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  4. Recombinant Rat Signal-induced proliferation-associated 1-like protein 1 (Sipa1l1), partial

Recombinant Rat Signal-induced proliferation-associated 1-like protein 1 (Sipa1l1), partial

  • 中文名稱：
    大鼠Sipa1l1重組蛋白
  • 貨號：
    CSB-YP021331RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Sipa1l1重組蛋白
  • 貨號：
    CSB-EP021331RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Sipa1l1重組蛋白
  • 貨號：
    CSB-EP021331RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Sipa1l1重組蛋白
  • 貨號：
    CSB-BP021331RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Sipa1l1重組蛋白
  • 貨號：
    CSB-MP021331RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Sipa1l1; Spa1; Signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; SPA-1-like protein p1294; Spine-associated Rap GTPase-activating protein; SPAR
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis.
  • 基因功能參考文獻：
    1. The microwave radiation led to shrinkage and even loss of dendritic spines in hippocampus by SNK-SPAR pathway, resulting in the cognitive impairments. PMID: 29180226
    2. Prenatal stress increased spar in thr hippocampus of the offspring at adulthood in rats PMID: 23850969
    3. Long-term potentiation triggers downregulation of SPAR requiring ubiquitin proteasome system and NMDA receptor activation but not cyclin-dependent kinase (CDK)5. PMID: 21987493
    4. findings suggest that SPAL may be involved in the NMDA-mediated organization of cytoskeletal networks and signal transduction PMID: 12059963
    5. serum-inducible kinase bound to and phosphorylated spine-associated Rap guanosine triphosphatase activating protein (SPAR), a postsynaptic actin regulatory protein, leading to degradation of SPAR PMID: 14576440
    6. PSD-Zip70 in collaboration with SPAR is critically involved in spine maturity, especially in the mature spine formation and the maintenance of spine maturity. PMID: 15703396
    7. the multiple SPAR functional domains have been expressed in E. coli in quantities suitable for biophysical and biochemical studies, allowing us to investigate the role of the PDZ domain in SPAR function . PMID: 18678258

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptosome. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons.
  • 組織特異性：
    Detected in brain (at protein level).
  • 數據庫鏈接：


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