Recombinant Rat Thyrotropin subunit beta (Tshb)

^{In Stock}

中文名稱：

大鼠Tshb重組蛋白
貨號：

CSB-YP025130RA
規格：

￥2208
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Tshb
Uniprot No.：

P04652
別名：

TshbThyrotropin subunit beta; Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
來源：

Yeast
分子量：

16.4 kDa
表達區域：

21-132aa
氨基酸序列

FCIPTEYMMYVDRRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFTYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHEAVKTNYCTKPQTFY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged and C-terminal Myc-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Tris-based buffer,50% glycerol
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產品描述：

Recombinant Rat Thyrotropin subunit beta (Tshb) is a partial-length protein expressed with an N-terminal 6xHis-tagged and C-terminal Myc-tagged in the yeast. Its expression region corresponds to 21-132aa of rat Tshb protein. Its purity was determined by SDS-PAGE and reached up to 90% and presented a molecular mass band around 18.4 kDa on the gel. This recombinant Tshb protein may be used to synthesize antibodies against Tshb or on the studies of Tshb-associated signal transduction.
Tshb is indispensable for the control of thyroid structure and metabolism. Thyroid stimulating hormone consists of two subunits, alpha and beta. The TSHB gene encodes the beta subunit. The alpha and beta subunits are bound together to produce the active form of the hormone. Mutations in this gene can result in congenital central and secondary hypothyroidism and Hashimoto's thyroiditis.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Indispensable for the control of thyroid structure and metabolism.
基因功能參考文獻：
1. These data add new insight to an important role of T3 in rapidly regulating TSH beta gene expression at posttranscriptional level. PMID: 21078364
2. TSH action stimulates the phosphorylation of hsp-90 in FRTL-5 thyroid cells PMID: 16910874
3. Results clearly show that there are diurnal changes in TSH expression and accumulation in rat PT-TSH cells and suggest that these fluctuations are regulated by melatonin. PMID: 17927662
亞細胞定位：

Secreted.
蛋白家族：

Glycoprotein hormones subunit beta family
數據庫鏈接：

KEGG: rno:25653

STRING: 10116.ENSRNOP00000022575

UniGene: Rn.9966