在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Saccharomyces cerevisiae Cysteine protease ATG4 (ATG4)

  • 中文名稱:
    Recombinant Saccharomyces cerevisiae Cysteine protease ATG4(ATG4)
  • 貨號(hào):
    CSB-YP345712SVG
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Saccharomyces cerevisiae Cysteine protease ATG4(ATG4)
  • 貨號(hào):
    CSB-EP345712SVG
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Saccharomyces cerevisiae Cysteine protease ATG4(ATG4)
  • 貨號(hào):
    CSB-EP345712SVG-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Saccharomyces cerevisiae Cysteine protease ATG4(ATG4)
  • 貨號(hào):
    CSB-BP345712SVG
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Saccharomyces cerevisiae Cysteine protease ATG4(ATG4)
  • 貨號(hào):
    CSB-MP345712SVG
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ATG4
  • Uniprot No.:
  • 別名:
    ATG4; APG4; AUT2; YNL223W; N1274Cysteine protease ATG4; EC 3.4.22.-; Autophagy-related protein 4
  • 種屬:
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-494
  • 氨基酸序列
    MQRWLQLWKM DLVQKVSHGV FEGSSEEPAA LMNHDYIVLG EVYPERDEES GAEQCEQDCR YRGEAVSDGF LSSLFGREIS SYTKEFLLDV QSRVNFTYRT RFVPIARAPD GPSPLSLNLL VRTNPISTIE DYIANPDCFN TDIGWGCMIR TGQSLLGNAL QILHLGRDFR VNGNESLERE SKFVNWFNDT PEAPFSLHNF VSAGTELSDK RPGEWFGPAA TARSIQSLIY GFPECGIDDC IVSVSSGDIY ENEVEKVFAE NPNSRILFLL GVKLGINAVN ESYRESICGI LSSTQSVGIA GGRPSSSLYF FGYQGNEFLH FDPHIPQPAV EDSFVESCHT SKFGKLQLSE MDPSMLIGIL IKGEKDWQQW KLEVAESAII NVLAKRMDDF DVSCSMDDVE SVSSNSMKKD ASNNENLGVL EGDYVDIGAI FPHTTNTEDV DEYDCFQDIH CKKQKIVVMG NTHTVNANLT DYEVEGVLVE KETVGIHSPI DEKC
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. Moreover not only conjugation, but also subsequent ATG8-PE deconjugation performed also by ATG4 is an important step required to delipidate ATG8 to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
  • 基因功能參考文獻(xiàn):
    1. findings showt Atg4 is recruited onto autophagosomal membranes by direct binding to Atg8 via two evolutionarily conserved Atg8 recognition sites; propose a model where Atg4 activity on autophagosomal membranes depends on cooperative action of at least 2 sites within Atg4, in which one functions as a constitutive Atg8 binding module, while the other has a preference toward phosphatidylethanolamine-bound Atg8 PMID: 28330855
    2. Results provide evidence that Atg4 plays an important role in efficient expansion of autophagic isolation membranes by cleaving lipidated Atg8 in Saccharomyces cerevisiae. PMID: 28704456
    3. fine-tuning of Atg4 activity depending on the intracellular redox state may regulate autophagosome formation PMID: 25483965
  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Peptidase C54 family
  • 數(shù)據(jù)庫(kù)鏈接:

    KEGG: sce:YNL223W

    STRING: 4932.YNL223W



主站蜘蛛池模板: 色两性网欧美| 丰满少妇大力进入| 久久综合狠狠综合久久激情| 国产裸拍裸体视频在线观看| 成人片黄网站a毛片免费| 青草影院内射中出高潮| 国产日韩在线视看高清视频手机 | 色一情一区二区三区四区| 久久精品农村毛片| 天堂在/线中文在线资源8| 亚洲va中文字幕无码久久不卡| 老色69久久九九精品高潮| 精品久久久久久成人av| 野外少妇被弄到喷水在线观看| 欧美成人性做爰77777| 女人被男人躁得好爽免费视频 | 欧美不卡高清一区二区三区 | 国产午夜福利片在线观看| 曰韩免费无码av一区二区| 色老头av亚洲一区二区男男| 香蕉在线依人视频| 国产成人精品一区二区三区无码 | 国产麻豆剧传媒精品国产av| 777精品久无码人妻蜜桃| 精品一区二区三区国产在线观看| 亚洲中文字幕无码乱线| 久久精品国产精品亚洲| 久久综合给合久久狠狠狠88 | 精品一卡二卡三卡四卡网站| 免费精品国产自在| 极品少妇xxxx精品少妇偷拍| 亚洲成在人线av无码| 亚洲精品久久av无码一区二区| 色一情一乱一乱一区99av白浆| 国精产品一区一区三区有限公司杨 | 亚洲国产成人精品无码区一本| 成人午夜福利视频镇东影视| 久久精品2021国产| 国产免费一区二区三区不卡| 欧美成人一区二区三区片免费| 亚洲精品国产精品乱码不99|