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Recombinant Rat Microtubule-associated protein 2 (Map2), partial

  • 中文名稱:
    大鼠Map2重組蛋白
  • 貨號:
    CSB-YP013408RA
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Map2重組蛋白
  • 貨號:
    CSB-EP013408RA
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Map2重組蛋白
  • 貨號:
    CSB-EP013408RA-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Map2重組蛋白
  • 貨號:
    CSB-BP013408RA
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Map2重組蛋白
  • 貨號:
    CSB-MP013408RA
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Map2; Mtap2; Microtubule-associated protein 2; MAP-2
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
  • 基因功能參考文獻:
    1. selective axonal cargo trafficking requires the MAP2-defined pre-axonal filtering zone and the ability of cargos to switch between distinct kinesin motor activities PMID: 28426968
    2. dephosphorylation of MAP2D at Thr256 and Thr259, phosphorylation of vimentin at Ser38 and Ser72, and the resulting enhanced binding of MAP2D to vimentin might contribute to the progesterone synthetic response required for ovulation. PMID: 27335427
    3. This study demonstrated that motor skills training after ICH significantly improved motor and sensory functions as well as promoting MAP2 mRNA expression. PMID: 27265094
    4. Increased GluN2A, synaptophysin, BDNF, but not MAP2, observed after neonatal prebiotic feeding may suggest alteration in neurotransmission rather than synaptic architecture PMID: 26682524
    5. MAP2c/MAP2 could be one of the regulators maintaining tau homeostasis in the cell PMID: 26071842
    6. At the subcellular level CSI also showed significant impact on NFs and MAP-2 expression PMID: 25592752
    7. The obtained data provides the first atomic resolution insight into the conformational state of MAP2c. PMID: 23877929
    8. in neurons MARTA2 appears to represent a key trans-acting factor involved in dendritic targeting of MAP2 mRNAs. PMID: 23121659
    9. The effects of nerve growth factor (NGF) or neurotrophin-3 (NT-3) on the expression of mRNAs for PPT, CGRP, NF-200, and MAP-2 was analyzed by real time-PCR assay. PMID: 22763971
    10. The brightness-area-product of MAP2 changes significantly across estrous cycle oscillations; it is twice as high in proestrus than in metestrus and estrus rats, and 1.5 times higher in proestrus than in diestrus rats. PMID: 21948316
    11. The expression of MAP-2 is strongly associated with the integrity of hippocampal neurons in young rats. Low-dose X-rays may promote the proliferation of hippocampal microtubule in hippocampus and further promote the expression of MAP-2. PMID: 22490839
    12. The MAP2 content only increased in the preoptic area at 24 h, and in the frontal cortex after 24 and 72 h of REM sleep deprivation. PMID: 22456537
    13. Serum levels of MAP2 remarkably increase as early as 0.5 hr following ischemia, much sooner than the observation of minimal tissue injury 3 hr following occlusion. PMID: 21948028
    14. morphological changes resulting from cortical compression may be related to reductions in MAP2-immunoreactive materials PMID: 21401443
    15. But MAP-2 neurons significantly decreased on just the 3rd day after chronic constriction injury. PMID: 21933624
    16. Progesterone decreased MAP2 content after a short-term treatment, while it increased that of MAP2 and TAU in this brain region after a long-term treatment. PMID: 21683086
    17. A transient increase in microtubule-associated protein (MAP)2 follows compressive injury of the cerebral cortex. PMID: 20568963
    18. The expression of MAP-2 mRNA gradually increased in the focus of the cerebral contusion from 12h to 14d after contusion. PMID: 20967947
    19. hyperbaric oxygenation treatment for cerebral infarction, can increase the expression of Map-2 and decrease the expression of GFAP. PMID: 19141977
    20. These results suggest that the involvement of repeated restraint stress alter the content and neuronal distribution of MAP2. PMID: 20513368
    21. Nitric oxide affects the phosphorylation state of microtubule-associated protein 2 in brain. PMID: 11829530
    22. In the developing telencephalon, high- and low-molecular-weight variants of MAP2 are differentially localized in a manner dependent on the process of maturation of the embryonic cortical neurons. PMID: 12115669
    23. In MAP2-deficient neurons, the induction of phosphorylated CREB after forskolin stimulation was much lower. MAP2 is an anchoring protein of protein kinase A in dendrites, whose loss reduces dendritic and total PKA and reduced CREB. PMID: 12163474
