在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Bovine Lysosomal-associated transmembrane protein 4B (LAPTM4B)

  • 中文名稱:
    牛LAPTM4B重組蛋白
  • 貨號:
    CSB-CF765155BO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    LAPTM4B
  • Uniprot No.:
  • 別名:
    LAPTM4B; Lysosomal-associated transmembrane protein 4B
  • 種屬:
    Bos taurus (Bovine)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-226
  • 氨基酸序列
    MKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLILNAVVLLILLSALADPDHYHFSSSEL GGDFEFMDDANMCIAIAISVLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNTLVAV TVLVYPNSIQEYIRQLPPDFPYKDDIMSVNPTCLVLIILLFISIILAFKGYLISCVWNCY RYINGRNSSDVLVYVTSNDSTVLLPPYDDATVNSATKEPPPPYVSA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.
  • 基因功能參考文獻:
    1. This study reports for the first time that bovine LAPTM4B in granulosa cells is present in both unubiquinated and ubiquinated forms, and is differentially expressed in developing ovarian follicles PMID: 25881887
    2. LAPTM4B is differentially expressed at the mRNA and protein levels in different bovine tissues. The mRNA yields a 26.3 kDa protein that undergoes mono-ubiquitination resulting in a 31.5 kDa isoform. Immunohistochemical observations revealed that LAPTM4B expression was highly variable among tissues, and among similar and adjacent cell types. LAPTM4B may confer protection against the accumulation of metabolic byproducts. PMID: 25881887
  • 亞細胞定位:
    Endomembrane system; Multi-pass membrane protein. Late endosome membrane. Cell membrane. Cell projection. Lysosome membrane. Endosome membrane. Endosome, multivesicular body membrane. Endosome, multivesicular body lumen.
  • 蛋白家族:
    LAPTM4/LAPTM5 transporter family
  • 組織特異性:
    Strongly expressed in fetal ovary, testis, adrenal gland, liver and uterus, and weakly expressed in the spleen.
  • 數據庫鏈接:


主站蜘蛛池模板: 国产又色又爽又刺激在线观看| 九九线精品视频在线观看| 玩弄丰满少妇人妻视频| 色欲色香天天天综合vvv| 中文字幕日本人妻久久久免费| 亚洲国产精品一区二区第四页| 亚洲美女高清无水av| 国产免费不卡av在线播放| 波多野结衣一区二区三区av高清| 亚洲精品无码久久久久| а√天堂www在线а√天堂视频| 婷婷色婷婷开心五月四房播播久久 | 四虎国产精品永久地址入口| 手机国产乱子伦精品视频| 狠狠躁夜夜躁人人爽天天5| 无码免费一区二区三区免费播放| 国产色青青视频在线观看撒| 久久精品国产2020| 无码人妻aⅴ一区二区三区| 人妻系列无码专区久久五月天| 亚洲精品无码国产| 十八禁av无码免费网站| 伊人久久久精品区aaa片| 伊人久久大香线蕉avapp下载| 国产一卡2卡3卡4卡国色天香| 夜夜躁狠狠躁日日躁视频| 久久精品国产大片免费观看| 午夜性开放午夜性爽爽| 国产激情无码一区二区app| 无码日韩精品一区二区三区免费| 国产精品自产拍在线观看| 亚洲一区二区女搞男| 国产人妻久久精品二区三区| 国产微拍精品一区二区| 少妇久久久久久久久久| 在线视频精品免费观看10| 日韩精品亚洲人旧成在线| 国产精品一区二区高清在线| 亚裔大战黑人老外av| 人妻少妇乱子伦无码专区| 国产裸体xxxx视频在线播放|