在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PAH1 Antibody

Rare Species
  • 中文名稱:
    PAH1 Antibody
  • 貨號:
    CSB-PA333712XA01SVG
  • 規格:
    ¥880
  • 圖片:
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:PAH1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 30.4 kDa
      Observed band size: 30 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PAH1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PAH1
  • 別名:
    Phosphatidic acid phosphohydrolase 1 (PAP1) (EC 3.1.3.4) (Protein SMP2) PAH1 PAP1 SMP2 YMR165C YM8520.14C
  • 宿主:
    Rabbit
  • 反應種屬:
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 免疫原:
    Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PAH1 protein (350-583aa)
  • 免疫原種屬:
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. Required for de novo lipid synthesis and formation of lipid droplets. Controles transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. Involved in plasmid maintenance, in respiration and in cell proliferation.
  • 基因功能參考文獻:
    1. Site-specific mutational analyses of the conserved residues within WRDPLVDID indicated that Trp-637 plays a crucial role in Pah1 function. This work also demonstrated that the catalytic activity of Pah1 is required but is not sufficient for its in vivo functions PMID: 29066621
    2. These results suggest that Pah1p plays an important role in vacuolar activity by negatively regulating the expression of V-ATPase genes. As such, we provide evidence to show the role of Pah1p in vacuolar acidification and fragmentation. PMID: 28756231
    3. The expression of Pah1 with combined mutations of S705D and 7A, which mimic its phosphorylation by CKII and lack of phosphorylation by Pho85-Pho80, caused an increase in triacylglycerol content and lipid droplet number in cells expressing the Nem1-Spo7 phosphatase complex. PMID: 27044741
    4. shortened chronological life span of the pah1Delta mutant along with its growth defect on non-fermentable carbon sources and hypersensitivity to hydrogen peroxide was suppressed by the loss of Dgk1 diacylglycerol kinase PMID: 26338708
    5. proteolysis of Pah1 by the 20S proteasome is controlled by its phosphorylation state PMID: 25809482
    6. Report functional conservation of PAP1 between yeast and human. PMID: 25475986
    7. essential role of PAH1 in triacylglycerol synthesis throughout growth PMID: 24196957
    8. Phosphorylation/dephosphorylation is a major mechanism by which Pah1p PAP activity is regulated. (Review) PMID: 22910056
    9. Pah1p and PA phosphatase activity are critical for vacuole homeostasis and fusion. PMID: 22121197
    10. the expression of PAH1-encoded phosphatidate phosphatase was induced by zinc deficiency. PMID: 22128164
    11. Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast PMID: 21708942
    12. Data suggest that diacylglycerol generated by Pah1p is important for lipid droplet biogenesis. PMID: 21422231
    13. Dephosphorylation of Pah1p by the Nem1p-Spo7p complex enables the amphipathic helix to anchor Pah1p onto the nuclear/ER membrane allowing the production of diacylglycerol for lipid biosynthesis. PMID: 20876142
    14. Smp2 associates with the promoters of phospholipid biosynthetic enzymes in a Nem1-Spo7-dependent manner. Smp2 is a critical factor in coordinating phospholipid biosynthesis at the nuclear/ER membrane with nuclear growth during the cell cycle. PMID: 15889145
    15. reports for the first time the identification of the S. cerevisiae PAH1 (previously known as SMP2) gene encoding a Mg2+-dependent PA phosphatase enzyme PMID: 16467296
    16. PAP1 activity of the PAH1 gene product is essential for its roles in lipid metabolism and cell physiology. PMID: 17971454

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族:
    Lipin family
  • 數據庫鏈接:

    KEGG: sce:YMR165C

    STRING: 4932.YMR165C



主站蜘蛛池模板: 亚洲gv天堂无码男同在线观看| 国产亚洲美女精品久久久| 国产成+人+综合+亚洲欧美丁香花| 欧美成人免费va影院高清| 韩国无码av片在线观看网站| 久久综合久色欧美综合狠狠| 乱子轮熟睡1区| 久久久久国产精品人妻aⅴ四季| 国产美女遭强高潮网站下载| 久久久久久久久无码精品亚洲日韩| 996久久国产精品线观看| 国产亚洲精品久久综合阿香| 国产午夜福利在线观看视频_ | 国产精华av午夜在线观看| 中国6一12呦女精品| 一区二区三区在线 | 网站| 激情偷乱人伦小说视频| 99国产欧美久久久精品| 久久久久99精品国产片| 男人用嘴添女人私密视频| 亚洲已满18点击进入在线观看 | 狠狠躁夜夜躁人人爽天天bl| 一本加勒比hezyo无码专区| 色 亚洲 日韩 国产 综合| 2020国产欧洲精品网站| 亚洲欧美日韩另类丝袜一区| 成人免费毛片aaaaaa片| 亚洲国产精品久久久久婷蜜芽| 日韩av无码一区二区三区不卡毛片| 夫妻免费无码v看片| 成av免费大片黄在线观看| 制服 丝袜 亚洲 中文 综合 | 怡红院av一区二区三区| 人妻少妇一区二区三区| 四虎永久在线精品免费观看视频| 亚洲人成日韩中文字幕无卡| 亚洲日韩国产成网在线观看| 中文字幕乱码人在线视频1区| 亚洲一区二区三区自拍天堂| 日日噜噜夜夜狠狠va视频v| 7878成人国产在线观看|