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  4. Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-2 (Atp1a2), partial

Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-2 (Atp1a2), partial

  • 中文名稱：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 貨號：
    CSB-YP002323RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 貨號：
    CSB-EP002323RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 貨號：
    CSB-EP002323RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 貨號：
    CSB-BP002323RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 貨號：
    CSB-MP002323RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Atp1a2Sodium/potassium-transporting ATPase subunit alpha-2; Na(+)/K(+) ATPase alpha-2 subunit; EC 7.2.2.13; Na(+)/K(+) ATPase alpha(+) subunit; Sodium pump subunit alpha-2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • 基因功能參考文獻：
    1. cardiomyocyte ATP1A2 is a target of A/R injury PMID: 29394489
    2. Hypoxia reduces smooth muscle cell expression of Atp1a2 which may contribute to basilar artery vasoconstriction. PMID: 26924456
    3. Data suggest that, in polycystic ovary syndrome, heart exhibits alteration in processing of Atp1a2 (Na+/K+ transporting ATPase alpha 2) with decreases in plasma membrane content of this enzyme subunit. PMID: 25988879
    4. Na-K-ATPase alpha2 does not regulate Src. PMID: 26108663
    5. Na,K-ATPase alterations precede hindlimb suspension-induced muscle atrophy. PMID: 25654120
    6. Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease PMID: 24356962
    7. Results suggest that the increase in the Na(+)/water ratio and a reduction in ATP1alpha2 may be associated with cerebral aneurysm formation. PMID: 23045463
    8. The nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle. PMID: 20595385
    9. The Na+K+ ATPase alpha 2 subunit is localized in astrocytic processes around axonal or dendritic elements of glutamatergic axo-dendritic synaptic junctions in the frontoparietal somatosensory cortex. PMID: 11950769
    10. Structural basis for alpha1 versus alpha2 isoform-distinct behavior of the Na,K-ATPase PMID: 12529322
    11. beta(1)-Na(+),K(+)-ATPase is likely to represent the most physiologic and efficient subunit for HKalpha(2) assembly in distal colon. PMID: 15327400
    12. missense mutants R689Q and M731T have reduced catalytic turnover and increased apparent affinity for extracellular K(+) PMID: 16037212
    13. cyclic stretch mainly stimulated translocation of alpha2-subunit of Na+-K+-ATPase from endosomes to the plasma membrane via a PI 3-kinase-dependent mechanism in cultured skeletal muscle cells in vitro, which in turn increased the activity of the Na pump. PMID: 16893515
    14. The functional density of NKA-alpha2 is approximately 4.5 times higher in the T-tubules vs. external sarcolemma in ventricular cardiomyocytes. PMID: 17392375
    15. Downregulation of Atp1a2 attenuated control of Na/Ca exchanger activity in heart failure, reducing its capability to extrude Ca2+ from cardiomyocytes. PMID: 18203708
    16. Protein and mRNA levels for Na(+)-K(+)-ATPase alpha2 isoform were decreased in failing hearts. This was prevented by analapril or losartan. PMID: 18418421
    17. Analysis of exercise-induced Na+-K+ exchange in rat skeletal muscle in vivo. PMID: 18586859
    18. Disturbances in skeletal muscle Na(+)-K(+)-ATPase regulation, particularly the alpha(2)-subunit, may contribute to impaired ion homeostasis in insulin-resistant states such as obesity and type 2 diabetes. PMID: 19366873

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  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
  • 數據庫鏈接：


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