在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Xenopus laevis Serine/threonine-protein kinase PLK1 (plk1)

  • 中文名稱:
    有爪蟾蜍plk1重組蛋白
  • 貨號:
    CSB-YP018193XBE
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    有爪蟾蜍plk1重組蛋白
  • 貨號:
    CSB-EP018193XBE
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    有爪蟾蜍plk1重組蛋白
  • 貨號:
    CSB-EP018193XBE-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    有爪蟾蜍plk1重組蛋白
  • 貨號:
    CSB-BP018193XBE
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    有爪蟾蜍plk1重組蛋白
  • 貨號:
    CSB-MP018193XBE
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    plk1; plx1; Serine/threonine-protein kinase PLK1; EC 2.7.11.21; Plx1; Polo-like kinase 1; PLK-1
  • 種屬:
    Xenopus laevis (African clawed frog)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates cdc25, pkmyt1/myt1, stag2/sa2, tpx2. Plays multiple essential roles during mitosis. Phosphorylates the N-terminal domain of cdc25, which leads to cyclin b-cdc2 activation and mitotic entry. Also required for organization of bipolar spindles, and for exit from mitosis. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating stag2/sa2.
  • 基因功能參考文獻:
    1. Novel roles for Plk and GSK3 regulation of ADAM13 function in cranial neural crest cell migration. PMID: 25298404
    2. Plx1-mediated degradation of Bora in interphase generates oscillations in Plx1 activity and is essential for development. PMID: 24675888
    3. Coordinated interplays between Plx1 and Gwl are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery. PMID: 21708943
    4. the penultimate CRS serine (Ser 101) of cyclin b1 is a Plx substrate PMID: 12612056
    5. Results suggest that polo-like kinase (Plx1) could be the missing regulator that prevents maturation-promoting factor autoamplification in stage IV oocytes. PMID: 14985258
    6. Plx1 cooperates with CaMKII to regulate cyclosome regulators, and is necessary for release of cytostatic factor metaphase arrest and sufficient when overexpressed. PMID: 16040245
    7. Data show that Plx1 couples tension signals to cellular responses through phosphorylation of the 3F3/2 epitope and targeting structural and checkpoint proteins to kinetochores. PMID: 16129782
    8. Polo-like kinase Plx1 is an essential factor for calcium ion-induced meiotic exit during cytostatic factor arrest PMID: 16407128
    9. Polo-like kinase (Plx1) phosphorylates xTRF1 in vitro and the mitotic xTRF1-chromatin association was significantly impaired when Plx1 was immunodepleted from the extracts (Plx1). PMID: 16424898
    10. Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and plk-mediated formation of the 3F3/2 epitope. PMID: 17998400
    11. Plx1 promotes activation of Aurora A, most likely through TPX2. PMID: 19556869

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody.
  • 蛋白家族:
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 數(shù)據(jù)庫鏈接:

    KEGG: xla:380481

    UniGene: Xl.28141



主站蜘蛛池模板: 欧美成人家庭影院| 少妇大叫好爽受不了午夜视频 | 国产精品毛片av在线看| 久久这里只有精品首页| 娇妻玩4p被三个男人伺候电影 | 丁香五月欧美成人| 毛色毛片免费观看| 熟妇玩小男视频在线| 4480yy私人精品国产| 国内精品2020情侣视频| 精品国产品香蕉在线| 欧美又大又硬又粗bbbbb| 亚州少妇无套内射激情视频| 夜色约爱网站| 国产av国片精品一区二区| 四虎成人精品永久网站| 最新av偷拍av偷窥av网站| 男女下面进入的视频| 国产99青草视频在线播放视| 男女做爰无遮挡性视频| 久久亚洲精品中文字幕无码| 精品国产sm最大网免费站| 亚洲欧美韩国综合色| 亚洲中文字幕无码av正片| 欧洲精品成人免费视频在线观看| 99久久国产热无码精品免费| 日产精品卡二卡三卡四卡乱码视频| 国产成人av在线播放影院| 国产亚洲综合久久系列| 亚洲 欧美 激情 小说 另类| 国产婷婷色一区二区三区在线| 国产一区二区三区在线视頻| 麻豆国产成人av高清在线| 国产精品久久国产精品99 gif| 免费观看的av在线播放| 久久亚洲精品无码av宋| 亚洲va在线∨a天堂va欧美va| 久久99精品久久久久婷婷| 成年片色大黄全免费软件到| 久久久99精品成人片| 精品国产品香蕉在线|