在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Danio rerio Vang-like protein 2 (vangl2)

  • 中文名稱:
    斑馬魚vangl2重組蛋白
  • 貨號:
    CSB-CF837677DIL
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    vangl2; stbm; tri; Vang-like protein 2; Protein strabismus; Protein trilobite; Van Gogh-like protein 2
  • 種屬:
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-526
  • 氨基酸序列
    MDNESQYSGYSYKSSHSRSSRKHRDRRDRHRSKSRDSSSRGDKSVTIQAPGEPLLDAEST RGDDRDDNWGETTTVVTGTSEHSVSNEDLTRASKELEDSSPLECRRFAGPIVSGVLGLFA LLTPLAFLLLPQLLWRDSLEPCGTPCEGLYVSLAFKLLVLLISSWALFLRPSRSTLPRFF VFRCLLMALVFLFVASYWLFYGVRVLEPRERDYRGIVGYAVSLVDALLFIQYLALVLLEV RHLRPAFCLKVVRTTDGASRFYNVGHLSIQRAAVWVLDHYYTDFPVYNPALLNLPKSILS KKMSGFKVYSLGEENSTNNSTGQSRAMIAAAARRRDNSHNEYYYEEAEMDRRVRKRKARL VVAVEEAFTHIKRLQDDEAAASPKHPREVMDPREAAQAIFAPMARAMQKYLRTTRQQPYH SMESIISHLQFCITHNMTPKAFLERYLTPGPTMQYQRENGRGRQWTLVSEEPVTAALRQG LVFSLRRLDFALVVTVTPLPFLNLGEEFIDPKSHKFVMRLQSETSV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural progenitor cell morphogenesis, segregation of somites and adaxial cell development. Together with prickle1, required for the posterior (caudal) movement of branchiomotor neurons in the hindbrain independently of, and a few hours after, convergent extension. May be required for cell surface localization of fzd3 and fzd6 in the inner ear.
  • 基因功能參考文獻:
    1. Results demonstrate that anterior guidance decisions by commissural primary ascending (CoPA) axons are dependent on the function of planar cell polarity genes Fzd3a, Vangl2 and Scribble both prior to and after midline crossing; experiments establish CoPA axons as a model system to investigate the mechanism of planar cell polarity signaling in commissural axon guidance. PMID: 27955617
    2. dynamic Vangl2 intracellular distribution is coordinated with and necessary for the changes in convergence and extension cell behaviors during gastrulation PMID: 26062934
    3. we found that the critical period for Vangl2 function coincides with the initial stages of FBM neuron migration out of rhombomere 4. PMID: 24333599
    4. Vangl2 regulates FBM neuron migration by acting in floor plate cells, independently of cilia function PMID: 23988578
    5. VANGL2 regulates the endocytosis and cell-surface availability of MMP14 in a manner that is dependent on focal adhesion kinase. PMID: 22357946
    6. Vangl2(R259L) behaved like the wild-type allele in overexpression and morpholino knockdown/rescue assays in zebrafish embryos. PMID: 21404367
    7. data suggest that bbs8 and vangl2 act synergistically on cell polarization to establish and maintain the appropriate length and number of cilia in the Kupffer's vesicle and thereby facilitate correct LR asymmetry PMID: 20643117
    8. Vangl2 is required for asymmetric localization and posterior tilting of primary motile cilia at the apical membrane of epithelial cells. PMID: 20305649
    9. show that anterior hindbrain (r2/r3) motor neuron migration appears to be independent of vangl2 and pk1b functions, and suggest that multiple mechanisms regulate motor neuron migration along the anterior-posterior axis of the zebrafish hindbrain PMID: 19937772
    10. The vangl2 gene product mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis. PMID: 12105418

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Vang family
  • 組織特異性:
    Ubiquitously expressed at the 4-cell stage. In early somitogenesis, becomes more abundant in anterior neural tissue where expression is seen in the neural tube but not in the notochord.
  • 數據庫鏈接:


主站蜘蛛池模板: 青青国产揄拍视频| 亚洲夜夜性无码| 国产精品186在线观看在线播放| 国产伦久视频免费观看视频| 一本精品中文字幕在线| 亚洲另类无码专区国内精品| 天天狠天天透天干天天| 亚洲高清国产拍精品闺蜜合租| 国产欧美日韩综合精品一区二区| www国产内插视频| 免费现黄频在线观看国产| 99久久国产综合精品五月天喷水| 久久久日韩精品一区二区| 伊人情人色综合网站| 国产午睡沙发被弄醒完整版| 日日噜狠狠噜天天噜av| 男人扒女人添高潮视频| 亚洲中文字幕永久在线不卡| av国産精品毛片一区二区视频| 人人妻人人澡av| 人妻教师痴汉电车波多野结衣| 中文字幕人妻av一区二区| 国产新婚夫妇叫床声不断| 无码人妻熟妇av又粗又大| 动漫精品专区一区二区三区不卡| 国产成+人欧美+综合在线观看| 美女视频黄频a美女大全| 国产suv精品一区二区883| 午夜无码性爽快影院6080| 日本二区三区欧美亚洲国| 国产98色在线 | 国产| 任你干视频精品播放| 日韩精品无码不卡无码| 色婷婷美国农夫综合激情亚洲| 亚洲aⅴ无码国精品中文字慕| 先锋影音人妻啪啪va资源网站| 亚洲成在人线在线播放无码| 国产精品美女www爽爽爽视频| 亚洲国产欧美在线看片一国产 | 免费无码又爽又刺激高潮的app| 无码少妇一区二区|