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  4. Recombinant Saccharomyces cerevisiae General transcriptional corepressor TUP1 (TUP1), partial

Recombinant Saccharomyces cerevisiae General transcriptional corepressor TUP1 (TUP1), partial

  • 中文名稱：
    釀酒酵母TUP1重組蛋白
  • 貨號：
    CSB-YP322303SVG
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母TUP1重組蛋白
  • 貨號：
    CSB-EP322303SVG
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母TUP1重組蛋白
  • 貨號：
    CSB-EP322303SVG-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母TUP1重組蛋白
  • 貨號：
    CSB-BP322303SVG
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母TUP1重組蛋白
  • 貨號：
    CSB-MP322303SVG
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TUP1
  • Uniprot No.：
  • 別名：
    TUP1; AAR1; AER2; AMM1; CYC9; FLK1; SFL2; UMR7; YCR084C; YCR84C; General transcriptional corepressor TUP1; Flocculation suppressor protein; Glucose repression regulatory protein TUP1; Repressor AER2
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
  • 基因功能參考文獻：
    1. Tup1 regulates GAL1 epigenetic transcriptional memory. Tup1 is necessary for incorporation of both H2A.Z and H3K4me2 at the GAL1 promoter. PMID: 28607146
    2. we identified a transposable element insertion in the promoter region of known flocculation gene FLO1, and, in an additional five clones, we recovered loss-of-function mutations in transcriptional repressor TUP1, which regulates FLO1 and other related genes PMID: 28450459
    3. CYC8 and TUP1 were required for transcription of the amino acid transporter genes. PMID: 26546823
    4. coordinated sumoylation of Gcn4, Tup1 and likely other factors dampens activated transcription by stabilizing Tup1 binding and stimulating Gcn4 and RNAP II removal PMID: 25766875
    5. These data suggest that distinctly bound Cyc8-Tup1 cooperates with Hda1p and Rpd3p to establish or maintain an extensive array of strongly positioned, deacetylated nucleosomes over the FLO1 promoter and upstream region which inhibit histone acetylation, block Swi-Snf binding and prevent transcription. PMID: 25106892
    6. Data indicate that Tup1 and the metabolic enzymes that control PI(3,5)P2 are highly conserved among eukaryotes. PMID: 23733183
    7. data presented herein highlight the importance of the architecture of the Tup1p N-terminal domain for self-association PMID: 22707714
    8. Cyc8-Tup1 regulates transcription primarily by masking and inhibiting the transcriptional activation domains of the recruiting proteins, not by acting as a corepressor PMID: 22156212
    9. Analysis of wild-type and tup1 Delta chromatin data sets revealed unique organizational themes relating to the function of Tup1. PMID: 21785133
    10. Tup1--which associates with multiple transcriptional regulators, including the HDAC (histone deacetylase) and SAGA complexes--plays a crucial role in determining an activated or repressed chromatin state of numerous genes, including GAL1. PMID: 21536737
    11. Ssn6-Tup1 requires ISW2 complex to position nucleosomes. PMID: 15116071
    12. Hda1 partially represses roughly 30% of Tup1-repressed genes, whereas Srb10 kinase activity contributes to the repression of approximately 15% of Tup1-repressed genes. PMID: 15240822
    13. A genome-wide analysis was made of the functions of a conserved surface on the corepressor TUP1. PMID: 15788561
    14. Transcription in the absence of heme required the presence of Cti6p to overcome the effect of Tup1p, and Cti6p was recruited to the ARN1 promoter in the absence of heme. PMID: 16437160
    15. Data show that Htz1 is required for efficient Mediator recruitment and transcription only when the GAL1 promoter is under the influence of the Tup1 corepressor. PMID: 17387147
    16. in the absence of Tup1, TPR1 is partially unfolded with its helix B being highly dynamic exposing an apolar surface to the solvent PMID: 17634984
    17. in Srb10p derivatives, the absence of CM-1 & CM-II motifs decreases the interaction of Srb10p with its cyclin partner Srb11p and with the component Tup1p of the general co-repressor complex Tup1p-Ssn6p. PMID: 17689156
    18. Chromatin immunoprecipitation analyses of the GRE2 promoter in the mutants demonstrated that the Sko1-Tup1-Cyc8 complex was localized to the promoter PMID: 18201562
    19. analysis of functional links between the amino acids-sensing SPS system, the CUP9-TUP1-SSN6 repressor complex, the PTR2 peptide transporter, and the UBR1-dependent N-end rule pathway PMID: 18708352

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat TUP1 family
  • 數據庫鏈接：

    KEGG: sce:YCR084C

    STRING: 4932.YCR084C



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