在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Saccharomyces cerevisiae Mitochondrial import inner membrane translocase subunit TIM23 (TIM23), partial

Recombinant Saccharomyces cerevisiae Mitochondrial import inner membrane translocase subunit TIM23 (TIM23), partial

  • 中文名稱：
    釀酒酵母TIM23重組蛋白
  • 貨號：
    CSB-YP023553SVG1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母TIM23重組蛋白
  • 貨號：
    CSB-EP023553SVG1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母TIM23重組蛋白
  • 貨號：
    CSB-EP023553SVG1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母TIM23重組蛋白
  • 貨號：
    CSB-BP023553SVG1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母TIM23重組蛋白
  • 貨號：
    CSB-MP023553SVG1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TIM23
  • Uniprot No.：
  • 別名：
    TIM23; MAS6; MIM23; MPI3; YNR017W; N3180; Mitochondrial import inner membrane translocase subunit TIM23; Membrane import machinery protein MIM23; Mitochondrial protein import protein 3; Mitochondrial protein import protein MAS6
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
  • 基因功能參考文獻：
    1. Cation selectivity of Tim23 is crucial for efficient protein import. PMID: 28857742
    2. reduced phosphatidylcholine levels differentially affect the TIM22 and TIM23 complexes in mitochondrial protein transport PMID: 27402832
    3. Tim23 contains multiple sites to interact with the intermembrane space domain of Tim21 and to bind to Tim21, Tim50, and Tom22.A central role of the intermembrane space domain of Tim23 in the formation and regulation of the presequence translocase. PMID: 25263020
    4. Modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM23 complex, proves therapeutic in both yeast and patient-derived cells exhibiting ATP synthase deficiency. PMID: 25519239
    5. The GxxxG motifs found in the first and second transmembrane segments of Tim23 are necessary for the structural integrity of the TIM23 complex. PMID: 25765297
    6. IMS domain of Tim23 tightly associates with both inner and outer mitochondrial membrane-like membranes through a hydrophobic anchor at its N terminus PMID: 25349212
    7. Data propose that Mgr2 functions at the checkpoint for lateral sorting of the TIM23 complex in mitochondria. PMID: 25454944
    8. the mitochondrial ADP/ATP carrier associates with the membrane-embedded core of the TIM23 complex in a stoichiometric manner PMID: 25124039
    9. TIM23 transmembrane helix 2 is involved in the recruitment of Tim21 and the presequence-associated motor (PAM) subcomplex to the Tim23 channel. PMID: 24061477
    10. Changes in the energized state of the mitochondrial inner membrane cause marked structural alterations in the Tim23 channel region. PMID: 23832274
    11. analysis of the threshold hydrophobicity for TIM23-mediated insertion in the inner mitochondrial membrane PMID: 23283966
    12. analyses have revealed a novel transport mechanism for a polytopic membrane protein in which internal signals direct the precursor into the inner membrane via the TIM23 complex, indicating a presequence-independent function of this translocase PMID: 23045398
    13. analysis of interaction of mitochondrial targeting presequences with purified components of the TIM23 protein complex PMID: 21969381
    14. The beta-hairpin is crucial for the interaction of Tim50 with Tim23, suggesting a cooperative function of these two essential TIM proteins in preprotein import. PMID: 21704637
    15. The authors find that hydrophobicity and the location of polar and aromatic residues are strong determinants of membrane insertion mediated by TIM23. PMID: 21326212
    16. By using NMR spectroscopy, we show that Tim23N is a monomeric protein belonging to the family of intrinsically disordered proteins. Titrations of Tim23N with two presequences revealed a distinct binding region of Tim23N formed by residues 71-84. PMID: 20718036
    17. Tim23p acts as receptor for preproteins and may largely constitute the preprotein-conducting passageway of preprotein translocase. PMID: 17148445
    18. Study showed that the protein transport in mutant TIM23 mitochondria was strongly impaired. PMID: 17828250
    19. These structural changes reveal that the macromolecular arrangement within the TIM23 complex is dynamic and varies with the physiological state of the mitochondrion. PMID: 17959826
    20. TIM23 complex acts as a single structural and functional entity that is actively remodelled to sort preproteins into different mitochondrial subcompartments. PMID: 18418384
    21. Probes on the aqueous-facing helical surface of TIM23 specifically underwent spectral changes during protein import. PMID: 18692467
    22. Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex. PMID: 19017642

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein. Note=Around 20 amino acids of the N-terminus are believed to span the mitochondrial outer membrane. This association is dynamic and depends on the translocation activity of the TIM23 complex. However, this topology seems not to be critical for formation of a TOM-TIM supercomplex and preprotein import.
  • 蛋白家族：
    Tim17/Tim22/Tim23 family
  • 數據庫鏈接：

    KEGG: sce:YNR017W

    STRING: 4932.YNR017W



主站蜘蛛池模板： 国产va免费精品高清在线| 亚洲 欧美 日韩 国产综合 在线| 少妇一边呻吟一边说使劲视频| 久久亚洲国产精品成人av秋霞| 免费国产h视频在线观看| 亚洲超碰无码色中文字幕97| 999久久久免费精品国产| 乌克兰少妇性做爰| 日本丰满熟妇videossex| 国产乱子伦一区二区三区视频播放| 国产情侣一区二区| 亚洲精品久久久久久一区二区| 久久亚洲精品国产精品777777| 亚洲欧洲久久av| 久爱www成人网免费视频| 成年无码av片在线| 无码国模产在线观看免费| 亚洲s久久久久一区二区| 18禁免费无码无遮挡不卡网站| 男人用嘴添女人私密视频| 女性自慰网站免费观看w| 日本无码人妻一区二区色欲| 国内精品伊人久久久久影院麻豆| 久久精品国产亚洲a片高清不卡| 天堂网www天堂资源网| 亚洲欧美成aⅴ人在线观看| 日韩超碰人人爽人人做人人添| 99精品热这里只有精品| 日韩亚洲国产高清免费视频| 全免费又大粗又黄又爽少妇片| 欧美高清性色生活片免费观看 | 成熟丰满熟妇高潮xxxxx视频| 国产白嫩护士在线播放| av无码不卡一区二区三区| 日本免费一区二区三区中文字幕 | 日本看片一二三区高清| 国产又粗又硬又大爽黄老大爷| 国产麻花豆剧传媒精品mv在线 | 老头把我添高潮了a片| 日韩成人一区二区三区在线观看 | 久久国产av影片|