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  4. Recombinant Rat Urea transporter 2 (Slc14a2), partial

Recombinant Rat Urea transporter 2 (Slc14a2), partial

  • 中文名稱：
    大鼠Slc14a2重組蛋白
  • 貨號：
    CSB-YP714025RA
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Slc14a2重組蛋白
  • 貨號：
    CSB-EP714025RA
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Slc14a2重組蛋白
  • 貨號：
    CSB-EP714025RA-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Slc14a2重組蛋白
  • 貨號：
    CSB-BP714025RA
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Slc14a2重組蛋白
  • 貨號：
    CSB-MP714025RA
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc14a2
  • Uniprot No.：
  • 別名：
    Slc14a2; Ut2; Urea transporter 2; Solute carrier family 14 member 2; Urea transporter; kidney
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Vasopressin regulates urea transport by increasing isoform 1 accumulation in the plasma membrane and/or phosphorylation of isoform 1.
  • 基因功能參考文獻：
    1. Report thiourea analogs as inhibitors of UT-A mediated urea transport. PMID: 25613743
    2. Activation of cAMP/PKA increases 14-3-3gamma interactions with UT-A1 and stimulates MDM2-mediated UT-A1 ubiquitination and degradation, forming a novel regulatory mechanism of urea transport activity. PMID: 25995111
    3. UT-A1 localized to the apical membrane in response to vasopressin was phosphorylated at Ser(486) and Ser(499). PMID: 25377918
    4. The highly stable expression of highly glycosylated UT-A3 on the cell membrane in kidney inner medulla suggests that UT-A3 may have an important function in urea reabsorption. PMID: 22535801
    5. new role of N-linked glycosylation in regulating UT-A1 activity by promoting UT-A1 trafficking into membrane lipid raft subdomains PMID: 21965602
    6. Study concluded that UT-B1 mediates the transepithelial movement of urea that occurs in specific distal regions of the rat gastrointestinal tract. PMID: 21127847
    7. Suggest that responsiveness to vasopressin that observed with UT-A1 can be introduced into the unresponsive UT-A2 variant through the Lc segment that is unique to UT-A1. In UT-A3 the Lc segment plays no significant role in its activation by cAMP. PMID: 20457831
    8. This study confirmed that vasopressin increases UT-A1 accumulation in the apical plasma membrane and showed that vasopressin phosphorylates UT-A1 at S486 in rat IMCDs and that the phosphorylated form is primarily detected in the apical plasma membrane. PMID: 20071460
    9. Testing the hypothesis that an increase in urinary solutes but not urea would increase UT-A1 abundance, similar to diabetes mellitus. PMID: 15251864
    10. the 117-kDa UT-A1 glycoprotein is necessary for vasopressin-stimulated urea transport PMID: 15886274
    11. UT-A1 may be linked to the SNARE machinery via snapin and this interaction may be functionally and physiologically important for urea transport PMID: 17702749
    12. ubiquitination regulates the plasma membrane expression of all three major UT-A urea transporters, but that this is not the mechanism primarily used by vasopressin to produce its physiological effects. PMID: 18448630
    13. We conclude that the phosphorylation of UT-A1 on both serines 486 and 499 is important for activity and that this phosphorylation may be involved in UT-A1 membrane accumulation. PMID: 18495802
    14. The increase in the urea permeability due to hyperosmolarity reflects both UT-A1 and UT-A3 movement to the plasma membrane in the medullary collecting duct and may be a direct response to tonicity. The movement is accompanied by increased phosphorylation. PMID: 18715940
    15. MDM2 mediates UT-A1 ubiquitination both in vivo and in vitro. The ubiquitin-proteasome degradation pathway provides an important novel mechanism for UT-A1 regulation. PMID: 18784257
    16. In uremic rats, an urea transporter type UT-A2 was expressed in the pars recta, suggesting a possible relation with the fractional urea excretion increase. PMID: 19034881
    17. activation of Epac increases urea transport, accumulation of UT-A1 at the plasma membrane, and UT-A1 phosphorylation, the latter of which is mediated by the MEK-ERK pathway PMID: 19661162

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  • 亞細胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Urea transporter family
  • 組織特異性：
    Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney. Isoform 3 and isoform 4 are expressed in both the inner and outer renal medulla.
  • 數據庫鏈接：


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