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  4. Recombinant Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Hcn4), partial

Recombinant Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Hcn4), partial

  • 中文名稱：
    大鼠Hcn4重組蛋白
  • 貨號：
    CSB-YP872866RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Hcn4重組蛋白
  • 貨號：
    CSB-EP872866RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Hcn4重組蛋白
  • 貨號：
    CSB-EP872866RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Hcn4重組蛋白
  • 貨號：
    CSB-BP872866RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Hcn4重組蛋白
  • 貨號：
    CSB-MP872866RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Hcn4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.
  • 基因功能參考文獻：
    1. Data suggest that HCN channels might play an important role in affecting contraction frequency of lymphatic muscle cells. PMID: 27496876
    2. the expression and relative abundances of HCN channels in cerebellum and primary cultures of cerebellar granule neurons, is described. PMID: 27569278
    3. involved in microwave-induced heart pacemaker cell injuries PMID: 26695361
    4. Spironolactone increased miRNA-1 expression in myocardium after myocardial infarction. Upregulation of miRNA-1 expression contributed to the posttranscriptional repression of HCN2/4 expression. PMID: 26065643
    5. The results of this study indicated that HCN4 subunits are expressed in several populations of spinal and hippocampal interneurons. PMID: 23357121
    6. The data of this study indicated a HCN subunit shift initiated in the first 24 hours after birth and implicate a prominent perinatal role of the phylogenetically older HCN3 and/or HCN4 subunits in the developing neocortex. PMID: 22694806
    7. first report that Thy1 colocalizes and coimmunoprecipitates with a membrane-spanning protein in retina, that Thy1 complexes with an ion channel protein in any tissue, and that a GPI-anchored protein associates with an HCN channel subunit protein (HDN4) PMID: 22281825
    8. The moderate-intensity HCN4 band density in trigeminal ganglion neurons increased with postnatal age P1-P35. PMID: 21753027
    9. This study demonistrated that the majority of LHb neurons projecting to the monoaminergic brainstem nuclei express a similar pattern of HCN transcripts, with high levels of HCN2 to HCN4 mRNAs and low levels of HCN1 mRNA. PMID: 21798320
    10. Results describe HCN1 and HCN4 immunoreactivity in rat retinal ganglion cells, measure I(h) in dissociated cells, and show that HCN1 and HCN4 proteins colocalize in single retinal ganglion cells. PMID: 21456027
    11. HCN1 and HCN4 in postnatal afferent fibers and HCN1, HCN2, and HCN4 after hearing onset; HCN channels mediate hyperpolarization-activated current (I(h)); results suggest that I(h) is active at rest and shortens EPSPs, potentially improving signaling PMID: 20220080
    12. HCN4 was present in 9% of rat trigeminal ganglion neurons and 4.7% of dorsal root ganglion neurons PMID: 19820968
    13. densely clustered at synaptic terminals of retinal bipolar cells and photoreceptors PMID: 12786975
    14. Immunoreactivity for HCN4 in rat brain exhibits subcortical distribution mainly concentrated in the thalamus. PMID: 14991560
    15. We explored the functional role of the I(H) channels in sensory neurons isolated from rat nodose ganglia. Immunohistochemical studies demonstrated differential distribution of HCN1, HCN2, and HCN4 in sensory neurons and peripheral nerve terminals PMID: 15056713
    16. subcellular expression patterns of the HCN channel isoforms support age-specific properties and functions of I(h) within the developing hippocampal formation PMID: 16648453
    17. Our data extend our previous discovery of Ca(2+) influx in I(h) channels in neurons to I(f) channels in cardiac myocytes. PMID: 17065201
    18. We conclude that the NRSE-NRSF system was implicated in HCN4 expression in cardiac myocytes. PMID: 17173866
    19. findings confirm presence of HCN-1, -2, and -4 in cone bipolar cells and provide evidence that the type 5 cone bipolar cell includes two distinct cell types, only one of which expresses HCN channels PMID: 17311321
    20. HCN2-HCN4 heteromeric channels form in native tissue to make functional pacemaker channels PMID: 17553794
    21. Adult VCM in primary culture undergo changes in I(f) expression reminiscent of in vivo hypertrophy; endothelin-1 (but no angiotensin-II) seems to play a role in ionic remodeling. PMID: 18255311
    22. HCN4-like immunoreactivity in rat retinal ganglion cells. PMID: 18282314
    23. Recycling endosomes serve as an intracellular storage compartment for the cardiac pacemaker channels HCN2 and HCN4. PMID: 18326556
    24. In adult myocytes overexpressing HCN4, there was an associated increase in HCN2 mRNA. In neonatal myocytes in which HCN2 was knocked down, there was also a simultaneous decrease in HCN4 mRNA. PMID: 19236845
    25. overexpression of a dominant negative MEF2 mutant inhibited the enhancer activity of CNS13, decreased Hcn4 mRNA expression and also decreased the amplitude of I(h) current in myocytes isolated from the inflow tract of embryonic heart PMID: 19477969

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel HCN family
  • 組織特異性：
    Highly expressed in pyramidal and granule layer of the hippocampus, in thalamus anterior nucleus, in the supraoptic nucleus in hypothalamus, in cerebellum, and in trapezoid nuclei and superior olivary complex in the auditory system. Detected in a subset o
  • 數據庫鏈接：


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