在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Sodium channel protein type 1 subunit alpha (Scn1a), partial

Recombinant Rat Sodium channel protein type 1 subunit alpha (Scn1a), partial

  • 中文名稱：
    大鼠Scn1a重組蛋白
  • 貨號：
    CSB-YP020834RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Scn1a重組蛋白
  • 貨號：
    CSB-EP020834RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Scn1a重組蛋白
  • 貨號：
    CSB-EP020834RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Scn1a重組蛋白
  • 貨號：
    CSB-BP020834RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Scn1a重組蛋白
  • 貨號：
    CSB-MP020834RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Scn1a; Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.
  • 基因功能參考文獻：
    1. Nav1.1 in facilitates fast-firing properties in medial septum neurons. Nav1.1 deficits may disrupt information processing in Dravet syndrome via a dysregulation of theta wave brain rhythms. PMID: 26978272
    2. Scn1a mutant rats demonstrate a higher hyperthermia-induced seizure susceptibility than wild type rats. PMID: 23375560
    3. Hyperthermia-induced seizures occurred in Scn1a mutant rats at high-frequency electroencephalographic oscillations. PMID: 22920678
    4. We show that reduction of Nav1.1 expression in the medial septum and diagonal band of Broca leads to a dysregulation of hippocampal oscillations in association with a spatial memory deficit PMID: 23318929
    5. In the dorsal horn of the developing rat, Na(v) isoforms are developmentally regulated at the mRNA level in a subtype-specific manner, as Na(v)1.2 and Na(v)1.3 decreased significantly from P3 to adulthood, while Na(v)1.1 was upregulated during this period PMID: 23219908
    6. Identification of the cysteine residue responsible for disulfide linkage of Na+ channel alpha and beta2 subunits PMID: 22992729
    7. Results suggest that an early increase in dorsal root ganglion Nav1.1 expression after peripheral nerve injury might be involved in the induction of neuropathic pain. PMID: 21714116
    8. Hyperthermia-induced seizure-susceptible rats are associated with febrile seizures and display the hyperexcitability of limbic neurons associated with the Scn1a missense mutation. PMID: 20875856
    9. An important mechanism of electroacupuncture therapy is its regulation of Nav1.6 and Nav1.1 expression after ischemia. PMID: 20483028
    10. Scn1a missense mutation preferentially impairs GABA(A) receptor-mediated synaptic transmission without directly altering the excitability of the pyramidal neurons in the hippocampus, which may be linked to the pathogenesis of febrile seizures. PMID: 20707984
    11. TTX-sensitive sodium channel alpha-subunit isoforms Na(v)1.1, Na(v)1.2, Na(v)1.3, Na(v)1.4 and Na(v)1.6 were detected in neonatal rat heart but at levels reduced compared to the predominant cardiac alpha-subunit isoform, Na(v)1.5. PMID: 19426735
    12. Quantitative and relative changes in expression of NaCh genes in neurons following injury produced by selective activation of voltage-gated sodium channels. Gene Nav1.1. may play role in neuronal injury/recovery process. PMID: 12835125
    13. A novel site of high-density sodium channel clustering in the inner plexiform layer of the retina is described, marked by ankyrin-G and neurofascin. PMID: 15797713
    14. these data map the time-dependent loss of Na(v)1.1 mRNA and protein following focal ischemic brain injury PMID: 15878599
    15. Na(V)1.1 was distributed in a similar manner to Na(V)1.5: atrial & ventricular myocardium & the left bundle branch, the inferior nodal extension & transitional zone. PMID: 16966585
    16. Results suggest that transient cerebral ischemia renders CA1 interneurons less excitable, that depressed excitability involves impaired Na(+) channel activation and that Na(+) channel dysfunction is explained by reduced expression of the Na(v)1.1 subunit. PMID: 17228331
    17. This study combined ISH with immunohistochemistry and discovered that most of the PV-immunoreactive cells located at the INL/IPL border express Nav1.1. Our results show that AII amacrine cells express Nav1.1. PMID: 17709186

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium channel (TC 1.A.1.10) family, Nav1.1/SCN1A subfamily
  • 數據庫鏈接：


主站蜘蛛池模板： 久久免费精品国产72精品| 五月丁香啪啪| 国产精品岛国久久久久| 亚洲国产精品无码中文在线| 免费人成网站在线视频| 精品一区二区三区四区五区六区| 99re6在线视频精品免费下载| 国产熟妇高潮呻吟喷水| 97色成人综合网站| 熟妇高潮一区二区三区| 精品国产三级在线观看| 国产一区二区野外| 日韩精品无码人成视频| 精品国偷自产在线视频| 欧美性生交大片18禁止| 四虎亚洲精品成人a在线观看| 老男人久久青草av高清| 精品人妻无码一区二区色欲产成人 | 麻豆tv入口在线看| 精品午夜国产福利观看| 亚洲色无码播放| 成人免费国产精品视频| 97碰碰碰免费公开在线视频| 国产99久久久国产无需播放器| 国产成人无码一区二区在线播放| 久久亚洲私人国产精品| 久久视频这里只精品| 老女老肥熟国产在线视频| 国产午夜激无码av毛片不卡| 久久久久爽爽爽爽一区老女人| 亚洲 欧美 清纯 校园 另类| 大伊香蕉精品视频在线| 婷婷久久综合九色综合88| 男男女女爽爽爽免费视频 | 女人被爽到高潮视频免费国产| 在线天堂最新版资源| 国产亚洲精品久久久久蜜臀| 成在人线av无码免观看麻豆| 国产精品久久久久久av福利| 国产大片黄在线观看| 精品国产乱码久久久久软件|