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  4. Recombinant Rat Potassium voltage-gated channel subfamily H member 2 (Kcnh2), partial

Recombinant Rat Potassium voltage-gated channel subfamily H member 2 (Kcnh2), partial

  • 中文名稱：
    大鼠Kcnh2重組蛋白
  • 貨號：
    CSB-YP012036RA
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Kcnh2重組蛋白
  • 貨號：
    CSB-EP012036RA
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Kcnh2重組蛋白
  • 貨號：
    CSB-EP012036RA-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Kcnh2重組蛋白
  • 貨號：
    CSB-BP012036RA
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Kcnh2重組蛋白
  • 貨號：
    CSB-MP012036RA
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcnh2
  • Uniprot No.：
  • 別名：
    Kcnh2; Erg; Potassium voltage-gated channel subfamily H member 2; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; RERG; r-ERG; Voltage-gated potassium channel subunit Kv11.1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
  • 基因功能參考文獻：
    1. PKD1 mediates the PKC effects on KV11.1 and we found that PKD targets S284 in the N-terminus of the channel. PMID: 29949809
    2. Allosteric modulation of the Kv11.1 channel efficiently suppresses drug-induced ventricular arrhythmias in vitro by preventing potentially arrhythmogenic changes in action potential characteristics PMID: 27071825
    3. KCNH-2 and KCNE-2 potassium channels are molecular subunits of an inwardly rectifying potassium channel complex. PMID: 19913309
    4. The ERG1 displays a heterogeneous distribution in the rat kidney. PMID: 19921238
    5. The localization of ERG1 to the transverse tubular system close to the Ca(2+) channels renders it with maximal repolarizing effect PMID: 14670813
    6. thyrotropin-releasing hormone (TRH) effects on the biophysical properties of homomeric erg1b and heteromeric erg1a/1b channels; most effects of TRHon heteromeric rerg1 channels were dominated by the rerg1b subunit PMID: 16339175
    7. Kcnh2 (Erg1) is expressed in rat pancreatic beta cells. Pharmacological channel blockers indicate a function within the insulin secretion process. Differential expression of Erg1 splice variants a and b in alpha and beta cells was detected. PMID: 17322986

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.1/KCNH2 sub-subfamily
  • 組織特異性：
    Highly expressed in brain and testis, slightly less so in heart, adrenal, retina and thymus. Detected at lower levels in lung, soleus, tibialis, and at very low levels in cornea and lens. A shorter transcript is detected in skeletal muscle. Found in pitui
  • 數據庫鏈接：


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