    24. Phosphorylation by protein kinase A within the proline-rich region of MAP2c at threonine-220 affects microtubule binding and stability PMID: 12369833
    25. MAP2 protein content is significantly increased in the hippocampus following administration of both estradiol and progesterone. PMID: 12372566
    26. Results support the existence of regions of nascent structure in the N-terminal region of microtubule-associated protein 2 (MAP2), which are believed to contribute to its regulatory function. PMID: 12535652
    27. After brain ischemia, MAP2 immunoreactivity was significantly reduced in the cerebral cortex and hippocampus. PMID: 12757367
    28. The proteolysis of MAP2 is limited by endogenous calpain activity, likely via the spatial access of calpain to MAP2. PMID: 12834896
    29. The level of Map2 and the rate of its phosphorylation were increased in neurons of this inbred strain (in comparison to Wistar rats). Daily kindling further decreased the length of microtubule fragments. PMID: 14989172
    30. activity regulated cytoskeletal-associated proteininteracted with newly polymerized microtubules and microtubule-associated protein 2, leading to blocking of the epitope of microtubule-associated protein 2 PMID: 15048929
    31. GAP-43 and MAP-2 in the brain have roles in oxidative stress and aging PMID: 15246990
    32. We suggest that changes in MAP2 are involved in the structural changes that occur in the hippocampus of the rat during the estrous cycle, and that these variations are related to changes in estradiol and progesterone levels. PMID: 15307151
    33. Cognitive impairment and the expression patterns of MAP-2, GAP-43, and synaptophysin were examined in rats with permanent occlusion of bilateral common carotid arteries. PMID: 15964096
    34. JNK1 phosphorylation of MAP2 plays an important role in defining dendritic architecture in the brain. PMID: 16000625
    35. Neonatal treatment with pregnenolone and DHEA increased the expression of MAP-2 in the rat hippocampus and nucleus accumbens but not in the prefrontal cortex, striatum or amygdala in adulthood. PMID: 16002213
    36. Stimulatory effects of pregnenolone and 3beta-methoxypregnenolone on neurite extension show that MAP2 is neurosteroid specific receptor. PMID: 16537405
    37. MAP2 is involved in ERK3 mediated insulin secretion PMID: 16597486
    38. Within the somatosensory cortex, MK801 triggered robust, caspase-3-dependent apoptotic injury, reduced expression of cytoskeletal proteins MAP2 and tau, and increased synapse associated protein SNAP25. PMID: 16708014
    39. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites PMID: 16901895
    40. Expression of MAP2 does not seem to indicate difficulty of task or duration of training time. PMID: 17141532
    41. The strictly developmentally regulated MAP2 isoform expression suggests different functional roles for these proteins during the postnatal development in the rat hippocampus. PMID: 17229541
    42. Prolactin increased the association between SNARE proteins and kinesin/MAP-2 while the association of munc-18/syntaxin 1A was decreased. PMID: 17573185
    43. In PC12 cells, epinephrine induces phosphorylation of MAP-2c at ser136 through a alpha 2-adrenoceptor mediated, ERK/PKC-dependent signaling pathway, which may contribute to the stabilization of neurites. PMID: 18290605
    44. Gap-43 co-localizes and potentially interacts with microtubule-associated protein MAP-2 in adult and fetal rat brain, as well as in primary neuronal cultures. PMID: 18455509
    45. Progesterone maintained in part neuronal ultrastructure, attenuated chromatolysis, and preclude the loss of MAP2, suggesting a protective effect during the early phases of spinal cord injury. PMID: 18584320
    46. data reveal occurrence of interactions between microtubule polymers involving MAP2 and modulated by cAMP; findings imply role for the complex of cAMP-dependent protein kinase A with the projection domain of MAP2 in microtubule-microtubule interactions PMID: 19009287
    47. Protein kinase A was concentrated in dendritic shafts; this distribution was imposed by the microtubule-binding protein MAP2, indicating that MAP2 is the dominant A-kinase anchoring protein in neurons. PMID: 19447092

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  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell projection, dendrite.
  • 數據庫鏈接:


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