在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Drosophila melanogaster Otefin (Ote)

  • 中文名稱:
    黑腹果蠅Ote重組蛋白
  • 貨號:
    CSB-CF321785DLU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    Ote
  • Uniprot No.:
  • 別名:
    Ote; CG5581; Otefin; LEM domain-containing protein Otefin
  • 種屬:
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-424
  • 氨基酸序列
    MADVDDFDSLSNAELRAKMLAQGLPNIPVTDSSRKVLVKRLRASIGGQASPAASPKKTNR RETLAPAPGAPSAPAAASTPVDKLDGNKVAPATKARRTITAAEAKEPVRRLPEEAIRRRP DEADRLRSEEPVAARKPTTAPAAQPVQTRRTSTSSGSERKVVEPLRKPETIVEQPASSKR ADREENYLKVNSLIVLESDEEEDEQLVQAADLVEQEHAARQKTTKLASSGTTTYEYKSKV VEPPRRQVYEATAAPVLPPSVPSARAQTTSSTRSYDYASNPAPGRYSSFVRTAAQGYVTA EAPPVASYSSSYKRTYANELSDDTDSKEDQYESTFARNLARLRAERIGDRISPYSRRTLA SGNAGSGSLGYEPRARRSLRPNDNSVSEAFNRWLNSLEQKYHIKSKLFIVLLVLLLIGVY YIFY
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Inner nuclear membrane protein. Involved in the attachment of membrane vesicles to chromatin during nuclear assembly, and is probably required for centrosome maturation and cell cycle progression during mitosis. Essential for differentiation of certain tissues and the maintenance of progenitor cell populations. Required for the differentiation and maintenance of male and female germline stem cells (GSCs), as well as the maintenance of somatic cells in the GSC niche. This role is likely to be independent of the BMP (Dpp) pathway that negatively regulates bam transcription during GSC differentiation. During development, plays essential and redundant functions with the other LEM domain proteins; bocks and MAN1. Also has a redundant but important role with bocks during larval development.
  • 基因功能參考文獻:
    1. Ote is required autonomously for survival of male and female stem cell populations, as well as non-autonomously for maintenance of two somatic niches. Ote loss in ovary causes a decrease in cap cell number and altered signal transduction. Ote mutant males become prematurely sterile as they age. PMID: 27174470
    2. production of Bocks, but not dMAN1, rescued ote-/- sterility, demonstrating that Ote and Bocks are functional homologs PMID: 24700158
    3. We show that the primary defect in ote(-/-) GSCs is a block of differentiation, which ultimately leads to germ cell death. PMID: 23806619
    4. Phosphorylation of Ote at T63 is critical for mitotic progression. PMID: 22751930
    5. Data show that otefin is essential for germline stem cell (GSC) maintenance, is required for the Dpp/BMP signaling pathway to silence bam transcription, and that Ote physically interacts with Medea/Smad4 at the bam silencer element to regulate GSC fate. PMID: 18410727

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nucleoplasm. Cytoplasm. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 組織特異性:
    Expressed in all cell types of the germarium and testis. Expressed in nurse cells, follicle cells and oocytes.
  • 數據庫鏈接:

    KEGG: dme:Dmel_CG5581

    STRING: 7227.FBpp0085947

    UniGene: Dm.3658



主站蜘蛛池模板: 久久精品人人爽人人爽| 亚洲精品成av人片天堂无码| 午夜天堂av天堂久久久| 波多野结衣中文字幕一区二区三区| 成人性做爰片免费视频| 好紧好爽好湿别拔出来视频男男| 久久精品66免费99精品| 国产精品爽爽久久久久久无码| 麻豆国产精成人品观看免费| 亚洲成a人片在线观看国产| 国产思思99re99在线观看| 久久久精品欧美一区二区免费| 精品午夜国产福利观看| 国产一区视频一区欧美| 99无码熟妇丰满人妻啪啪| 亚洲日韩精品a∨片无码| 久久午夜夜伦鲁鲁片无码免费| 亚洲午夜无码久久久久小说| 亚洲中文在线精品国产| 成人aaa片一区国产精品| 久久久一本精品99久久精品66| 亚洲a∨精品永久无码| 巨爆乳中文字幕巨爆区巨爆乳无码 | 亚洲成av人片在一线观看| 尤物av无码国产在线看| 少妇被黑人4p到惨叫欧美人| 亚洲精品第一区二区三区| 精品国产sm最大网免费站| 成人麻豆日韩在无码视频| 日本vs亚洲vs韩国一区三区| 国产高清色高清在线观看| 老鲁夜夜老鲁| 图片区小说区激情区偷拍区 | 成人免费无码大片a毛片户外| 国产精品一区二区av不卡| 欧美性大战久久久久久久| 国产福利萌白酱精品tv一区| 免费播放婬乱男女婬视频国产| 丰满少妇熟乱xxxxx视频| 我的公把我弄高潮了视频 | 久久青草成人综合网站|