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  4. Recombinant Rat Lanosterol synthase (Lss)

Recombinant Rat Lanosterol synthase (Lss)

  • 中文名稱：
    大鼠Lss重組蛋白
  • 貨號：
    CSB-YP013216RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Lss重組蛋白
  • 貨號：
    CSB-EP013216RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Lss重組蛋白
  • 貨號：
    CSB-EP013216RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Lss重組蛋白
  • 貨號：
    CSB-BP013216RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Lss重組蛋白
  • 貨號：
    CSB-MP013216RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Lss
  • Uniprot No.：
  • 別名：
    Lss; OscLanosterol synthase; EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-733
  • 氨基酸序列
    TEGTCLRRR GGPYKTEPAT DLTRWRLHNE LGRQRWTYYQ AEEDPGREQT GLEAHSLGLD TTSYFKNLPK AQTAHEGALN GVTFYAKLQA EDGHWAGDYG GPLFLLPGLL ITCHIAHIPL PAGYREEMVR YLRSVQLPDG GWGLHIEDKS TVFGTALSYV SLRILGIGPD DPDLVRARNI LHKKGGAVAI PSWGKFWLAV LNVYSWEGIN TLFPEMWLLP EWFPAHPSTL WCHCRQVYLP MSYCYATRLS ASEDPLVQSL RQELYVEDYA SIDWPAQKNN VCPDDMYTPH SWLLHVVYGL LNLYERFHST SLRKWAIQLL YEHVAADDRF TKCISIGPIS KTVNMLIRWS VDGPSSPAFQ EHVSRIKDYL WLGLDGMKMQ GTNGSQTWDT SFAVQALLEA GAHRRPEFLP CLQKAHEFLR LSQVPDNNPD YQKYYRHMHK GGFPFSTLDC GWIVADCTAE ALKAVLLLQE RCPSITEHVP RERLYDAVAV LLSMRNSDGG FATYETKRGG YLLELLNPSE VFGDIMIDYT YVECTSAVMQ ALRHFREYFP DHRATESRET LNQGLDFCRK KQRADGSWEG SWGVCFTYGT WFGLEAFACM GHIYQNRTAC AEVAQACHFL LSRQMADGGW GEDFESCEQR RYVQSAGSQV HSTCWALLGL MAVRHPDISA QERGIRCLLG KQLPNGDWPQ ENISGVFNKS CAISYTNYRN IFPIWALGRF SSLYPDNTLA GHI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
  • 基因功能參考文獻：
    1. Data suggest that cholesterol insufficiency due to mutation in lanosterol synthase may underlie the deficient proliferation of lens epithelial cells, which may eventually lead to cataractogenesis in Shumiya cataract rats. PMID: 16440058
    2. These observations suggest an involvement of PCSK9 in hepatic LDL receptor protein degradation and perhaps, in increasing the rate of LDL receptor cycling resulting in lower serum cholesterol levels in response to cholesterol biosynthesis inhibitors. PMID: 18054775
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    Terpene cyclase/mutase family
  • 數據庫鏈接：

    KEGG: rno:81681

    UniGene: Rn.10211



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