在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Dog 3-hydroxyacyl-CoA dehydratase 1 (PTPLA)

  • 中文名稱:
    熟悉的犬HACD1重組蛋白
  • 貨號:
    CSB-CF709305DO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    HACD1
  • Uniprot No.:
  • 別名:
    HACD1; PTPLA; Very-long-chain; 3R-3-hydroxyacyl-CoA dehydratase 1; 3-hydroxyacyl-CoA dehydratase 1; HACD1; Protein-tyrosine phosphatase-like member A
  • 種屬:
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-249
  • 氨基酸序列
    MASSEEDGTNGGASEAGEEKEAPGRRRRLGLLATVWLTFYNIAMTAGWLVLAIAMVRFYM EKGTHKGLYKSIQKTLKFFQTFALLEIVHCLIGIVPTSVIVAGVQVSSRIFMVWLITHSI KPIQNEESVVLFLVAWTVTEITRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVVGELL TIYAALPYVKKTGMFSIRLPNKYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLH GEVIVEKDD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
  • 基因功能參考文獻:
    1. Longitudinal analyses in myopathic Labrador retrievers reveal several membrane-associated defects, including ultrastructural triads dysmorphogenesis and mitochondrial mislocalization. PMID: 27939133
    2. Loss of function in myoblasts, knockout mice and spontaneously affected Labrador retrievers leads to reduced myoblast fusion (hypotrophy), associated with modified lipid composition and physical properties of membranes. PMID: 26160855
    3. Labrador retrievers carrying two copies of a unique HACD1 loss-of-function allele that recently disseminated worldwide, are all affected by a congenital myopathy, confirming its role in muscle development. PMID: 23071563
    4. A loss-of-function mutation identified by genetic mapping in a French pedigree of Labrador retrievers causes a congenital myopathy named centronuclear myopathy (CNM). PMID: 15829503
    5. confirm that dogs deficient in HACD1 are relevant models PMID: 27939133
    6. Haplotype analysis demonstrated that the PTPLA(cnm) allele resulted from a single and recent mutational event that may have rapidly disseminated through the extensive use of popular sires PMID: 23071563
    7. Described herein is a disease-associated insertion within PTPLA exon 2, found in both alleles of all affected Labradors and in a single allele in obligate carriers PMID: 15829503

    顯示更多

    收起更多

  • 相關疾病:
    Defects in HACD1 may be the cause of autosomal recessive centronuclear myopathy in Labradors.
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Very long-chain fatty acids dehydratase HACD family
  • 組織特異性:
    Skeletal muscle.
  • 數據庫鏈接:


主站蜘蛛池模板: 成码无人av片在线电影网站| 老湿机69福利区18禁网站| 日韩网红少妇无码视频香港| 熟女精品视频一区二区三区| 国产精品青青在线观看爽香蕉| 高清国产一区二区三区在线| 国产国拍亚洲精品av| 人妻系列无码专区免费视频| 日本免费一区二区三区视频观看| 亚洲成av人片一区二区密柚| 久久夜色撩人精品国产小说 | 免费观看一区二区三区| 成人影片一区免费观看| 中文韩国午夜理伦三级好看| 亚洲欧美成人久久一区 | 欧美午夜精品久久久久免费视| 亚洲日韩成人av无码网站| 久久综合九色综合欧美狠狠| 日本看片一二三区高清| 国内久久婷婷六月综合欲色啪| 欧美午夜一区二区福利视频| 久久久久久久女国产乱让韩| 久久亚洲国产精品亚洲老地址| 男女做爰无遮挡性视频| 亚洲日韩欧洲乱码av夜夜摸 | 人妻aⅴ中文字幕无码| 亚洲精品欧美二区三区中文字幕| 51视频国产精品一区二区| 国产婷婷精品av在线| 色哟哟最新在线观看入口| 国产精品久久久久无码av| 国产爆乳无码一区二区麻豆| 免费无码又爽又刺激一高潮| 国产成人精品999视频| 国产av一区二区精品久久凹凸| 下面一进一出好爽视频| 人人超碰人摸人爱| 久久久精品456亚洲影院| 色妺妺视频网| 国产av综合影院| 成人午夜电影福利免费|