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  4. Recombinant Rat PDZ and LIM domain protein 4 (Pdlim4)

Recombinant Rat PDZ and LIM domain protein 4 (Pdlim4)

  • 中文名稱：
    大鼠Pdlim4重組蛋白
  • 貨號：
    CSB-YP017735RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Pdlim4重組蛋白
  • 貨號：
    CSB-EP017735RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Pdlim4重組蛋白
  • 貨號：
    CSB-EP017735RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Pdlim4重組蛋白
  • 貨號：
    CSB-BP017735RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Pdlim4重組蛋白
  • 貨號：
    CSB-MP017735RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Pdlim4
  • Uniprot No.：
  • 別名：
    Pdlim4; Ril; PDZ and LIM domain protein 4; H-REV18; LIM protein RIL; RIT-18; Reversion-induced LIM protein
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-330
  • 氨基酸序列
    MTHAVTLRGP SPWGFRLVGG RDFSAPLTIS RVHAGSKAAL AALCPGDSIQ AINGESTELM THLEAQNRIK GCHDHLTLSV SRPENKNWPS SPNDKAQAHR IHIDPEAQDG SPATSRRSSI SGISLEDNRS GLGSPYGQPP RLPVPHNGSS NEVTLPSQMS ALHVSPPPSA DTPRILPRNR DCRVDLGSEV YRMLREPAEP AASEPKQSGS FRYLQGMLEA GEGGDRPGSG GSRNLKPAAS KLGAPLSGLQ GLPECTRCGH GIVGTIVKAR DKLYHPECFM CSDCGLNLKQ RGYFFLDERL YCENHAKARV KPPEGYDVVA VYPNAKVELV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons.
  • 基因功能參考文獻：
    1. The RIL has a redundant role in the formation of stress fibers, but have different effects on stress fiber dynamics in F2408 cells. PMID: 22659164
    2. Ril modulates actin stress fiber turnover and enhances the association with actinin and actins. PMID: 14729062
    3. RIL directs the transport of GluR-A-containing AMPA receptors to and/or within dendritic spines, in an alpha-actinin/actin-dependent manner. PMID: 15456832
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, dendritic spine. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell junction, synapse, synaptosome.
  • 組織特異性：
    Detected in several tissues, most prominent in brain and heart of adults. Expressed in embryonic fibroblasts.
  • 數據庫鏈接：


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