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  4. Recombinant Rat Serine protease inhibitor A3K (Serpina3k)

Recombinant Rat Serine protease inhibitor A3K (Serpina3k)

  • 中文名稱：
    大鼠Serpina3k重組蛋白
  • 貨號：
    CSB-YP361549RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Serpina3k重組蛋白
  • 貨號：
    CSB-EP361549RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Serpina3k重組蛋白
  • 貨號：
    CSB-BP361549RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Serpina3k重組蛋白
  • 貨號：
    CSB-MP361549RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Serpina3k
  • Uniprot No.：
  • 別名：
    Serpina3k; Spin2b; Serine protease inhibitor A3K; Serpin A3K; CPI-21; Contrapsin-like protease inhibitor 1; GHR-P63; Growth hormone-regulated proteinase inhibitor; Kallikrein-binding protein; KBP; SPI-2.3; Serine protease inhibitor 2; SPI-2; Thyroid hormone-regulated protein
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    full length protein
  • 表達區域：
    21-416
  • 氨基酸序列
    DGILGRDTLP HEDQGKGRQL HSLTLASINT DFTLSLYKKL ALRNPDKNVV FSPLSISAAL AILSLGAKDS TMEEILEVLK FNLTEITEEE IHQGFGHLLQ RLSQPEDQAE INTGSALFID KEQPILSEFQ EKTRALYQAE AFVADFKQCN EAKKFINDYV SNQTQGKIAE LFSELDERTS MVLVNYLLFK GKWKVPFNPN DTFESEFYLD EKRSVKVPMM KIKDLTTPYI RDEELSCSVL ELKYTGNASA LFILPDQGKM QQVESSLQPE TLKKWKDSLR PRIISELRMP KFSISTDYNL EEVLPELGIR KIFSQQADLS RITGTKNLHV SQVVHKAVLD VDETGTEGAA ATAVTAALKS LPQTIPLLNF NRPFMLVITD NNGQSVFFMG KVTNPM
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase.
  • 基因功能參考文獻：
    1. KBP suppressed lipopolysaccharide-induced TNF-alpha production via upregulating SOCS3 expression. PMID: 23129128
    2. KBP competed with (125)I-VEGF for binding to endothelial cells and down-regulated VEGF production in endothelial cells and in the retina of the oxygen-induced retinopathy rat model PMID: 12743698
    3. in a rat model of chronic mycardial infarction (MI) kallistatin improves cardiac performance and prevents post-MI-induced cardiac hypertrophy and fibrosis through its antioxidant action. PMID: 18762777
    4. An inverse relationship exists between oxidative stress and kallistatin levels in the circulation and blood vessels. Kallistatin expression is negatively regulated by oxidative stress via JNK-dependent FOXO1 activation in cultured endothelial cells. PMID: 20081110
    5. Pivotal role for alpha1-antichymotrypsin in skin repair PMID: 21693707
    6. SERPINA3K is an antifibrogenic factor, and its antifibrogenic activity is through blocking the Wnt pathway. Decreased SERPINA3K levels may contribute to the fibrosis in diabetic retinopathy. PMID: 20299474
    7. SERPINA3K is a high-affinity, endogenous antagonist of LRP6 PMID: 20351274

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Liver and plasma.
  • 數據庫鏈接：


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