在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Tyrosine-protein kinase CSK (Csk)

  • 中文名稱:
    Recombinant Rat Tyrosine-protein kinase CSK(Csk)
  • 貨號:
    CSB-YP006056RA
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Rat Tyrosine-protein kinase CSK(Csk)
  • 貨號:
    CSB-EP006056RA
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Rat Tyrosine-protein kinase CSK(Csk)
  • 貨號:
    CSB-EP006056RA-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Rat Tyrosine-protein kinase CSK(Csk)
  • 貨號:
    CSB-BP006056RA
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Rat Tyrosine-protein kinase CSK(Csk)
  • 貨號:
    CSB-MP006056RA
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Csk
  • Uniprot No.:
  • 別名:
    Csk; Tyrosine-protein kinase CSK; EC 2.7.10.2; C-Src kinase
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-450
  • 氨基酸序列
    SAIQASWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV SCEGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTTDA DGLCTRLIKP KVMEGTVAAQ DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYDVMK NCWHLDAATR PTFLQLREQL EHIRTHELHL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
  • 基因功能參考文獻:
    1. Ang II increased Csk expression and induced podocyte apoptosis, stimulated Csk translocation and binding to Caveolin-1. PMID: 27225249
    2. Recognition of Src-family kinases (SFKs) by Csk is mainly governed by interactions between motifs located distally from the active site of Csk and determinants spatially separate from the carboxyl-terminal regulatory tyrosine residue in SFKs. PMID: 21699177
    3. elucidation of molecular structure to determine regulation of Src family tyrosine kinases PMID: 11884384
    4. A series of 5,7-disubstituted quinazolines, bearing 4-heteroaryl substituents such as 2-pyridinylamine or 2-pyrazinylamine, has been synthetised and evaluated as c-Src kinase inhibitors PMID: 16203139
    5. Adrenomedullin attenuates the angiotensin II-induced increase in reactive oxygen species in vascular smooth muscle cells via activation of Csk, thereby inhibiting Src activity PMID: 17071733
    6. These results suggest novel roles for ZO proteins as Src/Csk scaffolds potentially involved in the regulation of Src transformation. PMID: 18086565

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, CSK subfamily
  • 組織特異性:
    Enriched in lymphoid tissues.
  • 數據庫鏈接:


主站蜘蛛池模板: 免费看美女被靠到爽的视频| 午夜福利午夜福利1000| 亚洲日韩国产一区二区三区在线| 性高朝久久久久久久| 一本色道久久hezyo无码| 婷婷五月综合激情中文字幕 | 又色又爽又黄还免费毛片96下载| 欧美日本免费一区二区三区| 国外av无码精品国产精品| 中年人妻丰满av无码久久不卡| 欲色影视天天一区二区色香欲| 亚洲欧美日韩一区二区| 毛片无码一区二区三区a片视频| 无码国产精品一区二区免费vr | 亚洲欧美日产综合在线| 精品成人av一区二区三区| 浴室人妻的情欲hd三级| 中文字日产乱码免费1~3软件| 大香网伊人久久综合网2018| 亚洲日韩欧洲乱码av夜夜摸| 国产又爽又黄无码无遮挡在线观看| 国精品人妻无码一区免费视频电影| 亚洲国产人在线播放首页| 久久99国产亚洲高清观看首页| 男女吃奶做爰猛烈紧视频| 137裸交肉体摄影| 精品一品国产午夜福利视频| 激情内射日本一区二区三区| 亚洲人成精品久久久久桥| 亚洲a片成人无码久久精品色欲| 久久久精品人妻一区二区三区蜜桃| 国产爆乳无码一区二区麻豆| 国产毛片一区二区精品| 国产在线不卡精品网站| 色翁荡熄又大又硬又粗又视频| 亚洲成a人片77777国产| 久久成人伊人欧洲精品| 四虎国产精品免费久久久| 婷婷四房综合激情五月在线| 三级无码在钱av无码在钱 | 精品国产自在精品国产精华天|