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  4. Recombinant Schizosaccharomyces pombe Telomere length regulator taz1 (taz1), partial

Recombinant Schizosaccharomyces pombe Telomere length regulator taz1 (taz1), partial

  • 中文名稱：
    龐貝裂殖酵母taz1重組蛋白
  • 貨號：
    CSB-YP301278SXV
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    龐貝裂殖酵母taz1重組蛋白
  • 貨號：
    CSB-EP301278SXV
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    龐貝裂殖酵母taz1重組蛋白
  • 貨號：
    CSB-EP301278SXV-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    龐貝裂殖酵母taz1重組蛋白
  • 貨號：
    CSB-BP301278SXV
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    龐貝裂殖酵母taz1重組蛋白
  • 貨號：
    CSB-MP301278SXV
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    taz1
  • Uniprot No.：
  • 別名：
    taz1; myb; myb1; SPAC16A10.07c; Telomere length regulator taz1
  • 種屬：
    Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulates telomere length and function. Required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere-replicating enzyme, telomerase, or may protect against activation of telomerase-independent pathways of telomere elongation. It may be involved in the interactions between chromosomes and spindle proteins, disruption of these interactions would lead to defective meiosis.
  • 基因功能參考文獻：
    1. Taz1-Shelterin promotes facultative heterochromatin assembly at chromosome-internal sites containing late replication origins. PMID: 27264871
    2. Centromere detachment required telomere clustering-dependent spindle pole body recruitment of Taz1 and microtubules. PMID: 27611693
    3. Data indicate the differences in requirements of DNA-binding protein Teb1p and telomere-binding protein Taz1p for DNA binding PMID: 27101289
    4. telomere-binding protein Taz1 plays a crucial role in the control of replication timing in fission yeast PMID: 22987637
    5. Taz1 is required for cell-cycle restriction of telomerase activity PMID: 22633956
    6. the truncation of Taz1 protein is based on structural properties of taz1(+) mRNA. PMID: 20074552
    7. Taz1 binds to the telomere at the 3' overhang, then extrudes a loop that grows in size as the donut slides along the duplex DNA PMID: 15383525
    8. Taz1 can function independently of its known binding partners to maintain telomeres PMID: 16096639
    9. Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres. PMID: 16243027
    10. loss of Taz1 leads to stalled replication forks at telomeres and internally placed telomere sequences, regardless of whether the telomeric G-rich strand is replicated by leading- or lagging-strand synthesis PMID: 16598261

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Chromosome, telomere.
  • 數據庫鏈接：


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