 国产99久久九九精品无码| 午夜伦4480yy私人影院久久| 少妇高潮喷水惨叫久久久久电影| 亚洲精品国产精品国自产| 亚洲国产成人久久综合下载| 亚洲欧美在线制服丝袜国产| 国产国产精品人在线视| 亚洲人av高清无码| 四虎国产精亚洲一区久久特色| 综合 欧美 小说 另类 图| 日本猛少妇色xxxxx猛叫| 波多野结衣网站| 久久人人超碰精品caoporen| 制服丝袜另类专区制服| 国产成人无码av在线播放dvd| 国产精品进线69影院| 国产区精品一区二区不卡中文| 精品 在线 视频 亚洲| 狠狠色综合网丁香五月| 成人无码免费视频在线播| 亚洲中国精品精华液|