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  4. Recombinant Saccharomyces cerevisiae Telomere length regulation protein ELG1 (ELG1), partial

Recombinant Saccharomyces cerevisiae Telomere length regulation protein ELG1 (ELG1), partial

  • 中文名稱：
    釀酒酵母ELG1重組蛋白
  • 貨號：
    CSB-YP606288SVG
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母ELG1重組蛋白
  • 貨號：
    CSB-EP606288SVG
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母ELG1重組蛋白
  • 貨號：
    CSB-EP606288SVG-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母ELG1重組蛋白
  • 貨號：
    CSB-BP606288SVG
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母ELG1重組蛋白
  • 貨號：
    CSB-MP606288SVG
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ELG1
  • Uniprot No.：
  • 別名：
    ELG1; RTT110; YOR144C; O3510; YOR3510CTelomere length regulation protein ELG1; Regulator of Ty1 transposition protein 110; Telomere elongation suppressor ELG1
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway. May have a role in Okazaki fragment maturation. Required for S-phase progression. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair.
  • 基因功能參考文獻(xiàn)：
    1. ELG1 deletion from pds5-1 mutant cells results in a significant rescue of chromatid cohesion, but not condensation, defects PMID: 25986377
    2. A high copy number suppressor screen was performed to search for genes that, when overexpressed, suppress the synthetic lethality between elg1Delta and srs2Delta mutants. PMID: 23704284
    3. Elg1 physically contacts the Mhf1/Mhf2 histone-like complex and genetically interacts with MPH1 (ortholog of the FANCM helicase) and CHL1 (ortholog of the FANCJ helicase) genes. PMID: 23624835
    4. Elg1 binds proteins that interact with SUMO. PMID: 21869594
    5. elg1-deficient Saccharomyces cerevisiae mutants have increased genome instability and telomere length regulated by S-phase checkpoints PMID: 15590829
    6. Elg1 function is required for maintaining genome stability during normal growth, and its absence has severe genetic consequences. PMID: 15725622
    7. Results suggest that Elg1 is involved in double strand break repair repair by homologous recombination. PMID: 17170004
    8. demonstrated that the N-terminus of Elg1 contributes to the maintenance of genome stability, and that one function of this N-terminus is to promote the nuclear localization of Elg1 PMID: 18482875
    9. Results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring. PMID: 19430531

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  • 亞細(xì)胞定位：
    Nucleus. Chromosome, telomere.
  • 蛋白家族：
    ELG1 family
  • 數(shù)據(jù)庫鏈接：

    KEGG: sce:YOR144C

    STRING: 4932.YOR144C



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