在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Vipera ammodytes ammodytes Phospholipase A2, ammodytoxin B (ATXB)

  • 中文名稱:
    Recombinant Vipera ammodytes ammodytes Phospholipase A2, ammodytoxin B(ATXB)
  • 貨號:
    CSB-YP319699VFO
  • 說明書:
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Vipera ammodytes ammodytes Phospholipase A2, ammodytoxin B(ATXB)
  • 貨號:
    CSB-EP319699VFO
  • 說明書:
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Vipera ammodytes ammodytes Phospholipase A2, ammodytoxin B(ATXB)
  • 貨號:
    CSB-EP319699VFO-B
  • 說明書:
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Vipera ammodytes ammodytes Phospholipase A2, ammodytoxin B(ATXB)
  • 貨號:
    CSB-BP319699VFO
  • 說明書:
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Vipera ammodytes ammodytes Phospholipase A2, ammodytoxin B(ATXB)
  • 貨號:
    CSB-MP319699VFO
  • 說明書:
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    N/A
  • Uniprot No.:
  • 別名:
    Basic phospholipase A2 ammodytoxin B; AtxB; svPLA2; EC 3.1.1.4; Phosphatidylcholine 2-acylhydrolase
  • 種屬:
    Vipera ammodytes ammodytes (Western sand viper)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區(qū)域:
    17-138
  • 氨基酸序列
    SLLE FGMMILGETG KNPLTSYSFY GCYCGVGGKG TPKDATDRCC FVHDCCYGNL PDCSPKTDRY KYHRENGAIV CGKGTSCENR ICECDRAAAI CFRKNLKTYN HIYMYYPDFL CKKESEKC
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Snake venom phospholipase A2 (PLA2) that acts as a presynaptic neurotoxin, an inhibitor of blood coagulation, and has been found to bind with high affinity to intracellular proteins. The response of indirectly stimulated neuromuscular preparations to ammodytoxin (Atx) is triphasic. The first phase, the transient inhibition of the acetylcholine (ACh) release, starts soon after the addition of Atx and lasts for several minutes. This phase is probably independent of Atx enzymatic activity. The effect may be due to the specific binding of the toxin to presynaptic receptors. These receptors, called N-type receptors, are still unidentified. It is noteworthy that a neuronal isoform of the M-type PLA2 receptor (R180) has been identified as a high-affinity receptor for Atx in neuronal plasma membranes. It was demonstrated however that this receptor is not essential for expression of neurotoxicity by Atx. The second phase corresponds to an augmentation of neurotransmitter release. A peak is reached 10-20 min after exposure of the preparation to Atx and is followed by a gradual reduction. In this phase, the enzymatic activity of Atx of the mammalian is not significant. It is speculated that the increased release of neurotransmitter in this phase is induced by the interference of Atx with voltage-gated potassium channels. Measurements of ionic currents showed however that voltage-gated potassium channels are not affected by Atx. The third phase of the response of neuromuscular preparations to Atx, which corresponds to a complete and irreversible paralysis, is clearly dependent on the hydrolytic activity of the toxin. In addition to its presynaptic neurotoxicity, Atx shows an anticoagulant activity by binding with high affinity to activated coagulation factor X (F10) thus inhibiting the formation of the prothrombinase complex (FX/FV) and its activity (IC(50) is 82 nM). Surprisingly, Atx was discovered to bind intracellular proteins such as calmodulin (CaM), 14-3-3 proteins gamma (YWHAG) and epsilon (YWHAE) (by similarity with AtxC), as well as R25 (by similarity with AtxC), a mitochondrial integral membrane protein found in cerebral cortex. These findings raised a doubt about the dogma of the exclusively extracellular action of PLA2s, defended by the potential instability of these molecules in the reducing environment of the eukaryotic cytosol coupled with their possible inability to act as enzymes in this cellular compartment, due to too low concentration of calcium ions. This hypothesis was challenged efficiently by demonstrating the internalization of AtxA into a culture cells, but still remains to be directly demonstrated in vivo. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
  • 亞細胞定位:
    Secreted. Host cytoplasm, host cytosol.
  • 蛋白家族:
    Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
  • 組織特異性:
    Expressed by the venom gland.


主站蜘蛛池模板: 精品国产第一福利网站| 亚洲欧美日韩综合久久久| 亚洲美女精品免费视频| 让少妇高潮无乱码高清在线观看| 中文字幕有码无码av| 国产高清在线精品一区| 性荡视频播放在线视频| 久久人人97超碰超国产| 亚洲欧美日韩综合久久久久久| 成人天堂资源www在线| 国产95在线 | 欧美| 国产在不卡免费一区二区三| 在线观看无码av免费不卡软件| 国产精品一线二线三线| 亚洲综合av色婷婷| 天堂网在线www资源| 欧美三级a做爰在线观看| 狠狠色噜噜狠狠狠狠777米奇| 久久精品日日躁夜夜躁欧美| 国产精品第一区揄拍无码| 免费做a爰片久久毛片a片| 狠狠躁日日躁夜夜躁2022麻豆| 国产在线午夜不卡精品影院| 中国白嫩丰满人妻videos| 国产伦孑沙发午休精品| 国产av麻豆mag剧集| 手机看黄av免费网址| 2020精品国产a不卡片| 夜夜夜夜曰天天天天拍国产| 亚洲精品国产成人一区二区| 欧美日产欧美日产国产精品| 2022国产成人精品视频人 | 亚洲а∨精品天堂在线| 精品国产乱码久久久久久1区2区| 中文人妻av久久人妻水密桃| 国产精品毛片更新无码| 黑人巨大精品欧美| 婷婷色婷婷开心五月| 国内精品自线在拍2020不卡| 人人爽天天碰天天躁夜夜躁| 天堂网www中文在线|