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  4. Recombinant Saccharomyces cerevisiae Phosphatidic acid phosphohydrolase 1 (PAH1), partial

Recombinant Saccharomyces cerevisiae Phosphatidic acid phosphohydrolase 1 (PAH1), partial

  • 中文名稱：
    釀酒酵母PAH1重組蛋白
  • 貨號：
    CSB-YP333712SVG
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母PAH1重組蛋白
  • 貨號：
    CSB-EP333712SVG
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母PAH1重組蛋白
  • 貨號：
    CSB-EP333712SVG-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母PAH1重組蛋白
  • 貨號：
    CSB-BP333712SVG
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母PAH1重組蛋白
  • 貨號：
    CSB-MP333712SVG
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PAH1
  • Uniprot No.：
  • 別名：
    PAH1; PAP1; SMP2; YMR165C; YM8520.14CPhosphatidic acid phosphohydrolase 1; PAP1; EC 3.1.3.4; Protein SMP2
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. Required for de novo lipid synthesis and formation of lipid droplets. Controles transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. Involved in plasmid maintenance, in respiration and in cell proliferation.
  • 基因功能參考文獻：
    1. Site-specific mutational analyses of the conserved residues within WRDPLVDID indicated that Trp-637 plays a crucial role in Pah1 function. This work also demonstrated that the catalytic activity of Pah1 is required but is not sufficient for its in vivo functions PMID: 29066621
    2. These results suggest that Pah1p plays an important role in vacuolar activity by negatively regulating the expression of V-ATPase genes. As such, we provide evidence to show the role of Pah1p in vacuolar acidification and fragmentation. PMID: 28756231
    3. The expression of Pah1 with combined mutations of S705D and 7A, which mimic its phosphorylation by CKII and lack of phosphorylation by Pho85-Pho80, caused an increase in triacylglycerol content and lipid droplet number in cells expressing the Nem1-Spo7 phosphatase complex. PMID: 27044741
    4. shortened chronological life span of the pah1Delta mutant along with its growth defect on non-fermentable carbon sources and hypersensitivity to hydrogen peroxide was suppressed by the loss of Dgk1 diacylglycerol kinase PMID: 26338708
    5. proteolysis of Pah1 by the 20S proteasome is controlled by its phosphorylation state PMID: 25809482
    6. Report functional conservation of PAP1 between yeast and human. PMID: 25475986
    7. essential role of PAH1 in triacylglycerol synthesis throughout growth PMID: 24196957
    8. Phosphorylation/dephosphorylation is a major mechanism by which Pah1p PAP activity is regulated. (Review) PMID: 22910056
    9. Pah1p and PA phosphatase activity are critical for vacuole homeostasis and fusion. PMID: 22121197
    10. the expression of PAH1-encoded phosphatidate phosphatase was induced by zinc deficiency. PMID: 22128164
    11. Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast PMID: 21708942
    12. Data suggest that diacylglycerol generated by Pah1p is important for lipid droplet biogenesis. PMID: 21422231
    13. Dephosphorylation of Pah1p by the Nem1p-Spo7p complex enables the amphipathic helix to anchor Pah1p onto the nuclear/ER membrane allowing the production of diacylglycerol for lipid biosynthesis. PMID: 20876142
    14. Smp2 associates with the promoters of phospholipid biosynthetic enzymes in a Nem1-Spo7-dependent manner. Smp2 is a critical factor in coordinating phospholipid biosynthesis at the nuclear/ER membrane with nuclear growth during the cell cycle. PMID: 15889145
    15. reports for the first time the identification of the S. cerevisiae PAH1 (previously known as SMP2) gene encoding a Mg2+-dependent PA phosphatase enzyme PMID: 16467296
    16. PAP1 activity of the PAH1 gene product is essential for its roles in lipid metabolism and cell physiology. PMID: 17971454

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  • 亞細胞定位：
    Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    Lipin family
  • 數據庫鏈接：

    KEGG: sce:YMR165C

    STRING: 4932.YMR165C



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