在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Survival motor neuron protein (Smn1)

Recombinant Rat Survival motor neuron protein (Smn1)

  • 中文名稱：
    大鼠Smn1重組蛋白
  • 貨號：
    CSB-YP021838RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Smn1重組蛋白
  • 貨號：
    CSB-EP021838RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Smn1重組蛋白
  • 貨號：
    CSB-EP021838RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Smn1重組蛋白
  • 貨號：
    CSB-BP021838RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Smn1重組蛋白
  • 貨號：
    CSB-MP021838RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Smn1; SmnSurvival motor neuron protein
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-289
  • 氨基酸序列
    MAMGSGGGAG SEQEDTVLFR RGTGQSDDSD IWDDTALIKA YDKAVASFKH ALKNGDMCET SDKPKGTARR KPAKKNKNQK KNATAPLKQW KAGDKCSAVW SEDGCVYPAT ITSVDLKRET CVVVYTGYGN KEEQNLSDLL SPTCEVANNT EQNTQENESQ VSTDDSEHSS RSLRSKAHSK SKAAPWTSFL PPPPPVPGAG LGPGKPGLRF SGPPPPPPPP PPFLPCWMPP FPSGPPIIPP PPPISPDCLD DTDALGSMLI SWYMSGYHTG YYMGFRQNKK EGKKCSHTN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
  • 基因功能參考文獻：
    1. Report decreased number of motor neurons and a decrease of SMN1 protein expression in spinal cords of rats exposed to uranyl nitrate. PMID: 27153795
    2. Reduced SMN protein level alters miRNA expression and distribution in neurons. PMID: 25055867
    3. Involvement of SMN in formation of stress granules may play an important role in cell survival. PMID: 21234798
    4. RNAi-mediated degradation of endogenous Elk-1 resulted in elimination of the mcl-1 message PMID: 21362474
    5. The highest expression is associated with the cell clustering phase and expression of NMDA receptors PMID: 12030329
    6. Data show differential localization of the 18- and 23-kDa fibroblast growth factor 2 isoforms in the nuclei of rat Schwann cells, and that the 23-kDa isoform co-immunoprecipitates specifically with the survival of motor neuron protein. PMID: 12397076
    7. SMN interacts with non-methylated EWS and an EWS-derived RG-containing peptide. Symmetrical dimethylation of the EWS-derived RG-peptide increases the dissociation rate between SMN and the symmetrical dimethylated EWS RG-peptide. PMID: 14597228
    8. Data show that the rat survival motor neuron cDNA produces two isoforms with molecular weight of 32 and 35kDa, both localized in nuclear coiled bodies, but the 32kDa form is also cytoplasmic, whereas the 35kDa form is also microsomal. PMID: 15465016
    9. Forced expression of a-SMN isoform stimulates motor neuron axonogenesis in a time-dependent fashion and induces axonal-like growth in non-neuronal cells. PMID: 17261814
    10. selective overexpression of the SMN C-terminal domain promoted neurite outgrowth similar to full-length protein and could rescue the SMN knock-down effects PMID: 17317728
    11. Smn knockdown in PC12 cells alters the expression pattern of profilin II, resulting in an increase in the neuronal-specific profilin IIa isoform. PMID: 17873296

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    SMN family
  • 數據庫鏈接：


主站蜘蛛池模板： 精品国内在视频线2019| 国产精品第一区揄拍无码| 无码人妻h动漫| 欧美内射rape视频| 国产日韩精品欧美2020区| 色一情一乱一乱一区99av| 亚洲欧洲国产成人综合在线观看| 伊伊人成亚洲综合人网7777| 日本精品一区二区三区四区| 成人美女黄网站色大色费全看| 亚洲 欧美 国产 动漫 综合| 6080yyy午夜理论片中无码 | 国产日韩成人内射视频| 欧美性受xxxx黑人xyx性爽| 国产成人无码18禁午夜福利网址| 天下第一社区视频www日本| 在线精品视频一区二区三区| 欧美成人午夜免费全部完| 国产精品最新免费视频| 男人的天堂2018无码| 黄网在线观看免费网站| 色资源av中文无码先锋| 精品久久久久久中文墓无码| 麻豆国产成人av高清在线| 亚洲午夜福利在线观看| 超碰国产精品人人做人人爱| 亚洲五月综合缴情在线观看| 精品国产天线2019| 人成午夜大片免费视频77777| 国产精品成人一区二区不卡| 亚洲人成电影网站在线观看| 蜜芽久久人人超碰爱香蕉| 日韩国产亚洲欧美中国v| 少妇高潮太爽了在线观看欧美| 欧美影院成年免费版| 日日噜噜夜夜狠狠久久蜜桃| 中文国产成人精品久久久| 亚洲午夜无码久久| 久久久精品人妻一区二区三区| 亚洲已满18点击进入在线观看| 99久久人妻精品免费一区|