在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Stromal interaction molecule 1 (Stim1), partial

Recombinant Rat Stromal interaction molecule 1 (Stim1), partial

  • 中文名稱：
    大鼠Stim1重組蛋白
  • 貨號：
    CSB-YP022829RA1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Stim1重組蛋白
  • 貨號：
    CSB-EP022829RA1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Stim1重組蛋白
  • 貨號：
    CSB-EP022829RA1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Stim1重組蛋白
  • 貨號：
    CSB-BP022829RA1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Stim1重組蛋白
  • 貨號：
    CSB-MP022829RA1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Stim1; Sim; Stromal interaction molecule 1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch.
  • 基因功能參考文獻：
    1. Suppression of STIM1 reduced intracellular calcium level and attenuated hypoxia/reoxygenation induced apoptosis in H9C2 cardiomyocytes. PMID: 29089467
    2. downregulation of miR-223 by phenylephrine contributed to the increase of STIM1, which in turn induced cardiac hypertrophy. PMID: 29110214
    3. STIM1 may play an important role in the pathogenesis of alcoholic liver disease. PMID: 29704510
    4. The function of STIM1 in the regulation of the store-operated Ca(2+)-entry in astrocytes PMID: 27237974
    5. that sub-lethal levels of proteasome inhibition reduce store-operated calcium entry and promote autophagy-mediated degradation of STIM1 and STIM2 PMID: 26960935
    6. STIM1 binding to phospholamban contributes to the regulation of SERCA2a activity in the steady state and rate of SR Ca(2+) leak and that these actions are independent of store-operated Ca(2+) entry, a process that is absent in normal heart cells PMID: 26261328
    7. Studied the effect of STIM1 knockdown on the proliferation and migration of endothelial progenitor cells (EPCs) after vascular injury and its mechanism. PMID: 25063063
    8. Knockdown of STIM1 blocked degradation of Sp4, whereas expression of constitutively active STIM1 decreased Sp4 abundance under depolarizing conditions. PMID: 24894994
    9. Our results suggested that Stim1 is a strong candidate gene responsible for the exaggerated sympathetic response to stress in SHRSP. PMID: 24736434
    10. This study demonistrated that inhibition of stim1 expression and decreased the intracellular calcium concentration in neurons. PMID: 24509424
    11. Experimental subarachnoid hemorrhage significantly increased mRNA and protein expressions of STIM1 in rats. PMID: 23542055
    12. Silencing of STIM1 significantly decreases cellular proliferation and delayed cell cycle progression induced by hypoxia. PMID: 23289723
    13. These results indicate enhanced STIM1 expression due to diffuse axonal injury PMID: 23261659
    14. The overexpression of STIM1 increased by twofold the Ca(2+) influx evoked by thrombin, while knockdown of endogenous STIM1 significantly decreased this Ca(2+) influx. PMID: 22944608
    15. Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes PMID: 22992728
    16. STIM1 is essential for correct growth cone navigation and plays multiple roles in growth cone motility, including activation of store-operated calcium entry (SOCE). PMID: 22712562
    17. By controlling a previously unrecognized sarcolemmal current, STIM1 promotes cardiac hypertrophy. PMID: 21810664
    18. STIM1 is a potent regulator of cell proliferation and migration in rat endothelial progenitor cells (EPCs) and may play an important role in the biological properties of EPCs. PMID: 20599714
    19. HGF-induced EPC proliferation is mediated partly via activation of STIM1 PMID: 20404049
    20. proposal that STIM1 functions as the missing link between Ca2+ store depletion and store-operated calcium influx, serving as a Ca2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels PMID: 16208375
    21. suppression of store-operated channels function by Orai1 overexpression likely reflects a required stoichiometry between STIM1 and Orai1 PMID: 16766533
    22. Knockdown of STIM1 (stromal interaction molecule type 1) by siRNA also resulted in a significant reduction (approx. 80% at 72 h post-transfection) of the I(SOC) amplitude. PMID: 17432954
    23. Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia.( PMID: 18424621
    24. Knockdown of Stim1 inhibits endothelial proliferation and causes cell cycle arrest at S and G2/M phase. PMID: 18845811
    25. Results suggest STIM1 has a critical role in neointimal formation in a rat model of vascular injury. PMID: 19052075
    26. STIM1 appears as a major regulator of in vitro and in vivo vascular smooth muscle cell proliferation, representing a novel and original pharmacological target for prominent vascular proliferative diseases PMID: 19107116
    27. STIM1 was quantitatively more important than STIM2 in activation of store-operated channels in rat distal pulmonary arterial smooth muscle cells. PMID: 19395668

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Sarcoplasmic reticulum. Cytoplasm, cytoskeleton.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 亚洲图片校园另激情类小说| 西西人体大胆4444www| 国产ae86亚洲福利入口| 亚洲国产成人精品激情姿源 | 国内精品久久人妻无码网站| 色婷婷五月综合色啪网| 中文字幕人妻无码视频| 色狠狠一区二区三区香蕉| 亚洲高请码在线精品av| 久久九九国产精品怡红院| 久久综合九色综合欧美98| 婷婷成人丁香五月综合激情| 国产精品毛片在线完整版| 免费的av网站手机版| 艳妇乳肉豪妇荡乳av| 欧美日韩精品一区二区三区不卡| 成人精品一区二区三区电影免费| 人妻出差精油按摩被中出| 2019日韩中文字幕mv| 国产一区二区女内射| 亚洲综合狠狠丁香五月| 精品亚洲aⅴ在线无码播放| 国产精品久久久久无码av| 国产真实乱人偷精品视频| 亚洲日韩穿丝袜在线推荐| 久久久日韩精品一区二区三区| 国产成人无码a区在线观看导航| 无码欧美黑人xxx一区二区三区| 欧美白人最猛性xxxxx| 好吊妞国产欧美日韩免费观看| 国产精品香港三级国产av| 亚洲精品久久国产精品浴池| 久久久久国产精品熟女影院| 欧美最猛性xxxxx免费| 国产精品人妻久久毛片高清无卡 | 摸丰满大乳奶水www免费| 夜夜欢性恔免费视频| 亚洲色无码播放| 99国产精品人妻噜啊噜| 国产成人精品日本亚洲一区| 影视先锋男人无码在线|