在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Parathyroid hormone/parathyroid hormone-related peptide receptor (Pth1r), partial

Recombinant Rat Parathyroid hormone/parathyroid hormone-related peptide receptor (Pth1r), partial

  • 中文名稱：
    大鼠Pth1r重組蛋白
  • 貨號：
    CSB-YP018988RA1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Pth1r重組蛋白
  • 貨號：
    CSB-EP018988RA1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Pth1r重組蛋白
  • 貨號：
    CSB-EP018988RA1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Pth1r重組蛋白
  • 貨號：
    CSB-BP018988RA1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Pth1r重組蛋白
  • 貨號：
    CSB-MP018988RA1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pth1r; Pthr; Pthr1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
  • 基因功能參考文獻：
    1. Results show the expression of PTHrP and its receptor, PTHR1, in the majority of neurons and glial cells in the SCG of rats. Expression of PTHrP, but not PTHR1 in the cytoplasm of SCG neurons is influenced by ovarian activity. PMID: 25278090
    2. Data indicate that PTH1R and PTHrP were more predominantly expressed in smooth muscle than in urothelium. PMID: 23546599
    3. Vav2 specifically interacted with activated Galpha(q) but not with Galpha(s) subunits, competing with PTHR for coupling to Galpha(q). PMID: 22554804
    4. Nicotine induces PTHrP expression in endothelial cells but excessive concentrations of nicotine reduce PTHrP receptor expression thereby attenuating any protective effects of PTHrP against apoptosis. PMID: 22508055
    5. Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains PMID: 21832055
    6. This study demonstrates the dynamic expression of EBP50 in vessels following injury and the effects of EBP50 on PTH1R function in vascular smooth muscle cells. PMID: 20843475
    7. These findings suggest that FGFR3 down-regulates PTH/PTHrP receptor gene expression via the JAK/STAT signaling in chondrocytic cells. PMID: 20356821
    8. Downregulation of PTHrP and PTHrP-R gene expression during late lung morphogenesis may cause pulmonary hypoplasia in the nitrofen CDH model, disrupting alveolar maturation and surfactant production by interfering with mesenchymal-epithelial interactions. PMID: 19855984
    9. The impaired secretory capacity of the parathyroid glands in uremic rats is significantly enhanced by PTHrP. An autocrine/paracrine role in the parathyroid glands of the PTH/PTHrP receptor targeting peptides, PTHrP and PTH, is suggested. PMID: 12787396
    10. a high P diet with subsequent decrease in serum Ca concentration suppressed the PTH action in the kidney due to PTH/PTHrP receptor mRNA down-regulation PMID: 15618618
    11. An examination of parathyroid hormone-related peptide (PTHrP) receptor mRNA expression in 6-week-old parathyroidectomized rats. PMID: 15630249
    12. findings show the calpain small subunit binds to the N-terminal portion of PTH1R's intracellular tail; calpain hydrolyzes the C-tail of PTH1R in a Ca2+- and ligand-dependent manner; the absence and reduction of calpain activity affect PTH1R signaling PMID: 15691895
    13. PTH1R forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta, and nuclear PTH1R is associated with the nucleoplasm PMID: 16574786
    14. parathyroid hormone-related peptide, by interaction with the PTH1 receptor, can increase tubulointerstitial cell survival and seems to act as a proinflammatory and profibrogenic factor in the FA-damaged kidney PMID: 16672315
    15. data demonstrate that angiotensin II acts via the angiotensin II type 1 receptor to destabilize parathyroid hormone receptor 1(PTH1R) mRNA in the renal vessel in the spontaneously hypertensive rats model of genetic hypertension PMID: 16728497
    16. osteoblast PTH1R expression down-regulated at both the protein and mRNA levels in the steady state of chronic renal failure PMID: 17384996
    17. Nuclear Localization Signal at residues 471-488 of the mature rat PTH1R is functional and plays a role in targeting the PTH1R the nucleus PMID: 17627912
    18. Results conclude that PTH and PTHrP bind similarly to the G protein-coupled PTHR conformation, PTH has a greater capacity to bind to the G protein-uncoupled conformation. PMID: 17872377
    19. Studies proposed that, in ROS cells, the presence of NHERF1 induces PTH-dependent calcium signaling by a cAMP-mediated mechanism that involves local protein kinase A-dependent activation of calcium channels. PMID: 18202147
    20. PTH signaling to PLC is negatively regulated by PTH/PTHrP receptor phosphorylation and PKA. PMID: 18450967
    21. Defective transport of mutant PTH receptor(Pro132Leu) to the experimental cell surface indicate a molecular basis for Blomstrand's chondrodysplasia. PMID: 18480546
    22. The regulation of PTH1R expression by endogenous PTHrP and the associated effects on vascular smooth muscle cell proliferation, was investigated. PMID: 19574446

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數據庫鏈接：


主站蜘蛛池模板： 久久人搡人人玩人妻精品| 强开小婷嫩苞又嫩又紧视频| 美女裸体无遮挡免费视频网站| 久久婷婷五月综合色欧美| 亚洲色大成网站www永久麻豆 | 久久超碰精品一夜七次郎| 天天综合色天天综合色h| 无码国产精成人午夜视频| 2020无码天天喷水天天爽| 午夜精品久久久久久| 无遮挡国产高潮视频免费观看| 日产精品卡二卡三卡四卡乱码视频| 国产亚洲精品福利视频| 久久日本片精品aaaaa国产| 中文无码乱人伦中文视频在线| 无码欧精品亚洲日韩一区 | 人妻体内射精一区二区| 色综合av男人的天堂伊人| 四虎成人欧美精品在永久在线| 高清无码爆乳潮喷在线观看| 后入到高潮免费观看| 先锋影音最新色资源站| 黑色丝袜脚足国产在线看| 又爽又黄无遮挡高潮视频网站| 少妇真人直播免费视频| 大乳丰满人妻中文字幕日本 | 欧美亚洲色欲色一欲www| 国产精品福利一区二区久久| 国产精品综合色区在线观看| 欧美野外疯狂做受xxxx高潮| 香蕉噜噜噜噜私人影院| 久久精品中文字幕第一页| 国产精品一区二区无线| 五月婷婷俺也去开心| 国产精品久久久久秋霞鲁丝| 免费不卡无码av在线观看| 日本亚洲欧洲无免费码在线| 天堂资源中文网| 非洲黑人性xxxx精品| 亚洲精品久久久久一区二区| 一本大道无码日韩精品影视丶|