在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CLDN11 Antibody

  • 中文名稱:
    CLDN11兔多克隆抗體
  • 貨號:
    CSB-PA020196
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CLDN11
  • 別名:
    CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human Claudin-11.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻:
    1. expression of claudin-11 in cutaneous squamous cell carcinoma (cSCC) cells depended on the activity of p38delta MAPK; knock-down of claudin-11 enhanced cSCC cell invasion PMID: 27992079
    2. Authors demonstrated that CLDN11 promoter hypermethylation is a frequent event in LSCC, and contributes to metastasis and progression of LSCC. PMID: 28743857
    3. The expression of claudin-11, -23 was remarkably downregulated in gastric cancer. PMID: 28350854
    4. Claudin-11 might represent the essential component of the blood-testis barrier in human. PMID: 27486954
    5. the expression of miR-99b was inversely correlated with CLDN11 levels . These findings suggest that a high level of miR-99b expression is an independent prognostic factor and correlates with poor survival of patients with Hepatocellular carcinoma (HCC) PMID: 26134929
    6. CLDN11 is an epigenetic biomarker for malignancy in dysplastic nevus and melanoma. PMID: 24999589
    7. these data suggest that cancer cells may induce CLDN11 overexpression and subsequent collective migration of peritumoral CAFs via TGF-beta secretion. PMID: 24268521
    8. The expression of claudin-11 was up regulated in gastric cancer tissue. PMID: 23919729
    9. The spatial organization of claudin-11 and connexin-43 is altered in men with primary seminiferous tubule failure. PMID: 23706332
    10. disorganization of claudin-11 expression in Sertoli cells might be one of the factors involved in the impairment of spermatogenesis. PMID: 22951003
    11. Treatment with 3-deazaneplanocin A, an inhibitor of H3K27 methyltransferase, attenuated CLDN11 induction by serum stimulation in parallel with sustained miR-1275 expression PMID: 22736761
    12. claudin-11 may have a role in preventing cancer progression and may serve as a therapeutic target in reducing metastasis PMID: 21468549
    13. late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the blood testis barrier in the human testis PMID: 20850723
    14. Claudins 11,expression in meningiomas. PMID: 20546350
    15. hypermethylation of CLDN11, leading to downregulated expression, contributes to gastric carcinogenesis by increasing cellular motility and invasiveness PMID: 19956721
    16. Contribution of the tight junction protein CLDN11 to barrier function in endothelial cells is novel and may reflect hemodynamic requirements of the corpus cavernosum. PMID: 19622796
    17. Data demonstrate that in rhesus monkeys immune responses directed at human OSP are encephalitogenic, leading to inflammatory responses throughout the central nervous system and to selective demyelination of the optic nerve. PMID: 18412169
    18. the disruption of the blood-testis barrier is related to a dysfunction of claudin-11 and not to a failure of its expression. PMID: 19241088

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Claudin family
  • 數據庫鏈接:

    HGNC: 8514

    OMIM: 601326

    KEGG: hsa:5010

    STRING: 9606.ENSP00000064724

    UniGene: Hs.31595



主站蜘蛛池模板: 人妻av无码系列专区移动可看| 性欧美大胆免费播放| 人妻无码一区二区三区 tv| 国产成人亚洲综合无码18禁h| 波多野结av在线无码中文| 国产精品中文久久久久久久| 看曰本女人大战黑人视频| 国产欧美成人xxx视频| 亚洲精品久久一区二区无卡| av小次郎收藏| 无码人妻一区二区三区免费看| 久久精品女人的天堂av| 久久国产精品人妻丝袜| 国产免费牲交视频| 亚洲精品成人无限看| 免费香蕉成视频人网站| 男女做爰无遮挡性视频| 精品国产亚洲一区二区三区| 色偷一区国产精品| 狠狠躁夜夜躁无码中文字幕| 99热精品毛片全部国产无缓冲| 97久久精品人人澡人人爽| 最新69国产成人精品视频免费| 色舞月亚洲综合一区二区| 伊人久久精品无码二区麻豆| 国产精品夜间视频香蕉| 午夜福利精品亚洲不卡| 最近最好的中文字幕2019免费| 国产精品v欧美精品v日韩精品| 人人爽人人澡人人高潮| 亚洲精品无码不卡在线播放he| 亚洲成av人片在线观看无| 亚洲精品国产一区二区贰佰信息网| 亚洲一区二区三区在线观看网站| 最近最好的中文字幕2019免费 | 色婷婷综合久久久中文字幕| 快好爽射给我视频| 精品免费国产一区二区| 亚洲欧美色中文字幕在线| 青娱乐极品视觉盛宴国产视频| 美女人妻激情乱人伦|