在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Mothers against decapentaplegic homolog 4 (Smad4)

  • 中文名稱:
    大鼠Smad4重組蛋白
  • 貨號:
    CSB-YP021789RA
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Smad4重組蛋白
  • 貨號:
    CSB-EP021789RA
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Smad4重組蛋白
  • 貨號:
    CSB-EP021789RA-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Smad4重組蛋白
  • 貨號:
    CSB-BP021789RA
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Smad4重組蛋白
  • 貨號:
    CSB-MP021789RA
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Smad4; Madh4; Mothers against decapentaplegic homolog 4; MAD homolog 4; Mothers against DPP homolog 4; SMAD family member 4; SMAD 4; Smad4
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full length protein
  • 表達(dá)區(qū)域:
    1-552
  • 氨基酸序列
    MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPPSMLVKD EYVHDFEGQP SLPTEGHSIQ TIQHPPSNRA STETYSAPAL LAPSESNATS TTNFPNIPVA STSQPASILA GSHSEGLLQI ASGPQPGQQQ NGFTAQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP AISLSAAAGI GVDDLRRLCI LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL HTMPIADPQP LD
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8.
  • 基因功能參考文獻(xiàn):
    1. This study identified a novel role of Smad4 SUMOylation and TPM2 in learning and memory formation. These results suggest that patients with skeletal myopathies who carry the TPM2E122K mutation may also have deficits in learning and memory functions. PMID: 29183317
    2. The results demonstrate that miR124 upregulation inhibits the growth of C6 glioma cells by targeting Smad4 directly. PMID: 28791348
    3. Smad4-dependent TGF-beta signaling in smooth muscle cells protects against aortic aneurysm formation and dissection. PMID: 26699655
    4. These results suggest that high glucose may activate TGF- beta/Smad signaling through sumoylation of Samd4 by SUMO2/3 in mesangial cells. PMID: 24971350
    5. miR-146a is overexpressed in an experimentally induced osteoarthritis model, accompanied by upregulation of VEGF and downregulation of Smad4 in vivo PMID: 22507670
    6. Bioinformatics analyses predict that Smad4 is the potential target of miR-146a. PMID: 22735812
    7. MicroRNA mimics, inhibitors and siRNA studies indicate the role of SMAD4 as inhibitory for glucose transport activities in normal physiological condition. PMID: 22506032
    8. Schisandrin B can reduce pulmonary fibrosis induced by SiO2 through inhibition of mRNA expression of TGF-beta1 and Smad4 in the lung tissue. PMID: 21941776
    9. TGF-beta1 and Smad4 may be involved in the pathogenesis of chronic nonbacterial prostatitis. PMID: 20608350
    10. The results showed that the protein of Smad4 was present in rats from 3 days of age to adulthood, and the immunoreactivity for Smad4 was exclusively localized to the cytoplasm of Leydig cells with negative nuclei in the interstitial tissue. PMID: 15344310
    11. Expression of BMP receptors Ib and II, and Smad 4 was downregulated in lungs but not kidneys of MCT-treated rats. PMID: 17347486
    12. Data show that SMAD4 triggers the transition from hypertrophy to apoptosis in ventricular cardiomyocytes, and suggest that it may trigger apoptosis induction and therefore contributes to negative remodeling and heart failure progression. PMID: 19415695

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Dwarfin/SMAD family
  • 數(shù)據(jù)庫鏈接:

    KEGG: rno:50554

    UniGene: Rn.9774



主站蜘蛛池模板: 国产精品美女乱子伦高潮| 无套内射在线观看theporn| 亚洲欲色欲色xxxxx在线| 国偷自产视频一区二区久| 欧美成人午夜精品久久久| 精品国产av色一区二区深夜久久 | 亚洲国产中文曰韩丝袜| 精品国产日韩亚洲一区| 欧美拍拍视频免费大全| 中文字幕av一区二区三区人妻少妇| 欧美 日韩 亚洲 在线| 日日橹狠狠爱欧美视频| 无码人妻一区二区三区免费n鬼逝| 日本一区二区三区免费播放| 99精品电影一区二区免费看| 国产免费无码一区二区视频| 亚洲高清成人aⅴ片| 亚洲国产精品无码久久一区二区| 午夜伦费影视在线观看| 日本公妇乱偷中文字幕| 中文字幕人成无码人妻| 天天摸日日摸爽爽狠狠| 丰满少妇被粗大猛烈进人高清| 国产精品门事件av| 亚洲多毛妓女毛茸茸的| 国产日韩综合一区二区性色av| 天天天天做夜夜夜夜做无码| 免费无码又爽又刺激成人 | 亚洲熟妇丰满多毛xxxx| 亚洲国产无线乱码在线观看| 久久免费精品国产72精品| 无码熟妇人妻av在线影片免费| 人妻精品人妻无码一区二区三区 | 国产偷亚洲偷欧美偷精品| 国产精品香蕉在线观看| 男人的天堂av社区在线| 久久久久人妻一区精品果冻| 欧美俄罗斯乱妇| 曰本无码不卡高清av一二| 中文字幕 乱码 中文乱码视频| 亚洲成a人v欧美综合天堂|