在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Hexokinase-1 (Hk1), partial

Recombinant Rat Hexokinase-1 (Hk1), partial

  • 中文名稱：
    大鼠Hk1重組蛋白
  • 貨號：
    CSB-YP010468RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Hk1重組蛋白
  • 貨號：
    CSB-EP010468RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Hk1重組蛋白
  • 貨號：
    CSB-EP010468RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Hk1重組蛋白
  • 貨號：
    CSB-BP010468RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Hk1重組蛋白
  • 貨號：
    CSB-MP010468RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Hk1Hexokinase-1; EC 2.7.1.1; Brain form hexokinase; Hexokinase type I; HK I; Hexokinase-A
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome.
  • 基因功能參考文獻：
    1. results suggest that phenylpyruvic acid is the cause of the reduction of glucose consumption by decreasing hexokinase activity. Therefore, production of ATP declines in brain cells. PMID: 28275929
    2. There was an increase in hexokinase1 expression in right ventricle from pulmonary hypertension rats. PMID: 25287584
    3. Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls. PMID: 22420779
    4. The results show that Hk1 and GLUT3 may play a role in the pathophysiology of ketamine-induced behavioral abnormalities. PMID: 22605548
    5. The activities of HK in all subcellular fractions are enhanced in response to myocardial infarction PMID: 20060179
    6. Abeta-induced cellular redistribution and inactivation of neuronal HKI play important roles in oxidative stress and neurodegeneration in Alzheimer's disease PMID: 21179577
    7. HKI remains strongly bound to mitochondria, whereas HKII translocates between mitochondria and the cytosol in response to glucose, G-6-P and Akt, but not ATP. PMID: 21408025
    8. the Hexokinase-mitochondria interaction mediated by Akt has a role in inhibiting apoptosis but does not require Bax and Bak PMID: 15574336
    9. results imply that the high hexokinase-binding capability of porin-enriched mitochondria was due to a quantitative difference in binding sites PMID: 15756812
    10. Findings suggest the presence of hexokinase I in detergent-resistant membrane domains of spermatogenic cells, and support a role for caveolae in relation to glucose uptake and glucose phosphorylation. PMID: 16419038
    11. These events are isoform specific, suggesting that HK I and HK II are independently regulated and implying that they perform different roles in cardiac glucose regulation. PMID: 16951044
    12. Cmplex effects of diabetes on hexokinase I expression in the DRG may be due to glucose-driven up-regulation of expression or the result of impaired axonal transport and perikaryal accumulation in the large neuron sub-population. PMID: 17803972
    13. Between these two strategies to activate glycogen deposition in the absence of GK, embryonic livers choose to express massive levels of HKI and HKII. PMID: 18165236
    14. The results support a key role for hexokinase activity and/or localization to the mitochondria in the regulation of neurite outgrowth in cultured adult sensory neurons. PMID: 18308470
    15. Ischemic preconditioning is associated with 1) a biphasic response of increased mitochondrial HK activity before and after ischemia, 2) decreased cytosolic HK activity during ischemia, and 3) cellular redistribution of HKII but not HKI. PMID: 19228992

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol.
  • 蛋白家族：
    Hexokinase family
  • 組織特異性：
    Expressed in flagella of epididymal sperm.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 亚洲精品国产成人一区二区| 国产成人欧美综合在线影院| 国产精品久久久久不卡绿巨人| 青青青草国产线观| 麻花传媒剧国产mv高清播放| 中文资源在线天堂库8| 超薄丝袜足j好爽在线| 在线视频免费观看爽爽爽| 亚洲伊人久久大香线蕉综合图片 | 国产成人无码精品亚洲| 国产av无码专区亚洲a∨毛片| 精品久久久久久无码人妻蜜桃| 国产成久久免费精品av片| 麻豆国产av超爽剧情系列| 伊人色综合一区二区三区| 一本久道久久综合狠狠躁av| 中文字幕亚洲男人的天堂网络| 久久亚洲国产成人精品性色| 国内老熟妇对白hdxxxx| 国产福利在线视频蜜芽tv| 亚洲五月综合缴情在线观看| 亚洲成av人片在线观看天堂无码 | 亚洲欧美日本国产专区一区| 韩国的无码av看免费大片在线| 精品人妻无码区二区三区| 日本最新免费二区三区| 看国产黄大片在线观看| 男女啪啦啦超猛烈动态图| 在线播放免费人成视频在线观看| 精品人妻少妇嫩草av无码专区| 亚洲精品无码国产| 国产精品无码专区第一页| 日韩va中文字幕无码电影| 久久精品66免费99精品| 最新精品国偷自产在线老年人| 亚洲国产精华液网站w| 亚洲精品久久久www| 国产萌白酱喷水视频在线播放 | 国产亚洲视频在线观看网址| 潮喷失禁大喷水aⅴ无码| 99久久久无码国产精品免费|