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  4. Recombinant Sheep Follicle-stimulating hormone receptor (FSHR), partial

Recombinant Sheep Follicle-stimulating hormone receptor (FSHR), partial

  • 中文名稱：
    綿羊FSHR重組蛋白
  • 貨號：
    CSB-YP009021SH1
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    綿羊FSHR重組蛋白
  • 貨號：
    CSB-EP009021SH1
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    綿羊FSHR重組蛋白
  • 貨號：
    CSB-EP009021SH1-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    綿羊FSHR重組蛋白
  • 貨號：
    CSB-BP009021SH1
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    綿羊FSHR重組蛋白
  • 貨號：
    CSB-MP009021SH1
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    FSHR; Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor
  • 種屬：
    Ovis aries (Sheep)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    G protein-coupled receptor for follitropin, the follicle-stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase. Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase. Isoform FSH-R3 may be involved in calcium signaling. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
  • 基因功能參考文獻：
    1. BB mutation-induced attenuation of BMPR1B signaling led to an increased density of the FSH receptor and LH receptor and a concurrent reduction in apoptosis PMID: 25948249
    2. Combined effect analyses indicated an extremely significant interaction between the random combinations of BMPR-IB, BMP-15 and FSHR genes on litter size. PMID: 25993301
    3. molecular cloning and characterization results identified a synonymous mutation in the ovine FSHR gene to be significantly associated with the litter size. PMID: 25103022
    4. Single nucleotide polymorphisms of 5' regulatory region of follicle-stimulating hormone receptor (FSHR) gene were detected in two high prolificacy sheep breeds and two low prolificacy sheep breeds. PMID: 21725846
  • 亞細胞定位：
    [Isoform FSH-R1]: Cell membrane; Multi-pass membrane protein.; [Isoform FSH-R2]: Cell membrane; Multi-pass membrane protein.; [Isoform FSH-R3]: Cell membrane; Single-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
  • 組織特異性：
    Isoform FSH-R3 is expressed in ovary and testis, but not in kidney (at protein level).
  • 數據庫鏈接：

    KEGG: oas:443299

    UniGene: Oar.372



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