在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Alkaline ceramidase 3 (ACER3)

  • 中文名稱:
    Recombinant Human Alkaline ceramidase 3(ACER3)
  • 貨號(hào):
    CSB-CF001153HU
  • 說明書:
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    ACER3
  • Uniprot No.:
  • 別名:
    ACER3; APHC; PHCA; Alkaline ceramidase 3; AlkCDase 3; Alkaline CDase 3; Alkaline dihydroceramidase SB89; Alkaline phytoceramidase; aPHC
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-267
  • 氨基酸序列
    MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLE KRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYH LLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLG IFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRT LYLRYRPKVKFLFGIWPVILFEPLRKH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response.
  • 基因功能參考文獻(xiàn):
    1. Our study suggests that Acer3 contributes to hepatocellular carcinoma propagation PMID: 30097213
    2. Homozygosity for the p.E33G mutation in the ACER3 gene results in inactivation of ACER3. PMID: 26792856
    3. The ACER3 deficiency resulted in decreased cell growth and colony formation, elevated apoptosis, and lower AKT signaling of leukemia cells. This study indicates that ACER3 contributes to AML pathogenesis, and suggests that alkaline ceramidase inhibition is an option to treat acute myeloid leukemia. PMID: 27470583
    4. ACER3 catalyzes the hydrolysis of unsaturated long chain ceramides and dihydroceramides and coordinates with ACER2 to regulate cell proliferation and survival PMID: 20068046
  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Alkaline ceramidase family
  • 組織特異性:
    Ubiquitously expressed. Highly expressed in placenta. Expressed in erythrocytes.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16066

    KEGG: hsa:55331

    STRING: 9606.ENSP00000434480

    UniGene: Hs.23862



主站蜘蛛池模板: 激情欧美日韩一区二区| 色欲av永久无码精品无码| 国产亚洲视频在线观看播放| 人妻少妇乱子伦精品| 久久久国产精品无码一区二区| 伊人久久大香线蕉成人| 日本少妇被黑人猛cao| 少妇系列之白嫩人妻| 丁香五香天堂网| 午夜精品久久久内射近拍高清| a在线亚洲男人的天堂| 黑人与中国少妇xxxx视频| 色综合久久久久久久久五月| 四虎免费大片aⅴ入口| 精品人妻一区二区三区四区| 久久久久77777人人人人人| 国产成人av区一区二区三| 色噜噜噜亚洲男人的天堂| 在线观看免费人成视频| 国产精品久久..4399| 亚洲 激情 小说 另类 欧美| 成在人线av无码免费高潮喷水 | 亚洲熟伦熟女新五十路熟妇| 99久久久国产精品无码免费| 人人玩人人添人人澡超碰偷拍| 日本亚洲欧洲另类图片| 亚洲人成网站18禁止中文字幕| 国模吧无码一区二区三区| 色翁荡息又大又硬又粗又爽电影| 冲田杏梨av一区二区三区| 无码精品人妻一区二区三区98| 亚洲伊人成无码综合网| 国产亚洲精品无码成人| 四虎影视国产精品久久| 日韩人妻无码精品系列| 国产精品亚洲а∨无码播放麻豆| 风间由美性色一区二区三区| 欧美交换配乱吟粗大25p | 日韩免费人妻av无码专区蜜桃| 激情综合丁香五月| 苍井空张开腿实干12次|