在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Histone deacetylase 3 (Hdac3)

  • 中文名稱:
    大鼠Hdac3重組蛋白
  • 貨號:
    CSB-YP010239RA
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Hdac3重組蛋白
  • 貨號:
    CSB-EP010239RA
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Hdac3重組蛋白
  • 貨號:
    CSB-EP010239RA-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Hdac3重組蛋白
  • 貨號:
    CSB-BP010239RA
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Hdac3重組蛋白
  • 貨號:
    CSB-MP010239RA
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Hdac3; Histone deacetylase 3; HD3; EC 3.5.1.98
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-428
  • 氨基酸序列
    MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI SQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN DKESDVEI
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Contributes, together with XBP1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress. Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner. During the activation phase, promotes the accumulation of ubiquitinated ARNTL/BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and ARNTL/BMAL1. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response.
  • 基因功能參考文獻:
    1. Co-regulation of H3K9ac by HDAC1 and HDAC3 is important development of the pathophysiology of a schizophrenia-like phenotype. PMID: 28300292
    2. Findings provide evidence that amyloid-beta oligomer-induced synaptic plasticity impairment can be prevented by inhibition of HDAC3 enzyme both at the single neuron as well as in a population of neurons, thus identifying HDAC3 as a potential target for ameliorating Alzheimer's disease related plasticity impairments PMID: 26890755
    3. c-Fos can protect against HDAC3 neurotoxicity. PMID: 25592718
    4. There was no difference in striatal HDAC3 expression between maternally deprived rats and controls. PMID: 23980619
    5. Data shows that HDAC3 is a substrate of GSK3beta and that HDAC3 represents a downstream effector of GSK3beta neurotoxicity. PMID: 21289184
    6. recruitment of HDAC3 is a process by which Myc represses gene activity PMID: 18483244

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytosol.
  • 蛋白家族:
    Histone deacetylase family, HD type 1 subfamily
  • 數據庫鏈接:

    KEGG: rno:84578

    UniGene: Rn.17284



主站蜘蛛池模板: 人妻av中文字幕久久| 一本一道vs无码中文字幕| 天堂а√在线最新版中文| 香蕉eeww99国产精选免费| 无码超乳爆乳中文字幕| 亚洲成av人综合在线观看| 亚洲综合小说另类图片五月天| 午夜成人亚洲理论片在线观看| 欧洲女人牲交视频免费| 么公的好大好硬好深好爽视频| 国产丝袜无码一区二区视频| 女人夜夜春高潮爽a∨片| 美女视频黄频大全免费| b站永久免费看片大全| 永久免费男同av无码入口| 亚洲自偷自拍另类小说| 大肉大捧一进一出好爽视频mba| 国产肉体ⅹxxx137大胆| 特黄做受又硬又粗又大视频小说| 中文字幕大看蕉在线观看| 丰满人妻翻云覆雨呻吟视频| 免费夜色污私人影院在线观看| 久99视频精品免费观看福利| 国产成人久久综合第一区| 国产精品久久一区二区三区| 麻豆 美女 丝袜 人妻 中文| 国产欧美在线一区二区三| 国产69精品久久久久乱码韩国| 亚洲精品无码一区二区| 久久精品国产福利一区二区 | 欧美精品18videos性欧美| 亚洲精品nv久久久久久久久久 | 无码av大香线蕉伊人久久| 成人亚洲a片v一区二区三区蜜臀 | 日韩亚洲欧美精品综合| 99精品偷自拍| 亚洲国产欧美一区点击进入| 日韩国产亚洲一区二区三区| 夜夜春夜夜爽| 西西人体大胆午夜啪啪| 国产午夜福利不卡在线观看|