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  4. Recombinant Rat Protein-tyrosine kinase 2-beta (Ptk2b), partial

Recombinant Rat Protein-tyrosine kinase 2-beta (Ptk2b), partial

  • 中文名稱：
    大鼠Ptk2b重組蛋白
  • 貨號：
    CSB-YP018994RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Ptk2b重組蛋白
  • 貨號：
    CSB-EP018994RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Ptk2b重組蛋白
  • 貨號：
    CSB-EP018994RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Ptk2b重組蛋白
  • 貨號：
    CSB-BP018994RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Ptk2b重組蛋白
  • 貨號：
    CSB-MP018994RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ptk2b; Fak2; Pyk2Protein-tyrosine kinase 2-beta; EC 2.7.10.2; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2.
  • 基因功能參考文獻：
    1. This study, identified the role of the Pyk2/MCU pathway in the regulation of mitochondrial Ca2+ uptake and apoptotic signaling after ischemic stroke. PMID: 28916471
    2. Pyk2 inhibition promotes contractile differentiation in carotid artery smooth muscle. PMID: 28019664
    3. Pyk2 is integrated to the PSD-95 signal complex in cortical neurons following Src protein phosphorylation. PMID: 24981431
    4. These findings suggested that Pyk2 was involved in ionomycin-induced neurotransmitter release through phosphorylation of Y402. PMID: 24718602
    5. depolarization-induced entry of Ca(2+) activates Pyk2 upstream of the RhoA/ROK pathway, leading to MYPT1 phosphorylation and MLCP inhibition. PMID: 25713079
    6. Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress PMID: 25349423
    7. Pyk2 localization is regulated by serine dephosphorylation in PC12 cells. PMID: 22802128
    8. Pyk2 plays a crucial role in G protein-coupled receptor agonist thrombin-induced human aortic smooth muscle cell growth and migration, as well as balloon injury-induced neointima formation. PMID: 22922962
    9. Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats. PMID: 21926342
    10. data suggest that PYK2 is an important upstream mediator in PDGF-dependent signaling cascades that regulate vascular smooth muscle cell proliferation PMID: 21451101
    11. Pyk2 acts as an early sensor of numerous extracellular signals that trigger a Ca(2+) flux and/or reactive oxygen species to amplify tyrosine phosphorylation signaling events. PMID: 20688918
    12. The data of this study indicated that PYK2 is critical for the induction of LTD, possibly in part by antagonizing ERK signaling in hippocampal neurons. PMID: 20826662
    13. Increased expression of CAKbeta was confirmed by anti-CAKbeta immunoblotting and by real-time quantitative polymerase chain reaction. PMID: 11774117
    14. Results delineate a cardiomyocyte signaling pathway involving pyk2/related focal adhesion tyrosine kinase (RAFTK) that has potential relevance for cardiac remodeling, focal adhesion reorganization, and loss of contractility. PMID: 12228222
    15. Details of the interactions of the proline-rich regions in the C-terminal half of Pyk2 with the SH3 domain and the guanylate kinase homology (GK)domain of PSD-95 and SAP102, and the physiological function of the interactions. PMID: 12576483
    16. Thrombin can evoke phosphorylation of Pyk2 via PAR-1 which activates Src leading to ERK1/2 activation, which predominantly recruits Grb2 in rat astrocytes PMID: 12614335
    17. results demonstrate that cholecystokinin stimulates tyrosine phosphorylation of three sites in focal adhesion kinase(p125 FAK) and PYK2 but differs in participation of cholecystokinin receptor A PMID: 12651850
    18. mechanical stretch stimulates activation of CAKbeta in vascular smooth muscle cells PMID: 12746290
    19. Pyk2, a non-receptor tyrosine kinase structurally related to focal adhesion kinase, has been implicated in the regulation of mitogen-activated protein kinase cascades and ion channels, the induction of apoptosis, and in the modulation of the cytoskeleton. PMID: 12771146
    20. Ca2+ influx through nonselective cation chanels plays an essential role in ET-1-induced PYK2 phosphorylation and PI3K is involved in the ET-1-induced PYK2 phosphorylation PMID: 12900387
    21. The results are consistent with a role for PKC in the ischemia-induced increase in tyrosine phosphorylation of the NMDAR, via a pathway involving Pyk2 and Src-family kinases PMID: 12950452
    22. interaction between PDK1 and Pyk2 that regulates the integrity of focal adhesions PMID: 14585963
    23. Proline-rich tyrosine kinase 2 (Pyk2)/cell adhesion kinase beta (CAKbeta), a Ca(2+)-sensitive non-receptor tyrosine kinase, is involved in ET-1- and PE-induced cardiomyocyte hypertrophy medicated through Rac1 activation. PMID: 15158121
    24. Reactive oxygen species are critical mediators of ET-1-induced signaling with ERK1/2, PKB, and Pyk2 which are linked to growth-promoting proliferative and hypertrophic pathways in vascular smooth muscle cells PMID: 15203192
    25. RAFTK/pyk2 triggers cardiomyocyte apoptosis via Src kinase, which is antagonized by paxillin PMID: 15322113
    26. In mesenteric arteries an intact cytoskeleton and force development are necessary for the translocation of PYK2 and paxillin to the membrane. PMID: 15911746
    27. Pyk2 plays a central role in the migratory behavior of glioblastomas PMID: 15967096
    28. These results implicate Ca2+ and multiple forms of PKC in the activation of Pyk2 downstream of NMDA receptors and suggest that cAMP-dependent processes exert a suppressive action on Pyk2. PMID: 16120467
    29. RAFTK is a key signaling molecule that mediates LPA-induced PC12 cell migration in a Ras-dependent manner. PMID: 16199135
    30. NO, in a cGMP-dependent manner, attenuated ET-1-induced phosphorylation of ERK1/2, PKB, and Pyk2 and also antagonized the hypertrophic effects of ET-1. PMID: 17644565
    31. Results show that depolarization independently induces nuclear translocation and tyrosine phosphorylation of PYK2, and that both responses require calcineurin activation. PMID: 17684059
    32. crucial role for a proline-rich tyrosine kinase 2-signaling complex in the endothelial response to salt intake PMID: 18981321
    33. PYK2 and PDZ-RhoGEF are necessary for angiotensin II-induced RhoA activation and for Ca(2+) signaling to RhoA. PMID: 19759375

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus.; [Isoform 2]: Cell junction, focal adhesion. Note=Localizes to focal adhesions, but not isoform 1 and isoform 3.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, FAK subfamily
  • 組織特異性：
    Highly expressed in pulmonary vein endothelial cells, lung and brain (at protein level). Isoform 1 is expressed at high levels in the brain (hippocampus, cerebral cortex and olfactory bulb) and poorly in the spleen and other tissues, whereas isoforms 2 an
  • 數據庫鏈接：


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