在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Sodium/bile acid cotransporter (Slc10a1), partial

Recombinant Rat Sodium/bile acid cotransporter (Slc10a1), partial

  • 中文名稱：
    大鼠Slc10a1重組蛋白
  • 貨號：
    CSB-YP021373RA1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Slc10a1重組蛋白
  • 貨號：
    CSB-EP021373RA1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Slc10a1重組蛋白
  • 貨號：
    CSB-EP021373RA1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Slc10a1重組蛋白
  • 貨號：
    CSB-BP021373RA1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Slc10a1重組蛋白
  • 貨號：
    CSB-MP021373RA1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Slc10a1; Ntcp; Sodium/bile acid cotransporter; Na(+/bile acid cotransporter; Na(+/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
  • 基因功能參考文獻：
    1. Administration of glucocorticoids (GCs) enhanced liver bile acid uptake by increasing the expression of the major hepatocyte basolateral bile transporter (Ntcp)in rats. The reduced expression of a bile acid synthesis rate-controlling enzyme, Cyp7a1, suggests that treatment with GCs suppressed hepatic bile acid synthesis. PMID: 27133208
    2. Ntcp plasma membrane localization is regulated by hyperosmolarity and tauroursodeoxycholate PMID: 26306036
    3. Taurocholate (TCA) for Ntcp. PMID: 25305012
    4. This study identified a motif which is critical for Ntcp plasma membrane localization. PMID: 24008362
    5. hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis PMID: 23125159
    6. sustained repression and translocation of Ntcp and the expression of Mrp4 at the basolateral membrane seem to be responsible for the high blood bile acids levels after massive hepatectomy PMID: 21167233
    7. Ca(2+)-dependent PKCs induce vesicular retrieval of Ntcp, thereby reducing bile salt uptake. Short-term downregulation of Ntcp by endocytosis may be important mechanism to protect hepatocytes from effects of toxic intracellular bile salt concentrations. PMID: 20539008
    8. translocation requires activation of protein kinase B PMID: 12034724
    9. Pregnancy is associated with reduced Ntcp expression and function in the rat PMID: 12547402
    10. Results show that loop amino acids are required for sodium-dependent substrate translocation by the sodium-dependent taurocholate cotransporting polypeptide Ntcp. PMID: 12631271
    11. Substrate specificity of ntcp is considerably broader than previously suspected and caution extrapolation of transport data obtained in vitro to physiological function in vivo. PMID: 12842829
    12. TNF-alpha represents the master cytokine responsible for HNF1-dependent down-regulation of Ntcp in CCl(4)-induced toxic liver injury and IL-1 beta predominates in a complex signaling network of Ntcp regulation in cholestatic liver injury PMID: 12883478
    13. Physiological significance of cross-talk between ERalpha and Stat5a in liver, in which both proteins are expressed. Novel mechanism by which expression of ntcp, an important hepatic bile acid transporter, can be regulated by multiple hormones. PMID: 14684617
    14. Conserved NTCP/Ntcp 5'-regulatory region transcription regulation differs among species and is not directly regulated by small heterodimer partner. Bile acids may regulate NTCP/Ntcp indirectly by modulating nuclear factor regulation of gene expression. PMID: 14701722
    15. Data show that endogenous thyroxine but not corticosterone regulates the developmentally timed appearance of the apical sodium-dependent bile acid transporter. PMID: 14711893
    16. pituitary hormones play an essential role in the sexually dimorphic control of Ntcp expression in adult rat liver and in the mediation of estrogen effects. PMID: 15361361
    17. Results suggest that the Ser-226 in the third cytoplasmic loop of Ntcp is phosphorylated and cAMP may increase Ntcp translocation to the cell membrane by dephosphorylating Ntcp at this site. PMID: 16027164
    18. analysis of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter PMID: 16608845
    19. In hypoxic liver tissue, a marked reduction in the mRNA levels of Na(+)-taurocholate-cotransporting polypeptide (Ntcp was detected before bile duct proliferation occurred PMID: 17615179
    20. Upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway. PMID: 17640976
    21. Report PKCepsilon-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line. PMID: 19815625

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Bile acid:sodium symporter (BASS) (TC 2.A.28) family
  • 組織特異性：
    Liver and kidney.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲精品一区二区三区四区乱码| 久久爱www人成狠狠爱综合网| 日本护士xxxxhd少妇| 中文无码日韩欧免费视频 | 国产成人免费ā片在线观看| 国产成人综合在线女婷五月99播放| 亚洲成a人v电影在线观看| 久久精品一区二区免费播放| 香蕉久久福利院| 丁香五月亚洲综合深深爱| 18禁止观看强奷免费国产大片| 丰满少妇大力进入| 女人被男人爽到呻吟的视频| 色综合天天综合网中文| 日本丰满护士爆乳xxxx| 精品人妻av区波多野结衣| 国产97色在线 | 日韩| 大香线蕉伊人超碰| 99久热国产精品视频尤物| 国产大片黄在线观看| 无套内射视频囯产| 久久青青草原精品国产app| 欧美xxxx做受视频| 亚洲人成电影在线观看影院| 欧美亚洲国产精品久久蜜芽 | 亚洲精品久久久久国产剧8| 99久久久精品免费观看国产| 成人精品一区二区三区中文字幕 | 精品无人乱码一区二区三区的特点| 亚洲中文字幕无码中文| 久久久久国产精品人妻aⅴ果冻 | 午夜福利无遮挡十八禁视频| 性亚洲videofree高清| 亚洲午夜未满十八勿入网站| 伊人成年网站综合网| 免费无遮挡在线观看网站| 美女内射毛片在线看3d| 丰满诱人的人妻3| 婷婷四虎东京热无码群交双飞视频| 久久无码av一区二区三区电影网| 亚洲一区二区三区香蕉|